The interactive effects of different exercises and hawthorn consumption on the pain threshold of TMT-induced Alzheimer male rats.
Hawthorn
Alzheimer's disease
Exercise
Pain threshold
Journal
The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417
Informations de publication
Date de publication:
16 Jul 2024
16 Jul 2024
Historique:
received:
06
02
2024
accepted:
29
05
2024
medline:
17
7
2024
pubmed:
17
7
2024
entrez:
16
7
2024
Statut:
epublish
Résumé
Exercise increases the pain threshold in healthy people. However, the pain threshold modulation effect of exercise and hawthorn is unclear because of its potential benefits in people with persistent pain, including those with Alzheimer's disease. Accordingly, after the induction of Alzheimer's disease by trimethyl chloride, male rats with Alzheimer's disease were subjected to a 12-week training regimen consisting of resistance training, swimming endurance exercises, and combined exercises. In addition, hawthorn extract was orally administered to the rats. Then, their pain threshold was evaluated using three Tail-flick, Hot-plate, and Formalin tests. Our results showed that Alzheimer's decreased the pain threshold in all three behavioral tests. Combined exercise with hawthorn consumption had the most statistically significant effect on Alzheimer's male rats' pain threshold in all three experiments. A combination of swimming endurance and resistance exercises with hawthorn consumption may modulate hyperalgesia in Alzheimer's rats. Future studies need to determine the effects of these factors on the treatment and/or management of painful conditions.
Identifiants
pubmed: 39014320
doi: 10.1186/s12576-024-00925-4
pii: 10.1186/s12576-024-00925-4
doi:
Substances chimiques
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
36Informations de copyright
© 2024. The Author(s).
Références
Merskey H (1994) Part III pain terms, a current list with definitions and notes on usage. Classification of chronic pain-descriptions of chronic pain syndromes and definitions of pain terms. 207–214
Jones A, Kulkarni B, Derbyshire S (2003) Pain mechanisms and their disorders: imaging in clinical neuroscience. Br Med Bull 65:83–93
pubmed: 12697618
doi: 10.1093/bmb/65.1.83
Scherder EJ, Sergeant JA, Swaab DF (2003) Pain processing in dementia and its relation to neuropathology. Lancet Neurol 2:677–686
pubmed: 14572736
doi: 10.1016/S1474-4422(03)00556-8
Song W-J, Yun J-H, Jeong M-S, Kim K-N, Shin T, Kim H-C, Wie M-B (2021) Inhibitors of lipoxygenase and cyclooxygenase-2 attenuate trimethyltin-induced neurotoxicity through regulating oxidative stress and pro-inflammatory cytokines in human neuroblastoma SH-SY5Y Cells. Brain Sci 11:1116
pubmed: 34573138
pmcid: 8468241
doi: 10.3390/brainsci11091116
Wang Z, Xiong L, Zu H (2017) Toxic leukoencephalopathy and hypokalemia due to exposure to trimethyltin. J Clin Neurol (Seoul, Korea) 13:298
doi: 10.3988/jcn.2017.13.3.298
Ichihara G, Iida M, Watanabe E, Fujie T, Kaji T, Lee E, Kim Y (2019) Urinary trimethyl tin reflects blood trimethyl tin in workers recycling organotins. J Occup Health 61:257–260
pubmed: 30924213
pmcid: 6499364
doi: 10.1002/1348-9585.12052
Silakhori S, Hosseinzadeh H, Shaebani Behbahani F, Mehri S (2019) Neuroprotective effect of clavulanic acid on trimethyltin (TMT)-induced cytotoxicity in PC12 cells. Drug Chem Toxicol 42:187–193
pubmed: 29764237
doi: 10.1080/01480545.2018.1468772
