Anti-inflammatory response to 1,8-Cineol and associated microbial communities in Otitis media patients.
1,8-Cineol
Antibiotic resistance
Chronic otitis media
Clinical outcome
Eucalyptus oil
Inflammation
Microbiota
Pathogens
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 Jul 2024
16 Jul 2024
Historique:
received:
18
03
2024
accepted:
11
07
2024
medline:
17
7
2024
pubmed:
17
7
2024
entrez:
16
7
2024
Statut:
epublish
Résumé
Chronic Otitis Media (COM) is defined as long term inflammation and colonization with pathogenic bacteria due to a defect or retraction of the tympanic membrane. Surgical interventions are often augmented by antibiotic resistance development and therefore, off-label treatment using the natural drug 1,8-Cineol was carried out. All COM patients underwent antibiotic therapy and middle ear surgery and developed antibiotic resistances. Microbiological investigations from the auditory canal and stool samples were performed in correlation with the clinical course. Therapy of COM patients with 1,8-Cineol revealed a clear reduction of inflammatory microbes P. aeruginosa and Proteus mirabilis in ear samples as well as intestinal Prevotella copri, which was associated with an improved clinical outcome in certain individuals. The present off-label study revealed manifold anti-inflammatory effects of the natural monoterpene 1,8-Cineol in Otitis media patients. A better understanding of the underlying mechanisms will improve the current treatment options and possible forms of application of this natural drug.
Identifiants
pubmed: 39014066
doi: 10.1038/s41598-024-67498-5
pii: 10.1038/s41598-024-67498-5
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
16362Subventions
Organisme : Cassella-med GmbH & Co. KG, Cologne, Germany
ID : FDE00400/01
Organisme : German Center for Infection Research
ID : TTU 08.826
Informations de copyright
© 2024. The Author(s).
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