Evaluation of ophthalmic vascular and neuroretinal alterations in fibromyalgia syndrome: a cross-sectional comparative study.
Angiography
Fibromyalgia
Optical coherence tomography
Optical imaging
Retina
Journal
Rheumatology international
ISSN: 1437-160X
Titre abrégé: Rheumatol Int
Pays: Germany
ID NLM: 8206885
Informations de publication
Date de publication:
16 Jul 2024
16 Jul 2024
Historique:
received:
21
06
2024
accepted:
05
07
2024
medline:
16
7
2024
pubmed:
16
7
2024
entrez:
16
7
2024
Statut:
aheadofprint
Résumé
Fibromyalgia syndrome (FMS) is a prevalent rheumatic disorder, and its pathogenesis includes genetic, neuroendocrine, and autonomic abnormalities, which may impact ocular structures. The aim was to conduct a comparative analysis of the ophthalmic vasculature and the retinal nerve fiber layer (RNFL) thickness between FMS and control groups using optical coherence tomography (OCT) and OCT angiography (OCTA). This cross-sectional comparative study included 43 FMS patients and 40 healthy controls recruited from a tertiary education and research hospital between January 2024 and May 2024. All patients satisfied the 2016 American College of Rheumatology criteria for FMS and consented. OCT and OCTA were used to assess the RNFL thickness and the retinal microvasculature structure. The Fibromyalgia Impact Questionnaire (FIQ) was performed to evaluate disease severity. The study found significantly higher total retinal parafoveal thickness and foveal density in FMS patients (p = 0.017 and p = 0.044, respectively). Nevertheless, there were no significant differences among the groups concerning total retinal foveal thickness, foveal avascular zone characteristics, superficial and deep capillary plexus densities, choriocapillaris flow area, and outer retinal flow area values (p > 0.05). The RNFL thickness in all quadrants did not reveal significant differences between the groups (p > 0.05). Furthermore, there was no significant correlation between FIQ scores and OCTA parameters or RNFL thickness values (p > 0.05). The study revealed slight differences in retinal parafoveal thickness and foveal density in FMS patients, but no substantial vascular or neurodegenerative alterations were observed compared to healthy controls. These data indicate that FMS may not substantially affect ocular structures, contrary to earlier hypotheses.
Identifiants
pubmed: 39012358
doi: 10.1007/s00296-024-05662-w
pii: 10.1007/s00296-024-05662-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Ozturk GY, Arat NB, Ozdemir AA, Bashan I, Kocyigit BF (2024) The effect of earthquake on fibromyalgia: a comparison of patients on medication and without medication. Rheumatol Int. https://doi.org/10.1007/s00296-024-05605-5
doi: 10.1007/s00296-024-05605-5
pubmed: 38914776
pmcid: 11178565
Pérez-Neri I, Sandoval H, Estêvão MD et al (2023) Central and peripheral mechanisms of pain in fibromyalgia: scoping review protocol. Rheumatol Int 43:757–762. https://doi.org/10.1007/s00296-023-05275-9
doi: 10.1007/s00296-023-05275-9
pubmed: 36635578
Bair MJ, Krebs EE (2020) Fibromyalgia. Ann Intern Med 172:ITC33–ITC48. https://doi.org/10.7326/AITC202003030
doi: 10.7326/AITC202003030
pubmed: 32120395
Bailly F (2021) The challenge of differentiating fibromyalgia from small-fiber neuropathy in clinical practice. J Joint Bone Spine 88:105232. https://doi.org/10.1016/j.jbspin.2021.105232
doi: 10.1016/j.jbspin.2021.105232
