Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm.

Humans Schizophrenia / diagnostic imaging Male Female Adult Algorithms Magnetic Resonance Imaging Gray Matter / diagnostic imaging Machine Learning Middle Aged Brain / diagnostic imaging Cross-Sectional Studies Europe Neuroimaging Reproducibility of Results North America Hippocampus / diagnostic imaging

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
17 Jul 2024
Historique:
received: 17 10 2023
accepted: 03 07 2024
medline: 17 7 2024
pubmed: 17 7 2024
entrez: 16 7 2024
Statut: epublish

Résumé

Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts from the ENIGMA, non-ENIGMA cohorts and public datasets. Using the Subtype and Stage Inference (SuStaIn) algorithm, we identify two distinct neurostructural subgroups by mapping the spatial and temporal 'trajectory' of gray matter change in schizophrenia. Subgroup 1 was characterized by an early cortical-predominant loss with enlarged striatum, whereas subgroup 2 displayed an early subcortical-predominant loss in the hippocampus, striatum and other subcortical regions. We confirmed the reproducibility of the two neurostructural subtypes across various sample sites, including Europe, North America and East Asia. This imaging-based taxonomy holds the potential to identify individuals with shared neurobiological attributes, thereby suggesting the viability of redefining existing disorder constructs based on biological factors.

Identifiants

DOI: 10.1038/s41467-024-50267-3 PMID: 39013848
pubmed: 39013848
doi: 10.1038/s41467-024-50267-3
pii: 10.1038/s41467-024-50267-3
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5996

Investigateurs

Andrea de Bartolomeis (A)
Tamsyn E Van Rheenen (TE)

Informations de copyright

© 2024. The Author(s).

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Auteurs

Yuchao Jiang (Y)

Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
ORCID: 0000-0001-7012-0559

Cheng Luo (C)

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China.
High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Research Unit of NeuroInformation (2019RU035), Chinese Academy of Medical Sciences, Chengdu, China.
ORCID: 0000-0003-0524-5886

Jijun Wang (J)

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Lena Palaniyappan (L)

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Canada.
ORCID: 0000-0003-1640-7182

Xiao Chang (X)

Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
ORCID: 0000-0002-8076-8110

Shitong Xiang (S)

Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
ORCID: 0000-0002-5513-4714

Jie Zhang (J)

Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
ORCID: 0000-0002-5016-9192

Mingjun Duan (M)

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China.

Huan Huang (H)

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China.

Christian Gaser (C)

Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Department of Neurology, Jena University Hospital, Jena, Germany.
German Center for Mental Health (DZPG), Site Jena-Magdeburg-Halle, Magdeburg, Germany.
ORCID: 0000-0002-9940-099X

Kiyotaka Nemoto (K)

Department of Psychiatry, Division of Clinical Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
ORCID: 0000-0001-8623-9829

Kenichiro Miura (K)

Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
ORCID: 0000-0002-3722-7837

Ryota Hashimoto (R)

Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
ORCID: 0000-0002-5941-4238

Lars T Westlye (LT)

Department of Psychology, University of Oslo, Oslo, Norway.
NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0001-8644-956X

Genevieve Richard (G)

Department of Psychology, University of Oslo, Oslo, Norway.
NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0001-6475-2576

Sara Fernandez-Cabello (S)

Department of Psychology, University of Oslo, Oslo, Norway.
NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway.

Nadine Parker (N)

NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
ORCID: 0000-0002-8369-0152

Ole A Andreassen (OA)

NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
ORCID: 0000-0002-4461-3568

Tilo Kircher (T)

Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.

Igor Nenadić (I)

Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.
ORCID: 0000-0002-0749-7473

Frederike Stein (F)

Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.

Florian Thomas-Odenthal (F)

Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.
ORCID: 0000-0003-4912-8307

Lea Teutenberg (L)

Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.

Paula Usemann (P)

Department of Psychiatry and Psychotherapy, Philipps Universität Marburg, Rudolf-Bultmann-Str. 8, Marburg, Germany.

