Differential Incidence of Contrast-Associated Acute Kidney Injury: Comparing Intravenous and Intraarterial Contrast Administration.

Contrast-associated nephropathy Intravenous contrast Prevention

Journal

Current cardiology reports
ISSN: 1534-3170
Titre abrégé: Curr Cardiol Rep
Pays: United States
ID NLM: 100888969

Informations de publication

Date de publication:
16 Jul 2024
Historique:
accepted: 17 06 2024
medline: 16 7 2024
pubmed: 16 7 2024
entrez: 16 7 2024
Statut: aheadofprint

Résumé

Contrast-associated acute kidney injury (CA-AKI) remains a significant concern in diagnostic and invasive procedures, particularly in the context of iodinated contrast material administration. The traditional definition of CA-AKI, based on serum creatinine elevation following contrast exposure, may not accurately capture its multifactorial nature. Studies have provided new insights into the differential incidence of CA-AKI between intravenous and intraarterial contrast administration, emphasizing the importance of tailored preventative strategies for high-risk procedures. This higher risk may arise from two proposed mechanisms: one implicating free radical formation leading to cytotoxicity and apoptosis in renal cells and another suggesting that contrast media alter renal hemodynamics, particularly in the outer medulla, by constricting the vasa recta and reducing medullary flow. Advances in technology and patient care, including contemporary use of low-osmolar contrast agents and hydration protocols, mitigate CA-AKI risk. Diagnostic and invasive procedures should not be avoided solely due to concerns about renal dysfunction if the patient is likely to benefit clinically.

Identifiants

pubmed: 39012549
doi: 10.1007/s11886-024-02083-w
pii: 10.1007/s11886-024-02083-w
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Maya Guhan (M)

Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA. Maya.guhan@bcm.edu.

Mostafa Shalaby (M)

Division of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, TX, USA.

Tareq Abu Sharifeh (TA)

Division of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, TX, USA.

Amer Abdulla (A)

Division of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, TX, USA.

Hani Jneid (H)

Division of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, TX, USA.

Joseph Allencherril (J)

Division of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, TX, USA.

Classifications MeSH