Coskun Benlidayi I (2019) Role of inflammation in the pathogenesis and treatment of fibromyalgia. Rheumatol Int 39:781–791. https://doi.org/10.1007/s00296-019-04251-6
doi: 10.1007/s00296-019-04251-6
pubmed: 30756137
Kocyigit BF, Akyol A (2023) Coexistence of fibromyalgia syndrome and inflammatory rheumatic diseases, and autonomic cardiovascular system involvement in fibromyalgia syndrome. Clin Rheumatol 42:645–652. https://doi.org/10.1007/s10067-022-06385-8
doi: 10.1007/s10067-022-06385-8
pubmed: 36151442
Gyorfi M, Rupp A, Abd-Elsayed A (2022) Fibromyalgia Pathophysiology Biomedicines 10:3070. https://doi.org/10.3390/biomedicines10123070
doi: 10.3390/biomedicines10123070
pubmed: 36551826
Kong J, Huang Y, Liu J et al (2021) Altered functional connectivity between hypothalamus and limbic system in fibromyalgia. Mol Brain 14:17. https://doi.org/10.1186/s13041-020-00705-2
doi: 10.1186/s13041-020-00705-2
pubmed: 33472674
pmcid: 7816461
Garcia-Hernandez A, de la Coba P, Del Reyes GA (2022) Central sensitisation pain and autonomic deficiencies in fibromyalgia. Clin Exp Rheumatol 40:1202–1209. https://doi.org/10.55563/clinexprheumatol/n280oi
doi: 10.55563/clinexprheumatol/n280oi
pubmed: 35748717
Erten Palu T, Bilgin S (2024) Assessment of ophthalmic vascular changes in fibromyalgia patients using optical coherence tomography angiography: is there a real pathology? JFO Open Ophthalmol 6:100057. https://doi.org/10.1016/j.jfop.2023.100057
doi: 10.1016/j.jfop.2023.100057
Satue M, Seral M, Otin S et al (2014) Retinal thinning and correlation with functional disability in patients with Parkinson’s disease. Br J Ophthalmol 98:350–355. https://doi.org/10.1136/bjophthalmol-2013-304152
doi: 10.1136/bjophthalmol-2013-304152
pubmed: 24276697
Hagag AM, Gao SS, Jia Y, Huang D (2017) Optical coherence tomography angiography: technical principles and clinical applications in ophthalmology. Taiwan J Ophthalmol 7:115–129. https://doi.org/10.4103/tjo.tjo_31_17
doi: 10.4103/tjo.tjo_31_17
pubmed: 28966909
pmcid: 5617355
Garcia-Martin E, Garcia-Campayo J, Puebla-Guedea M et al (2016) Fibromyalgia is correlated with retinal nerve Fiber layer thinning. PLoS ONE 11:e0161574. https://doi.org/10.1371/journal.pone.0161574
doi: 10.1371/journal.pone.0161574
pubmed: 27584145
pmcid: 5008644
Wolfe F, Clauw DJ, Fitzcharles MA et al (2016) 2016 revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum 46:319–329. https://doi.org/10.1016/j.semarthrit.2016.08.012
doi: 10.1016/j.semarthrit.2016.08.012
pubmed: 27916278
Burckhardt CS, Clark SR, Bennett RM (1991) The fibromyalgia impact questionnaire: development and validation. J Rheumatol 18:728–733
pubmed: 1865419
Sarmer S, Ergin S, Yavuzer GM (2000) The validity and reliability of the Turkish version of the Fibromyalgia Impact Questionnaire. Rheumatol Int 20:9–12
doi: 10.1007/s002960000077
pubmed: 11149662
Nassif N, Cense B, Park B et el (2004) In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve. Opt Express 12:367–376. https://doi.org/10.1364/opex.12.000367
doi: 10.1364/opex.12.000367
pubmed: 19474832
Varman A, Muralidharan R, Balakumar D (2017) Optical coherence tomography angiography: a general view.TNOA. J Ophthalmic Sci Res 55:107–112. https://doi.org/10.4103/tjosr.tjosr_21_17
doi: 10.4103/tjosr.tjosr_21_17