Udo Dannlowski (U)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Tim Hahn (T)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.
ORCID: 0000-0001-6541-3795

Dominik Grotegerd (D)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.
ORCID: 0000-0001-8718-0128

Susanne Meinert (S)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.
Institute for Translational Neuroscience, University of Münster, Münster, Germany.
ORCID: 0000-0003-2177-7161

Rebekka Lencer (R)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.
Department of Psychiatry and Psychotherapie and Center for Brain, Behavior and Metabolism, Lübeck University, Lübeck, Germany.
Institute for Transnational Psychiatry and Otto Creutzfeldt Center for Behavioral and Cognitive Neuroscience, University of Münster, Münster, Germany.
ORCID: 0000-0003-4032-7297

Yingying Tang (Y)

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
ORCID: 0000-0002-4705-3682

Tianhong Zhang (T)

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
ORCID: 0000-0002-5379-7119

Chunbo Li (C)

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Weihua Yue (W)

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, PR China.
Chinese Institute for Brain Research, Beijing, PR China.
PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, PR China.
ORCID: 0000-0002-1201-8465

Yuyanan Zhang (Y)

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, PR China.
ORCID: 0000-0002-0474-1135

Xin Yu (X)

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, PR China.
ORCID: 0000-0003-3983-4937

Enpeng Zhou (E)

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, PR China.

Ching-Po Lin (CP)

Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Shih-Jen Tsai (SJ)

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
ORCID: 0000-0002-9987-022X

Amanda L Rodrigue (AL)

Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-3403-6349

David Glahn (D)

Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Godfrey Pearlson (G)

Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA.

John Blangero (J)

Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas of the Rio Grande Valley, Brownsville, TX, USA.
ORCID: 0000-0001-6250-5723

Andriana Karuk (A)

FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.
ORCID: 0000-0002-2876-7268

Edith Pomarol-Clotet (E)

FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.

Raymond Salvador (R)

FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.

Paola Fuentes-Claramonte (P)

FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.

María Ángeles Garcia-León (MÁ)

FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.

Gianfranco Spalletta (G)

Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy.
ORCID: 0000-0002-7432-4249

Fabrizio Piras (F)

Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy.
ORCID: 0000-0003-3566-5494

Daniela Vecchio (D)

Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy.

Nerisa Banaj (N)

Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy.
ORCID: 0000-0002-6317-8549

Jingliang Cheng (J)

Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
ORCID: 0000-0002-6996-329X

Zhening Liu (Z)

National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.

Jie Yang (J)

National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China.

Ali Saffet Gonul (AS)

Ege University School of Medicine Department of Psychiatry, SoCAT Lab, Izmir, Turkey.

Ozgul Uslu (O)

Ege University Institute of Health Sciences Department of Neuroscience, Izmir, Turkey.

Birce Begum Burhanoglu (BB)

Ege University Institute of Health Sciences Department of Neuroscience, Izmir, Turkey.

Aslihan Uyar Demir (A)

Ege University School of Medicine Department of Psychiatry, SoCAT Lab, Izmir, Turkey.
ORCID: 0000-0002-0856-4260

Kelly Rootes-Murdy (K)

Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) [Georgia State University, Georgia Institute of Technology, Emory University], Atlanta, GA, USA.

Vince D Calhoun (VD)

Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) [Georgia State University, Georgia Institute of Technology, Emory University], Atlanta, GA, USA.
ORCID: 0000-0001-9058-0747

Kang Sim (K)

West Region, Institute of Mental Health, Singapore, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Melissa Green (M)

School of Clinical Medicine, University of New South Wales, SYD, Australia.
ORCID: 0000-0002-9361-4874

Yann Quidé (Y)

School of Psychology, University of New South Wales, SYD, Australia.
ORCID: 0000-0002-8569-7139

Young Chul Chung (YC)

Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea.
Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.

Woo-Sung Kim (WS)

Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.

Scott R Sponheim (SR)

Minneapolis VA Medical Center, University of Minnesota, Minneapolis, MN, USA.
Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
ORCID: 0000-0002-2782-0856

Caroline Demro (C)

Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.

Ian S Ramsay (IS)

Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.

Felice Iasevoli (F)

Section of Psychiatry - Department of Neuroscience, University "Federico II", Naples, Italy.
ORCID: 0000-0002-7051-5013

Andrea de Bartolomeis (A)

Section of Psychiatry - Department of Neuroscience, University "Federico II", Naples, Italy.
ORCID: 0000-0002-3188-5652

Annarita Barone (A)

Section of Psychiatry - Department of Neuroscience, University "Federico II", Naples, Italy.
ORCID: 0000-0002-2751-5683

Mariateresa Ciccarelli (M)

Section of Psychiatry - Department of Neuroscience, University "Federico II", Naples, Italy.
ORCID: 0000-0001-8944-414X

Arturo Brunetti (A)

Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.

Sirio Cocozza (S)

Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
ORCID: 0000-0002-0300-5160

Giuseppe Pontillo (G)

Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
ORCID: 0000-0001-5425-1890

Mario Tranfa (M)

Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.

