Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase.


Journal

ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073

Informations de publication

Date de publication:
11 Jul 2024
Historique:
pmc-release: 11 07 2025
medline: 17 7 2024
pubmed: 17 7 2024
entrez: 17 7 2024
Statut: epublish

Résumé

Substituted imidazolidinetriones (IZTs) have been identified as potent inhibitors of pyruvate carboxylase (PC) through an in silico screening approach. Alkyl 2-(2,4,5-trioxo-3-substituted imidazolidin-1-yl)acetates (

Identifiants

pubmed: 39015262
doi: 10.1021/acsmedchemlett.4c00183
pmc: PMC11247459
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1088-1093

Informations de copyright

© 2024 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Auteurs

Nicholas O Schneider (NO)

Department of Biological Science, Marquette University, P.O. Box 1881, Milwaukee, Wisconsin 53201-1881, United States.

Kendra Gilreath (K)

Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, Wisconsin 53201-1881, United States.

Niel M Henriksen (NM)

Atomwise, Inc., 250 Sutter St, Suite 650, San Francisco, California 94108, United States.

William A Donaldson (WA)

Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, Wisconsin 53201-1881, United States.

Subhabrata Chaudhury (S)

Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, Wisconsin 53201-1881, United States.

Martin St Maurice (M)

Department of Biological Science, Marquette University, P.O. Box 1881, Milwaukee, Wisconsin 53201-1881, United States.

Classifications MeSH