Park S-Y, Yang H, Ye M, Liu X, Shim I, Chang Y-T, Bae H (2022) Neuroprotective effects of ex vivo-expanded regulatory T cells on trimethyltin-induced neurodegeneration in mice. J Neuroinflamm 19:143
doi: 10.1186/s12974-022-02512-z
Chvojkova M, Kubova H, Vales K (2021) Effects of dizocilpine, midazolam and their co-application on the trimethyltin (TMT)-induced rat model of cognitive deficit. Brain Sci 11:400
pubmed: 33809889
pmcid: 8004281
doi: 10.3390/brainsci11030400
Stekic A, Zeljkovic M, Zaric Kontic M, Mihajlovic K, Adzic M, Stevanovic I, Ninkovic M, Grkovic I, Ilic TV, Nedeljkovic N (2022) Intermittent theta burst stimulation ameliorates cognitive deficit and attenuates neuroinflammation via PI3K/Akt/mTOR signaling pathway in Alzheimer’s-like disease model. Front Aging Neurosci 14:889983
pubmed: 35656538
pmcid: 9152158
doi: 10.3389/fnagi.2022.889983
González LÁ (2015) The neurologist facing pain in dementia. Neurología (English Edition) 30:574–585
doi: 10.1016/j.nrleng.2011.01.015
Xu H, Yue C, Chen L (2019) Post-transcriptional regulation of soluble guanylate cyclase that governs neuropathic pain in Alzheimer’s disease. J Alzheimers Dis 71:1331–1338
pubmed: 31524174
doi: 10.3233/JAD-190743
Nelson PT, Braak H, Markesbery WR (2009) Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J Neuropathol Exp Neurol 68:1–14
pubmed: 19104448
doi: 10.1097/NEN.0b013e3181919a48
Cole LJ, Farrell MJ, Duff EP, Barber JB, Egan GF, Gibson SJ (2006) Pain sensitivity and fMRI pain-related brain activity in Alzheimer’s disease. Brain 129:2957–2965
pubmed: 16951408
doi: 10.1093/brain/awl228
Corbett A, Husebo B, Malcangio M, Staniland A, Cohen-Mansfield J, Aarsland D, Ballard C (2012) Assessment and treatment of pain in people with dementia. Nat Rev Neurol 8:264–274
pubmed: 22487749
doi: 10.1038/nrneurol.2012.53
Sampson EL, White N, Lord K, Leurent B, Vickerstaff V, Scott S, Jones L (2015) Pain, agitation, and behavioural problems in people with dementia admitted to general hospital wards: a longitudinal cohort study. Pain 156:675
pubmed: 25790457
pmcid: 4381983
doi: 10.1097/j.pain.0000000000000095
Stubbs B, Binnekade T, Eggermont L, Sepehry AA, Patchay S, Schofield P (2014) Pain and the risk for falls in community-dwelling older adults: systematic review and meta-analysis. Arch Phys Med Rehabil 95(175–187):e179
Husebo B, Ballard C, Aarsland D (2011) Pain treatment of agitation in patients with dementia: a systematic review. Int J Geriatr Psychiatry 26:1012–1018
pubmed: 21308784
doi: 10.1002/gps.2649
Pieper MJ, van Dalen-Kok AH, Francke AL, van der Steen JT, Scherder EJ, Husebø BS, Achterberg WP (2013) Interventions targeting pain or behaviour in dementia: a systematic review. Ageing Res Rev 12:1042–1055
pubmed: 23727161
doi: 10.1016/j.arr.2013.05.002
Hunt LJ, Covinsky KE, Yaffe K, Stephens CE, Miao Y, Boscardin WJ, Smith AK (2015) Pain in community-dwelling older adults with dementia: results from the National Health and Aging Trends Study. J Am Geriatr Soc 63:1503–1511
pubmed: 26200445
pmcid: 4778418
doi: 10.1111/jgs.13536
Hoffmann F, van den Bussche H, Wiese B, Glaeske G, Kaduszkiewicz H (2014) Diagnoses indicating pain and analgesic drug prescription in patients with dementia: a comparison to age-and sex-matched controls. BMC Geriatr 14:1–8
doi: 10.1186/1471-2318-14-20
Borg C, Sala E, Chainay H, Labouré J, Getenet JC, Dorey JM, Laurent B, Rouch I (2021) How do patients with Alzheimer’s disease imagine their pain? Eur J Pain 25:466–472
pubmed: 33078485
doi: 10.1002/ejp.1685