Min Tae M Park (MTM)

Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, TO, Canada.
Centre for Addiction and Mental Health, TO, Canada.
ORCID: 0000-0002-4268-7432

Matthias Kirschner (M)

Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital University of Zurich, Zurich, Switzerland.
ORCID: 0000-0002-9486-1439

Foivos Georgiadis (F)

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital University of Zurich, Zurich, Switzerland.

Stefan Kaiser (S)

Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland.

Tamsyn E Van Rheenen (TE)

Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, MEL, Australia.
Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, MEL, Australia.

Susan L Rossell (SL)

Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, MEL, Australia.

Matthew Hughes (M)

Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, MEL, Australia.
ORCID: 0000-0001-5057-5556

William Woods (W)

Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, MEL, Australia.
ORCID: 0000-0001-6653-6105

Sean P Carruthers (SP)

Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, MEL, Australia.

Philip Sumner (P)

Centre for Mental Health and Brain Sciences, School of Health Sciences, Swinburne University, MEL, Australia.

Elysha Ringin (E)

National Institute of Mental Health, Klecany, Czech Republic.

Filip Spaniel (F)

National Institute of Mental Health, Klecany, Czech Republic.

Antonin Skoch (A)

National Institute of Mental Health, Klecany, Czech Republic.
MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
ORCID: 0000-0002-1739-3256

David Tomecek (D)

National Institute of Mental Health, Klecany, Czech Republic.
Institute of Computer Science, Czech Academy of Sciences, Prague, Czech Republic.
Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.

Philipp Homan (P)

Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Neuroscience Center Zurich, University of Zurich & Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.
ORCID: 0000-0001-9034-148X

Stephanie Homan (S)

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, Zurich, Switzerland.
Experimental Psychopathology and Psychotherapy, Department of Psychology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0003-1449-7508

Wolfgang Omlor (W)

Psychiatric Hospital, University of Zurich, Zurich, Switzerland.

Giacomo Cecere (G)

Psychiatric Hospital, University of Zurich, Zurich, Switzerland.

Dana D Nguyen (DD)

Department of Pediatrics, University of California Irvine, Irvine, CA, USA.

Adrian Preda (A)

Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.

Sophia I Thomopoulos (SI)

Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Neda Jahanshad (N)

Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Long-Biao Cui (LB)

Department of Clinical Psychology, Fourth Military Medical University, Xi'an, PR China.
ORCID: 0000-0002-0784-181X

Dezhong Yao (D)

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, China.
High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Research Unit of NeuroInformation (2019RU035), Chinese Academy of Medical Sciences, Chengdu, China.
ORCID: 0000-0002-8042-879X

Paul M Thompson (PM)

Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Jessica A Turner (JA)

Psychiatry and Behavioral Health, Ohio State Wexner Medical Center, Columbus, OH, USA.
ORCID: 0000-0003-0076-8434

Theo G M van Erp (TGM)

Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine Hall, room 109, Irvine, CA, USA.
Center for the Neurobiology of Learning and Memory, University of California Irvine, 309 Qureshey Research Lab, Irvine, CA, USA.
ORCID: 0000-0002-2465-2797

Wei Cheng (W)

Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
Shanghai Medical College and Zhongshan Hospital Immunotherapy Technology Transfer Center, Shanghai, China.
Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Fudan ISTBI-ZJNU Algorithm Centre for Brain-Inspired Intelligence, Zhejiang Normal University, Jinhua, China.
ORCID: 0000-0003-1118-1743

Jianfeng Feng (J)

Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China. jffeng@fudan.edu.cn.
Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China. jffeng@fudan.edu.cn.
Fudan ISTBI-ZJNU Algorithm Centre for Brain-Inspired Intelligence, Zhejiang Normal University, Jinhua, China. jffeng@fudan.edu.cn.
MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. jffeng@fudan.edu.cn.
Zhangjiang Fudan International Innovation Center, Shanghai, China. jffeng@fudan.edu.cn.
School of Data Science, Fudan University, Shanghai, China. jffeng@fudan.edu.cn.
Department of Computer Science, University of Warwick, Coventry, UK. jffeng@fudan.edu.cn.
ORCID: 0000-0002-8890-8288

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance grise › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Intelligence artificielle › Apprentissage machine › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Régions géographiques › Europe › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › Neurostructural subgroup in 4291 individuals...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Neurostructural subgroup in 4291 individuals...