Mechanisms involved in the antidepressant-like action of orally administered 5-((4-methoxyphenyl)thio)benzo[c][1,2,5]thiadiazole (MTDZ) in male and female mice.
Antidepressant
Behavior
Depression
Enzyme
Thiadiazoles
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
15 Jul 2024
15 Jul 2024
Historique:
received:
27
11
2023
accepted:
02
07
2024
medline:
15
7
2024
pubmed:
15
7
2024
entrez:
15
7
2024
Statut:
aheadofprint
Résumé
The compound 5-((4-methoxyphenyl)thio)benzo[c][1,2,5]thiadiazole (MTDZ) has recently been shown to inhibit in vitro acetylcholinesterase activity, reduce cognitive damage, and improve neuropsychic behavior in mice, making it a promising molecule to treat depression. This study investigated the antidepressant-like action of MTDZ in mice and its potential mechanisms of action. Molecular docking assays were performed and suggested a potential inhibition of monoamine oxidase A (MAO-A) by MTDZ. The toxicity study revealed that MTDZ displayed no signs of toxicity, changes in oxidative parameters, or alterations to biochemistry markers, even at a high dose of 300 mg/kg. In behavioral tests, MTDZ administration reduced immobility behavior during the forced swim test (FST) without adjusting the climbing parameter, suggesting it has an antidepressant effect. The antidepressant-like action of MTDZ was negated with the administration of 5-HT1A, 5-HT1A/1B, and 5-HT3 receptor antagonists, implying the involvement of serotonergic pathways. Moreover, the antidepressant-like action of MTDZ was linked to the NO system, as L-arginine pretreatment inhibited its activity. The ex vivo assays indicated that MTDZ normalized ATPase activity, potentially linking this behavior to its antidepressant-like action. MTDZ treatment restricted MAO-A activity in the cerebral cortices and hippocampi of mice, proposing a selective inhibition of MAO-A associated with the antidepressant-like effect of the compound. These findings suggest that MTDZ may serve as a promising antidepressant agent due to its selective inhibition of MAO-A and the involvement of serotonergic and NO pathways.
Identifiants
pubmed: 39008059
doi: 10.1007/s00213-024-06647-0
pii: 10.1007/s00213-024-06647-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : PqG 19/2551-0001745-6
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 160674/2020-4
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 001
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Albert PR (2015) Why is depression more prevalent in women? J Psychiatry Neurosci 40(4):219–221. https://doi.org/10.1503/jpn.150205
doi: 10.1503/jpn.150205
pubmed: 26107348
pmcid: 4478054
Alvarez J-C, Sanceaume M, Advenier C, Spreux-Varoquaux O (1999) Differential changes in brain and platelet 5-HT concentrations after steady-state achievement and repeated administration of antidepressant drugs in mice. Eur Neuropsychopharmacol 10(1):31–36. https://doi.org/10.1016/S0924-977X(99)00048-6
doi: 10.1016/S0924-977X(99)00048-6
pubmed: 10647094
Antoniuk S, Bijata M, Ponimaskin E, Wlodarczyk J (2019) Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability. Neurosci Biobehavioral Reviews 99:101–116. https://doi.org/10.1016/j.neubiorev.2018.12.002
doi: 10.1016/j.neubiorev.2018.12.002
Ben-Azu B, Aderibigbe AO, Ajayi AM, Omogbiya IA, Uruaka CI, Umukoro S, Iwalewa EO (2021) Evaluation of the role of monoaminergic and nonmonoaminergic systems in the psychotropic effects of morin in mice: an interaction study with receptor blockers. Nutrire 46(1):8. https://doi.org/10.1186/s41110-021-00137-5