De Tommaso M, Arendt-Nielsen L, Defrin R, Kunz M, Pickering G, Valeriani M (2016) Pain in neurodegenerative disease: current knowledge and future perspectives. Behav Neurol. https://doi.org/10.1155/2016/7576292
doi: 10.1155/2016/7576292
pubmed: 27418720
pmcid: 4932155
Wu C, Yang L, Tucker D, Dong Y, Zhu L, Duan R, Liu TC-Y, Zhang Q (2018) Beneficial effects of exercise pretreatment in a sporadic Alzheimer’s rat model. Med Sci Sports Exerc 50:945
pubmed: 29232315
pmcid: 5899011
doi: 10.1249/MSS.0000000000001519
Koltyn KF (2000) Analgesia following exercise. Sports Med 29:85–98
pubmed: 10701712
doi: 10.2165/00007256-200029020-00002
Schmitt A, Wallat D, Stangier C, Martin JA, Schlesinger-Irsch U, Boecker H (2020) Effects of fitness level and exercise intensity on pain and mood responses. Eur J Pain 24:568–579
pubmed: 31738468
doi: 10.1002/ejp.1508
Stubbs B, Thompson T, Solmi M, Vancampfort D, Sergi G, Luchini C, Veronese N (2016) Is pain sensitivity altered in people with Alzheimer’s disease? A systematic review and meta-analysis of experimental pain research. Exp Gerontol 82:30–38
pubmed: 27262688
doi: 10.1016/j.exger.2016.05.016
Huang X-X, Xu Y, Bai M, Zhou L, Song S-J, Wang X-B (2018) Lignans from the seeds of Chinese hawthorn (Crataegus pinnatifida var. major NE Br.) against β-amyloid aggregation. Nat Prod Res 32:1706–1713
pubmed: 29115158
doi: 10.1080/14786419.2017.1399378
Williams RJ, Spencer JP (2012) Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radic Biol Med 52:35–45
pubmed: 21982844
doi: 10.1016/j.freeradbiomed.2011.09.010
Rao PN, Mainkar O, Bansal N, Rakesh N, Haffey P, Urits I, Orhurhu V, Kaye AD, Urman RD, Gulati A (2021) Flavonoids in the treatment of neuropathic pain. Curr Pain Headache Rep 25:1–10
doi: 10.1007/s11916-021-00959-y
Ferraz CR, Carvalho TT, Manchope MF, Artero NA, Rasquel-Oliveira FS, Fattori V, Casagrande R, Verri WA Jr (2020) Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development. Molecules 25:762
pubmed: 32050623
pmcid: 7037709
doi: 10.3390/molecules25030762
Basu P, Maier C, Basu A (2021) Effects of curcumin and its different formulations in preclinical and clinical studies of peripheral neuropathic and postoperative pain: a comprehensive review. Int J Mol Sci 22:4666
pubmed: 33925121
pmcid: 8125634
doi: 10.3390/ijms22094666
Cravello L, Di Santo S, Varrassi G, Benincasa D, Marchettini P, de Tommaso M, Shofany J, Assogna F, Perotta D, Palmer K (2019) Chronic pain in the elderly with cognitive decline: a narrative review. Pain Therapy 8:53–65
pubmed: 30666612
pmcid: 6513941
doi: 10.1007/s40122-019-0111-7
van Kooten J, Binnekade TT, Van Der Wouden JC, Stek ML, Scherder EJ, Husebø BS, Smalbrugge M, Hertogh CM (2016) A review of pain prevalence in Alzheimer’s, vascular, frontotemporal and Lewy body dementias. Dement Geriatr Cogn Disord 41:220–232
pubmed: 27160163
doi: 10.1159/000444791
Lee S, Yang M, Kim J, Kang S, Kim J, Kim J-C, Jung C, Shin T, Kim S-H, Moon C (2016) Trimethyltin-induced hippocampal neurodegeneration: a mechanism-based review. Brain Res Bull 125:187–199
pubmed: 27450702
doi: 10.1016/j.brainresbull.2016.07.010
Kaur S, Chhabra R, Nehru B (2013) Ginkgo biloba extract attenuates hippocampal neuronal loss and cognitive dysfunction resulting from trimethyltin in mice. Phytomedicine 20:178–186
pubmed: 23177260
doi: 10.1016/j.phymed.2012.10.003
Malekzadeh S, Edalatmanesh MA, Mehrabani D, Shariati M (2017) Drugs induced Alzheimer’s disease in animal model. Galen Med J 6:185–196
doi: 10.31661/gmj.v6i3.820
