Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
16 Jul 2024
Historique:
received: 19 01 2024
accepted: 05 07 2024
medline: 17 7 2024
pubmed: 17 7 2024
entrez: 16 7 2024
Statut: epublish

Résumé

Human manganese superoxide dismutase (MnSOD) is a crucial oxidoreductase that maintains the vitality of mitochondria by converting superoxide (O

Identifiants

pubmed: 39013847
doi: 10.1038/s41467-024-50260-w
pii: 10.1038/s41467-024-50260-w
doi:

Substances chimiques

Superoxide Dismutase EC 1.15.1.1
Hydrogen Peroxide BBX060AN9V
Manganese 42Z2K6ZL8P
Superoxides 11062-77-4
Protons 0
Oxygen S88TT14065

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5973

Informations de copyright

© 2024. The Author(s).

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Auteurs

Jahaun Azadmanesh (J)

Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, 68198-6805, USA.

Katelyn Slobodnik (K)

Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, 68198-6805, USA.

Lucas R Struble (LR)

Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, 68198-6805, USA.

William E Lutz (WE)

Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, 68198-6805, USA.

Leighton Coates (L)

Second Target Station, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37831, USA.

Kevin L Weiss (KL)

Neutron Scattering Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37831, USA.

Dean A A Myles (DAA)

Neutron Scattering Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, 37831, USA.

Thomas Kroll (T)

Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, 94025, USA.

Gloria E O Borgstahl (GEO)

Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, 68198-6805, USA. gborgstahl@unmc.edu.

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