doi: 10.1186/s41110-021-00137-5
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1–2):248–254. https://doi.org/10.1016/0003-2697(76)90527-3
doi: 10.1016/0003-2697(76)90527-3
pubmed: 942051
Candee R, Wilkenson R, Schreiber M, DeCenzo M (2023) The roles of neuroinflammation and glutamatergic excitotoxicity in treatment-resistant depression. JAAPA 36(4):12–17. https://doi.org/10.1097/01.JAA.0000921252.57819.4b
doi: 10.1097/01.JAA.0000921252.57819.4b
pubmed: 36913608
Casaril AM, Domingues M, De Andrade Lourenço D, Birmann PT, Padilha N, Vieira B, Begnini K, Seixas FK, Collares T, Lenardão EJ, Savegnago L (2019) Depression- and anxiogenic-like behaviors induced by lipopolysaccharide in mice are reversed by a selenium-containing indolyl compound: behavioral, neurochemical and computational insights involving the serotonergic system. J Psychiatr Res 115:1–12. https://doi.org/10.1016/j.jpsychires.2019.05.006
doi: 10.1016/j.jpsychires.2019.05.006
pubmed: 31082651
da Costa Rodrigues K, Leivas de Oliveira R, da Silva Chaves J, Esteves da Rocha VM, Fuzinato dos Santos B, Fronza MG, Luís de Campos Domingues N, Savegnago L, Wilhelm EA, Luchese C (2022) A new arylsulfanyl-benzo-2,1,3-thiadiazoles derivative produces an anti-amnesic effect in mice by modulating acetylcholinesterase activity. Chemico-Biol Interact 351:109736. https://doi.org/10.1016/j.cbi.2021.109736
doi: 10.1016/j.cbi.2021.109736
da Motta KP, Santos BF, Domingues NLDC, Luchese C, Wilhelm EA (2022) Target enzymes in oxaliplatin-induced peripheral neuropathy in Swiss mice: a new acetylcholinesterase inhibitor as therapeutic strategy. Chemico-Biol Interact 352:109772. https://doi.org/10.1016/j.cbi.2021.109772
doi: 10.1016/j.cbi.2021.109772
De Colibus L, Li M, Binda C, Lustig A, Edmondson D. E., Mattevi A (2005) Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. Proc Natl Acad Sci 102(36):12684–12689. https://doi.org/10.1073/pnas.0505975102
doi: 10.1073/pnas.0505975102
pubmed: 16129825
pmcid: 1200291
De Oliveira RL, Voss GT, Paltian JJ, Pinz MP, Torres MLCP, Moreira MP, Dilelio MC, Silveira CC, Wilhelm EA, Luchese C (2019) Contribution of serotonergic and nitrergic pathways, as well as monoamine oxidase-a and Na+, K+-ATPase enzymes in antidepressant-like action of ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide (BMMS). Metab Brain Dis 34(5):1313–1324. https://doi.org/10.1007/s11011-019-00436-x
doi: 10.1007/s11011-019-00436-x
pubmed: 31177357
Edmondson DE, Binda C, Wang J, Upadhyay AK, Mattevi A (2009) Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine Oxidases. Biochemistry 48(20):4220–4230. https://doi.org/10.1021/bi900413g
doi: 10.1021/bi900413g
pubmed: 19371079
El-Mallakh RS (1983) The Na,K-ATPase hypothesis for manic-depression. I. General considerations. Med Hypotheses 12(3):253–268. https://doi.org/10.1016/0306-9877(83)90042-7
doi: 10.1016/0306-9877(83)90042-7
pubmed: 6321918
Eltokhi A, Kurpiers B, Pitzer C (2021) Baseline Depression-Like behaviors in Wild-Type adolescent mice are strain and age but not sex dependent. Front Behav Neurosci 15:759574. https://doi.org/10.3389/fnbeh.2021.759574
doi: 10.3389/fnbeh.2021.759574
pubmed: 34690714
pmcid: 8529326
Fabbri C, Serretti A (2020) Clinical application of antidepressant pharmacogenetics: considerations for the design of future studies. Neurosci Lett 726:133651. https://doi.org/10.1016/j.neulet.2018.06.020