Fernandes EA, Wildner P, Oset M et al (2024) Optical coherence tomography angiography as a potential tool in differential diagnosis of multiple sclerosis and rheumatic disorders with central nervous system involvement. Int Ophthalmol 44:281. https://doi.org/10.1007/s10792-024-03217-3
doi: 10.1007/s10792-024-03217-3
pubmed: 38922460
pmcid: 11208227
Fekrazad S, Hassanzadeh G, Salehi MA, Mozafar M, Shahrabi Farahani M, Arevalo JF (2024) Optical coherence tomography angiography measurements in systemic lupus erythematosus: a systematic review and meta-analysis. Surv Ophthalmol S. https://doi.org/10.1016/j.survophthal.2024.04.007 . 0039-6257(24)00047-X.m
doi: 10.1016/j.survophthal.2024.04.007
Koca N, Ayar K, Can ME (2020) Optical coherence tomography angiography findings in axial spondylarthritis. Rheumatol Int 40:901–913. https://doi.org/10.1007/s00296-020-04553-0
doi: 10.1007/s00296-020-04553-0
pubmed: 32219479
Cutolo CA, Cere A, Toma P et al (2024) Peripheral and ocular microvascular alterations in systemic sclerosis: observations from capillaroscopic assessments, perfusion peripheral analysis, and optical coherence tomography angiography. Rheumatol Int 44:107–118. https://doi.org/10.1007/s00296-023-05495-z
doi: 10.1007/s00296-023-05495-z
pubmed: 37978075
Garcia-Martin E, Tello A, Vilades E et al (2022) Diagnostic Ability and Capacity of Optical Coherence Tomography-Angiography to Detect Retinal and Vascular Changes in Patients with Fibromyalgia. J Ophthalmol 2022:3946017. https://doi.org/10.1155/2022/3946017
Urfalıoglu S, Berk E (2022) Assessment of retinal nerve fiber thickness and optic nerve head blood flow in female patients diagnosed with fibromyalgia syndrome. Arq Bras Oftalmol 85:30–36. https://doi.org/10.5935/0004-2749.20220005
doi: 10.5935/0004-2749.20220005
pubmed: 34586226
Sevimli N, Kurna SA, Şilte Karamanlıoğlu AD et al (2023) Characteristics of the retina and choroid in fibromyalgia patients and their correlation with disease severity and quality of life. Photodiagnosis Photodyn Ther 44:103819. https://doi.org/10.1016/j.pdpdt.2023.103819
doi: 10.1016/j.pdpdt.2023.103819
pubmed: 37797910
Seidel MF, Weinreich GF, Stratz T, Müller W (2007) 5-HT3 receptor antagonists regulate autonomic cardiac dysfunction in primary fibromyalgia syndrome. Rheumatol Int 27:1025–1030. https://doi.org/10.1007/s00296-007-0406-6
doi: 10.1007/s00296-007-0406-6
pubmed: 17634903
On AY, Tanigor G, Baydar DA (2022) Relationships of autonomic dysfunction with disease severity and neuropathic pain features in fibromyalgia: is it really a sympathetically maintained neuropathic pain? Korean J Pain 35:327–335. https://doi.org/10.3344/kjp.2022.35.3.327
doi: 10.3344/kjp.2022.35.3.327
pubmed: 35768988
pmcid: 9251392
Gürsoy S, Erdal E, Herken H, Madenci E, Alaşehirli B, Erdal N (2003) Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome. Rheumatol Int 23:104–107. https://doi.org/10.1007/s00296-002-0260-5
doi: 10.1007/s00296-002-0260-5
pubmed: 12739038
Rus A, Molina F, Del Moral ML, Ramírez-Expósito MJ, Martínez-Martos JM (2018) Catecholamine and indolamine pathway: a case-control study in Fibromyalgia. Biol Res Nurs 20:577–586. https://doi.org/10.1177/1099800418787672
doi: 10.1177/1099800418787672
pubmed: 30009619
Boquete L, Vicente MJ, Miguel-Jiménez JM et al (2022) Objective diagnosis of Fibromyalgia using Neuroretinal evaluation and Artificial Intelligence. Int J Clin Health Psychol 22:100294. https://doi.org/10.1016/j.ijchp.2022.100294
doi: 10.1016/j.ijchp.2022.100294
pubmed: 35281771
pmcid: 8873600