Nurmasitoh T, Sari DCR, Susilowati R (2023) Moderate-intensity intermittent exercise prevents memory deficit, hippocampal neuron loss, and elevated level of Alzheimer’s dementia markers in the hippocampus of trimethyltin-induced rats. Ann Anat-Anatomischer Anzeiger 249:152103
doi: 10.1016/j.aanat.2023.152103
Mataram MBA, Hening P, Harjanti FN, Karnati S, Wasityastuti W, Nugrahaningsih DAA, Kusindarta DL, Wihadmadyatami H (2021) The neuroprotective effect of ethanolic extract Ocimum sanctum Linn. in the regulation of neuronal density in hippocampus areas as a central autobiography memory on the rat model of Alzheimer’s disease. J Chem Neuroanat 111:101885
pubmed: 33188864
doi: 10.1016/j.jchemneu.2020.101885
Bancroft JD, Gamble M (2008) Theory and practice of histological techniques. Elsevier Health Sciences
Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR (1989) Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice. Acta Diabetol Latina 26:51–55
doi: 10.1007/BF02581196
Stanojevic D, Jakovljevic V, Barudzic N, Zivkovic V, Srejovic I, Ilic KP, Cubrilo D, Ahmetovic Z, Peric D, Rosic M (2016) Overtraining does not induce oxidative stress and inflammation in blood and heart of rats. Physiol Res 65:81
pubmed: 26596327
doi: 10.33549/physiolres.933058
Jafarzadeh G, Shakerian S, Farbood Y, Ghanbarzadeh M (2021) Effects of eight weeks of resistance exercises on neurotrophins and trk receptors in alzheimer model male wistar rats. Basic Clin Neurosci 12:349
pubmed: 34917294
pmcid: 8666928
D’Amour FE, Smith DL (1941) A method for determining loss of pain sensation. J Pharmacol Exp Ther 72:74–79
Esmaeili-Mahani S, Fereidoni M, Javan M, Maghsoudi N, Motamedi F, Ahmadiani A (2007) Nifedipine suppresses morphine-induced thermal hyperalgesia: evidence for the role of corticosterone. Eur J Pharmacol 567:95–101
pubmed: 17466971
doi: 10.1016/j.ejphar.2007.03.042
Esmaeili-Mahani S, Rezaeezadeh-Roukerd M, Esmaeilpour K, Abbasnejad M, Rasoulian B, Sheibani V, Kaeidi A, Hajializadeh Z (2010) Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats. J Ethnopharmacol 132:200–205
pubmed: 20713147
doi: 10.1016/j.jep.2010.08.013
Dubuisson D, Dennis SG (1977) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4:161–174
pubmed: 564014
doi: 10.1016/0304-3959(77)90130-0
Kerckhove N, Bornier N, Mulliez A, Elyn A, Teixeira S, Authier N, Bertin C, Chenaf C (2023) Prevalence of chronic pain among people with dementia: a nationwide study using french administrative data. Am J Geriatr Psychiatry 31:1149–1163
pubmed: 37468390
doi: 10.1016/j.jagp.2023.06.015
Dabney C (2023) Understanding pain in Alzheimer's disease in anesthesia. AANA J 91
Aman Y, Pitcher T, Ballard C, Malcangio M (2019) Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer’s disease. Eur J Pain 23:91–106
pubmed: 29987897
doi: 10.1002/ejp.1288
Benedetti F, Vighetti S, Ricco C, Lagna E, Bergamasco B, Pinessi L, Rainero I (1999) Pain threshold and tolerance in Alzheimer’s disease. Pain 80:377–382
pubmed: 10204751
doi: 10.1016/S0304-3959(98)00228-0
Wehe S (2013) Analyse der optimalen Stimulationstemperatur zur Messung der Schmerztoleranz. Niedersächsische Staats-und Universitätsbibliothek Göttingen
Jensen-Dahm C, Werner MU, Dahl JB, Jensen TS, Ballegaard M, Hejl A-M, Waldemar G (2014) Quantitative sensory testing and pain tolerance in patients with mild to moderate Alzheimer disease compared to healthy control subjects. PAIN® 155:1439–1445
pubmed: 24412285
doi: 10.1016/j.pain.2013.12.031