doi: 10.1016/j.neulet.2018.06.020
pubmed: 29906483
Faul F, Erdfelder E, Lang A-G, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39(2):175–191. https://doi.org/10.3758/BF03193146
doi: 10.3758/BF03193146
pubmed: 17695343
Fernandes SS, Koth AP, Parfitt GM, Cordeiro MF, Peixoto CS, Soubhia A, Moreira FP, Wiener CD, Oses JP, Kaszubowski E, Barros DM (2018) Enhanced cholinergic-tone during the stress induce a depressive-like state in mice. Behav Brain Res 347:17–25. https://doi.org/10.1016/j.bbr.2018.02.044
doi: 10.1016/j.bbr.2018.02.044
pubmed: 29501509
Finberg JPM, Rabey JM (2016) Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology. Front Pharmacol 7. https://doi.org/10.3389/fphar.2016.00340
Fiske CH, Subbarow Y (1925) THE COLORIMETRIC DETERMINATION OF PHOSPHORUS. J Biol Chem 66(2):375–400. https://doi.org/10.1016/S0021-9258(18)84756-1
doi: 10.1016/S0021-9258(18)84756-1
Friedrich T, Tavraz NN, Junghans C (2016) ATP1A2 mutations in migraine: seeing through the facets of an Ion Pump onto the Neurobiology of Disease. Front Physiol 7. https://doi.org/10.3389/fphys.2016.00239
Geha RM, Chen K, Wouters J, Ooms F, Shih JC (2002) Analysis of conserved active site residues in Monoamine Oxidase A and B and their three-dimensional molecular modeling. J Biol Chem 277(19):17209–17216. https://doi.org/10.1074/jbc.M110920200
doi: 10.1074/jbc.M110920200
pubmed: 11861643
Ghasemi M, Claunch J, Niu K (2019) Pathologic role of nitrergic neurotransmission in mood disorders. Prog Neurobiol 173:54–87. https://doi.org/10.1016/j.pneurobio.2018.06.002
doi: 10.1016/j.pneurobio.2018.06.002
pubmed: 29890213
Gonçalves AE, Bürger C, Amoah SKS, Tolardo R, Biavatti MW, De Souza MM (2012) The antidepressant-like effect of Hedyosmum brasiliense and its sesquiterpene lactone, podoandin in mice: evidence for the involvement of adrenergic, dopaminergic and serotonergic systems. Eur J Pharmacol 674(2–3):307–314. https://doi.org/10.1016/j.ejphar.2011.11.009
doi: 10.1016/j.ejphar.2011.11.009
pubmed: 22115892
Goodwill HL, Manzano-Nieves G, Gallo M, Lee H-I, Oyerinde E, Serre T, Bath KG (2019) Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model. Neuropsychopharmacology 44(4):711–720. https://doi.org/10.1038/s41386-018-0195-5
doi: 10.1038/s41386-018-0195-5
pubmed: 30188513
Guze SB (1995) Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV). American Journal of Psychiatry, 152(8), 1228–1228. https://doi.org/10.1176/ajp.152.8.1228
Hanwell MD, Curtis DE, Lonie DC, Vandermeersch T, Zurek E, Hutchison GR (2012) Avogadro: an advanced semantic chemical editor, visualization, and analysis platform. J Cheminform 4(1):17. https://doi.org/10.1186/1758-2946-4-17
doi: 10.1186/1758-2946-4-17
pubmed: 22889332
pmcid: 3542060
Hesketh JE, Glen AIM, Reading HW (1977) Memberane ATPase activities in depressive illness. J Neurochem 28(6):1401–1402. https://doi.org/10.1111/j.1471-4159.1977.tb12341.x
doi: 10.1111/j.1471-4159.1977.tb12341.x
pubmed: 141492
Hiro I, Tsugeno Y, Hirashiki I, Ogata F, Ito A (1996) Characterization of rat monoamine oxidase A with noncovalently-bound FAD expressed in yeast cells. J BioChem 120(4):759–765. https://doi.org/10.1093/oxfordjournals.jbchem.a021476
doi: 10.1093/oxfordjournals.jbchem.a021476
pubmed: 8947838
Johns G, Samuel V, Freemantle L, Lewis J, Waddington L (2022) The global prevalence of depression and anxiety among doctors during the covid-19 pandemic: systematic review and meta-analysis. J Affect Disord 298:431–441. https://doi.org/10.1016/j.jad.2021.11.026
