Kinetics and toxicity of nanoplastics in ex vivo exposed human whole blood as a model to understand their impact on human health.

Hemolysis Nanoplastics Oxidative stress Platelets functionality Uptake

Journal

The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500

Informations de publication

Date de publication:
13 Jul 2024
Historique:
received: 29 05 2024
revised: 09 07 2024
accepted: 10 07 2024
medline: 16 7 2024
pubmed: 16 7 2024
entrez: 15 7 2024
Statut: aheadofprint

Résumé

The ubiquitous presence of nanoplastics (NPLs) in the environment is considered of great health concern. Due to their size, NPLs can cross both the intestinal and pulmonary barriers and, consequently, their presence in the blood compartment is expected. Understanding the interactions between NPLs and human blood components is required. In this study, to simulate more adequate real exposure conditions, the whole blood of healthy donors was exposed to five different NPLs: three polystyrene NPLs of approximately 50 nm (aminated PS-NH

Identifiants

DOI: 10.1016/j.scitotenv.2024.174725 PMID: 39009158
pubmed: 39009158
pii: S0048-9697(24)04874-5
doi: 10.1016/j.scitotenv.2024.174725
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

174725

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Auteurs

J Arribas Arranz (JA)

Group of Mutagenesis, Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.

A Villacorta (A)

Group of Mutagenesis, Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain; Facultad de Recursos Naturales Renovables, Universidad Arturo Prat, Iquique, Chile.

L Rubio (L)

Group of Mutagenesis, Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.

A García-Rodríguez (A)

Group of Mutagenesis, Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.

G Sánchez (G)

Institute of Agrochemistry and Food Technology, IATA-CSIC, Av. Agustín Escardino 7, Paterna, Valencia 46980, Spain.

M Llorca (M)

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), 08034 Barcelona, Spain.

M Farre (M)

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), 08034 Barcelona, Spain.

J F Ferrer (JF)

AIMPLAS, Plastics Technology Center, Valencia Parc Tecnologic, 46980 Paterna, Spain.

R Marcos (R)

Group of Mutagenesis, Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain. Electronic address: ricard.marcos@uab.cat.

A Hernández (A)

Group of Mutagenesis, Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain. Electronic address: alba.hernandez@uab.cat.

Classifications MeSH