Liu P, Yang B, Kallio H (2010) Characterization of phenolic compounds in Chinese hawthorn (Crataegus pinnatifida Bge. var. major) fruit by high performance liquid chromatography–electrospray ionization mass spectrometry. Food Chem 121:1188–1197
doi: 10.1016/j.foodchem.2010.02.002
Hudson MB, Hosick PA, McCaulley GO, Schrieber L, Wrieden J, Mcanulty SR, Triplett NT, Mcbride JM, Quindry JC (2008) The effect of resistance exercise on humoral markers of oxidative stress. Med Sci Sports Exerc 40:542
pubmed: 18379219
doi: 10.1249/MSS.0b013e31815daf89
Commenges D, Scotet V, Renaud S, Jacqmin-Gadda H, Barberger-Gateau P, Dartigues J-F (2000) Intake of flavonoids and risk of dementia. Eur J Epidemiol 16:357–363
pubmed: 10959944
doi: 10.1023/A:1007614613771
Rasoulijazi H, Joghataei M, Noubakht M, Roughani M (2007) The beneficial effect of (-)-epigallocatechin-3-gallate in an experimental model of Alzheimer’s disease in rat: a behavioral analysis
Basu P, Basu A (2020) In vitro and in vivo effects of flavonoids on peripheral neuropathic pain. Molecules 25:1171
pubmed: 32150953
pmcid: 7179245
doi: 10.3390/molecules25051171
Harborne JB, Williams CA (2000) Advances in flavonoid research since 1992. Phytochemistry 55:481–504
pubmed: 11130659
doi: 10.1016/S0031-9422(00)00235-1
Ye G, Lin C, Zhang Y, Ma Z, Chen Y, Kong L, Yuan L, Ma T (2021) Quercetin alleviates neuropathic pain in the rat CCI model by mediating AMPK/MAPK pathway. J Pain Res 14:1289–1301
pubmed: 34040433
pmcid: 8141401
doi: 10.2147/JPR.S298727
Bagdas D, Gul Z, Meade JA, Cam B, Cinkilic N, Gurun MS (2020) Pharmacologic overview of chlorogenic acid and its metabolites in chronic pain and inflammation. Curr Neuropharmacol 18:216–228
pubmed: 31631820
pmcid: 7327949
doi: 10.2174/1570159X17666191021111809
Wang J, Chen Z-F, He C-X, Wang L-L, Zheng J-H, Zhang H, Wang Z-L, Lu Y-P (2018) The effects of anthocyanin on chronic inflammatory pain induced by complete Freund’s adjuvant and its mechanism. Zhongguo Ying Yong Sheng li xue za zhi Zhongguo Yingyong Shenglixue Zazhi Chin J Appl Physiol 34:476–480
Baydas G, Canatan H, Turkoglu A (2002) Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus. J Pineal Res 32:225–230
pubmed: 11982791
doi: 10.1034/j.1600-079X.2002.01856.x
Koltyn KF, Umeda M (2007) Contralateral attenuation of pain after short-duration submaximal isometric exercise. J Pain 8:887–892
pubmed: 17681886
doi: 10.1016/j.jpain.2007.06.003
Hayes C, Kriska A (2008) Role of physical activity in diabetes management and prevention. J Am Diet Assoc 108:S19–S23
pubmed: 18358249
doi: 10.1016/j.jada.2008.01.016
Willow M, Carmody J, Carroll P (1980) The effects of swimming in mice on pain perception and sleeping time in response to hypnotic drugs. Life Sci 26:219–224
pubmed: 7360004
doi: 10.1016/0024-3205(80)90296-9
Wu B, Zhou L, Chen C, Wang J, Hu L, Wang X (2022) Effects of exercise-induced hypoalgesia and its neural mechanisms. Med Sci Sports Exerc 54:220–231
pubmed: 34468414
doi: 10.1249/MSS.0000000000002781
Pugh CJ, Sprung VS, Ono K, Spence AL, Thijssen DH, Carter HH, Green DJ (2015) The effect of water immersion during exercise on cerebral blood flow. Med Sci Sports Exerc 47:299–306
pubmed: 24977699
doi: 10.1249/MSS.0000000000000422
Hosseini SA, Salehi OR, Farzanegi P, Farkhaie F, Darvishpour AR, Roozegar S (2020) Interactive effects of endurance training and royal jelly consumption on motor balance and pain threshold in animal model of the alzheimer disease. Arch Neurosci. https://doi.org/10.5812/ans.91857
doi: 10.5812/ans.91857