doi: 10.1016/j.jad.2021.11.026
pubmed: 34785264
Kabir A, Yusha’u Y, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Zaria AB, Nigeria, Adam U, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria, Ibrahim S, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria, Muhammad M (2022) & Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria. Ameliorative Effect of Rutin Supplement on Chronic Unpredictable Mild Stress-Induced Depressive Phenotypes in Mice. NIgerian Journal of Neuroscience, 13(4), 139–146. https://doi.org/10.47081/njn2022.13.4/004
Kaster MP, Gadotti VM, Calixto JB, Santos ARS, Rodrigues ALS (2012) Depressive-like behavior induced by tumor necrosis factor-α in mice. Neuropharmacology 62(1):419–426. https://doi.org/10.1016/j.neuropharm.2011.08.018
doi: 10.1016/j.neuropharm.2011.08.018
pubmed: 21867719
Kurup ARK, Kurup PA (2002) MEMBRANE na ´ +;-K ´ +; ATPase MEDIATED CASCADE IN BIPOLAR MOOD DISORDER, MAJOR DEPRESSIVE DISORDER, AND SCHIZOPHRENIA RELATIONSHIP TO HEMISPHERIC DOMINANCE. Int J Neurosci 112(8):965–982. https://doi.org/10.1080/00207450290025978
doi: 10.1080/00207450290025978
pubmed: 12448837
Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh Y-HE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Nestler EJ (2017) Sex-specific transcriptional signatures in human depression. Nat Med 23(9):1102–1111. https://doi.org/10.1038/nm.4386
doi: 10.1038/nm.4386
pubmed: 28825715
pmcid: 5734943
Ledebuhr KNB, Nunes GD, Besckow EM, Giehl MR, Godoi B, Bortolatto CF, Brüning CA (2022) Antinociceptive effect of N-(3-(phenylselanyl)prop-2-yn-1-yl)benzamide in mice: involvement of 5-HT1A and 5-HT2A/2 C receptors. Chemico-Biol Interact 359:109918. https://doi.org/10.1016/j.cbi.2022.109918
doi: 10.1016/j.cbi.2022.109918
Liebenberg N, Joca S, Wegener G (2015) Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression. Acta Neuropsychiatrica 27(2):90–96. https://doi.org/10.1017/neu.2014.39
doi: 10.1017/neu.2014.39
pubmed: 25491110
Liu L-L, Li J-M, Su W-J, Wang B, Jiang C-L (2019) Sex differences in depressive-like behaviour may relate to imbalance of microglia activation in the hippocampus. Brain Behav Immun 81:188–197. https://doi.org/10.1016/j.bbi.2019.06.012
doi: 10.1016/j.bbi.2019.06.012
pubmed: 31181346
Loetchutinat C, Kothan S, Dechsupa S, Meesungnoen J, Jay-Gerin J-P, Mankhetkorn S (2005) Spectrofluorometric determination of intracellular levels of reactive oxygen species in drug-sensitive and drug-resistant cancer cells using the 2′,7′-dichlorofluorescein diacetate assay. Radiat Phys Chem 72(2–3):323–331. https://doi.org/10.1016/j.radphyschem.2004.06.011
doi: 10.1016/j.radphyschem.2004.06.011
Luo Y, Kataoka Y, Ostinelli EG, Cipriani A, Furukawa TA (2020) National prescription patterns of antidepressants in the treatment of adults with Major Depression in the US between 1996 and 2015: a Population Representative Survey based analysis. Front Psychiatry 11:35. https://doi.org/10.3389/fpsyt.2020.00035
doi: 10.3389/fpsyt.2020.00035
pubmed: 32116850
pmcid: 7033625
Maripuu M, Bendix M, Öhlund L, Widerström M, Werneke U (2021) Death Associated with Coronavirus (COVID-19) infection in individuals with severe Mental disorders in Sweden during the early months of the Outbreak—An exploratory cross-sectional analysis of a Population-based Register Study. Front Psychiatry 11:609579. https://doi.org/10.3389/fpsyt.2020.609579
doi: 10.3389/fpsyt.2020.609579
pubmed: 33488430
pmcid: 7819873
Mark R, Hensley K, Butterfield D, Mattson M (1995) Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2 + homeostasis and cell death. J Neurosci 15(9):6239–6249. https://doi.org/10.1523/JNEUROSCI.15-09-06239.1995
doi: 10.1523/JNEUROSCI.15-09-06239.1995
pubmed: 7666206
pmcid: 6577674
Markov DD, Novosadova EV (2022) Chronic unpredictable mild stress model of Depression: possible sources of poor reproducibility and latent variables. Biology 11(11):1621. https://doi.org/10.3390/biology11111621
doi: 10.3390/biology11111621
pubmed: 36358321
pmcid: 9687170
Mayanil CSK, Baquer NZ (1985) Kinetics of the mechanism of action of Monoamine Oxidase in the regulation of na
doi: 10.1111/j.1471-4159.1985.tb07107.x
pubmed: 2981100
Mello BSF, Chaves Filho AJM, Custódio CS, Cordeiro RC, Miyajima F, De Sousa FCF, Vasconcelos SMM, De Lucena DF, Macedo D (2018) Sex influences in behavior and brain inflammatory and oxidative alterations in mice submitted to lipopolysaccharide-induced inflammatory model of depression. J Neuroimmunol 320:133–142. https://doi.org/10.1016/j.jneuroim.2018.04.009
doi: 10.1016/j.jneuroim.2018.04.009
pubmed: 29681406
Millan MJ (2005) Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: Focus on Novel therapeutic strategies. Therapies 60(5):441–460. https://doi.org/10.2515/therapie:2005065
doi: 10.2515/therapie:2005065
Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ (2009) AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem 30(16):2785–2791. https://doi.org/10.1002/jcc.21256
doi: 10.1002/jcc.21256
pubmed: 19399780
pmcid: 2760638
OECD (2002) Test No. 423: Acute Oral toxicity - Acute Toxic Class Method. OECD. https://doi.org/10.1787/9789264071001-en
Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):Artigo2. https://doi.org/10.1016/0003-2697(79)90738-3
doi: 10.1016/0003-2697(79)90738-3
Okoh L, Ajayi AM, Ben-Azu B, Akinluyi ET, Emokpae O, Umukoro S (2020) D-Ribose–l-cysteine exhibits adaptogenic-like activity through inhibition of oxido-inflammatory responses and increased neuronal caspase-3 activity in mice exposed to unpredictable chronic mild stress. Mol Biol Rep 47(10):7709–7722. https://doi.org/10.1007/s11033-020-05845-1
doi: 10.1007/s11033-020-05845-1
pubmed: 32959196
Pandey GN, Sharma RP, Janicak PG, Davis JM (1992) Monoamine oxidase and cortisol response in depression and schizophrenia. Psychiatry Res 44(1):1–8. https://doi.org/10.1016/0165-1781(92)90064-A
doi: 10.1016/0165-1781(92)90064-A
pubmed: 1461943
Pavlidi P, Kokras N, Dalla C (2022) Sex Differences in Depression and Anxiety. Em C. Gibson & L. A. M. Galea (Eds.), Sex Differences in Brain Function and Dysfunction (Vol. 62, pp. 103–132). Springer International Publishing. https://doi.org/10.1007/7854_2022_375
Pesarico AP, Sampaio TB, Stangherlin EC, Mantovani AC, Zeni G, Nogueira CW (2014) The antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in the mouse forced swimming test is mediated by serotonergic and dopaminergic systems. Prog Neuropsychopharmacol Biol Psychiatry 54:179–186. https://doi.org/10.1016/j.pnpbp.2014.06.001
doi: 10.1016/j.pnpbp.2014.06.001
pubmed: 24936772
Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera?A visualization system for exploratory research and analysis. J Comput Chem 25(13):1605–1612. https://doi.org/10.1002/jcc.20084
doi: 10.1002/jcc.20084
pubmed: 15264254
Pitzer C, Kurpiers B, Eltokhi A (2022) Sex differences in Depression-Like behaviors in adult mice depend on endophenotype and strain. Front Behav Neurosci 16:838122. https://doi.org/10.3389/fnbeh.2022.838122
doi: 10.3389/fnbeh.2022.838122
pubmed: 35368297
pmcid: 8969904
Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229(2):327–336
pubmed: 596982
Ramsay RR, Basile L, Maniquet A, Hagenow S, Pappalardo M, Saija MC, Bryant SD, Albreht A, Guccione S (2020) Parameters for irreversible inactivation of Monoamine Oxidase. Molecules 25(24):5908. https://doi.org/10.3390/molecules25245908
doi: 10.3390/molecules25245908
pubmed: 33322203
pmcid: 7763263
Ritz T, Trueba AF, Liu J, Auchus RJ, Rosenfield D (2015) Exhaled nitric oxide decreases during academic examination stress in Asthma. Annals Am Thorac Soc 150908081522008. https://doi.org/10.1513/AnnalsATS.201504-213OC
Rohn TT, Hinds TR, Vincenzi FF (1993) Ion transport ATPases as targets for free radical damage. Biochem Pharmacol 46(3):525–534. https://doi.org/10.1016/0006-2952(93)90530-A
doi: 10.1016/0006-2952(93)90530-A
pubmed: 8394084
Rosa AO, Lin J, Calixto JB, Santos ARS, Rodrigues ALS (2003) Involvement of NMDA receptors and l-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice. Behav Brain Res 144(1–2):87–93. https://doi.org/10.1016/S0166-4328(03)00069-X
doi: 10.1016/S0166-4328(03)00069-X
pubmed: 12946598
Samuels BA, Mendez-David I, Faye C, David SA, Pierz KA, Gardier AM, Hen R, David DJ (2016) Serotonin 1A and serotonin 4 receptors: essential mediators of the neurogenic and behavioral actions of antidepressants. Neuroscientist 22(1):26–45. https://doi.org/10.1177/1073858414561303
doi: 10.1177/1073858414561303
pubmed: 25488850
Sanacora G, Zarate CA, Krystal JH, Manji HK (2008) Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat Rev Drug Discovery 7(5):426–437. https://doi.org/10.1038/nrd2462
doi: 10.1038/nrd2462
pubmed: 18425072
Savegnago L, Jesse CR, Pinto LG, Rocha JBT, Nogueira CW, Zeni G (2007) Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats. Prog Neuropsychopharmacol Biol Psychiatry 31(6):1261–1269. https://doi.org/10.1016/j.pnpbp.2007.05.006
doi: 10.1016/j.pnpbp.2007.05.006
pubmed: 17590255
Secci D, Carradori S, Bolasco A, Bizzarri B, D’Ascenzio M, Maccioni E (2012) Discovery and optimization of pyrazoline derivatives as promising Monoamine Oxidase inhibitors. Curr Top Med Chem 12(20):2240–2257. https://doi.org/10.2174/156802612805220057
doi: 10.2174/156802612805220057
pubmed: 23276158
Soliman A, Bagby RM, Wilson AA, Miler L, Clark M, Rusjan P, Sacher J, Houle S, Meyer JH (2011) Relationship of monoamine oxidase A binding to adaptive and maladaptive personality traits. Psychol Med 41(5):1051–1060. https://doi.org/10.1017/S0033291710001601
doi: 10.1017/S0033291710001601
pubmed: 20810002
Son S-Y, Ma J, Kondou Y, Yoshimura M, Yamashita E, Tsukihara T (2008) Structure of human monoamine oxidase A at 2.2-Å resolution: the control of opening the entry for substrates/inhibitors. Proc Natl Acad Sci 105(15):5739–5744. https://doi.org/10.1073/pnas.0710626105
doi: 10.1073/pnas.0710626105
pubmed: 18391214
pmcid: 2311356
Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS (2007) SB-649915-B, a Novel 5-HT1A/B Autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the Rat High Light Social Interaction Test. Neuropsychopharmacology 32(10):2163–2172. https://doi.org/10.1038/sj.npp.1301341
doi: 10.1038/sj.npp.1301341
pubmed: 17356576
Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85(3):367–370. https://doi.org/10.1007/BF00428203
doi: 10.1007/BF00428203
pubmed: 3923523
Tanaka M, Telegdy G (2008) Involvement of adrenergic and serotonergic receptors in antidepressant-like effect of urocortin 3 in a modified forced swimming test in mice. Brain Res Bull 77(5):301–305. https://doi.org/10.1016/j.brainresbull.2008.08.012
doi: 10.1016/j.brainresbull.2008.08.012
pubmed: 18793704
Thankachan AP, Sindhu KS, Krishnan KK, Anilkumar G (2015) A novel and efficient zinc-catalyzed thioetherification of aryl halides. RSC Adv 5(41):32675–32678. https://doi.org/10.1039/C5RA03869C
doi: 10.1039/C5RA03869C
Trott O, Olson AJ (2009) AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry, NA-NA. https://doi.org/10.1002/jcc.21334
Tsugeno Y, Ito A (1997) A key amino acid responsible for substrate selectivity of Monoamine Oxidase A and B. J Biol Chem 272(22):14033–14036. https://doi.org/10.1074/jbc.272.22.14033
doi: 10.1074/jbc.272.22.14033
pubmed: 9162023
Turner TJ, Mokler DJ, Luebke JI (2004) Calcium influx through presynaptic 5-HT3 receptors facilitates GABA release in the hippocampus: in vitro slice and synaptosome studies. Neuroscience 129(3):703–718. https://doi.org/10.1016/j.neuroscience.2004.08.020
doi: 10.1016/j.neuroscience.2004.08.020
pubmed: 15541891
Vasilescu A-N, Mallien A, Pfeiffer N, Lang UE, Gass P, Inta D (2021) Rapastinel alleviates the neurotoxic effect induced by NMDA receptor blockade in the early postnatal mouse brain. Eur Arch Psychiatry Clin NeuroSci 271(8):1587–1591. https://doi.org/10.1007/s00406-020-01180-5
doi: 10.1007/s00406-020-01180-5
pubmed: 32789675
Vieira JO, Duarte JO, Costa-Ferreira W, Morais-Silva G, Marin MT, Crestani CC (2018) Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats. Prog Neuropsychopharmacol Biol Psychiatry 81:426–437. https://doi.org/10.1016/j.pnpbp.2017.08.014
doi: 10.1016/j.pnpbp.2017.08.014
pubmed: 28823849
Walsh RN, Cummins RA (1976) The open-field test: a critical review. Psychol Bull 83(3):482–504. https://doi.org/10.1037/0033-2909.83.3.482
doi: 10.1037/0033-2909.83.3.482
pubmed: 17582919
WHO-World Health Organization (2016) Practice manual for establishing and maintaining surveillance systems for suicide attempts and self-harm. Geneve: http://apps.who.int/iris/bitstream/10665/208895/1/9789241549578_eng.pdf
Willner P, Towell A, Sampson D, Sophokleous S, Muscat R (1987) Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology 93(3). https://doi.org/10.1007/BF00187257
Xiao J (2023) Gender differences in Major Depressive Disorder and relevant interventions. Lecture Notes Educ Psychol Public Media 3(1):356–361. https://doi.org/10.54254/2753-7048/3/2022502
doi: 10.54254/2753-7048/3/2022502
Xing Y, He J, Hou J, Lin F, Tian J, Kurihara H (2013) Gender differences in CMS and the effects of antidepressant venlafaxine in rats. Neurochem Int 63(6):570–575. https://doi.org/10.1016/j.neuint.2013.09.019
doi: 10.1016/j.neuint.2013.09.019
pubmed: 24090637
Yankelevitch-Yahav R, Franko M, Huly A, Doron R (2015) The forced swim test as a model of depressive-like Behavior. J Visualized Experiments 97:52587. https://doi.org/10.3791/52587
doi: 10.3791/52587
Zomkowski ADE, Engel D, Gabilan NH, Rodrigues ALS (2010) Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test. Eur Neuropsychopharmacol 20(11):793–801. https://doi.org/10.1016/j.euroneuro.2010.07.011
doi: 10.1016/j.euroneuro.2010.07.011
pubmed: 20810255