New Lipophilic Hydroxamates as Promising Trypanocidal Agents: Design, Synthesis, SAR, and Conformational Behavior Studies.


Journal

ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073

Informations de publication

Date de publication:
11 Jul 2024
Historique:
received: 06 03 2024
revised: 24 05 2024
accepted: 28 05 2024
medline: 17 7 2024
pubmed: 17 7 2024
entrez: 17 7 2024
Statut: epublish

Résumé

A series of novel hydroxamic acid derivatives was designed and synthesized, and their growth inhibitory activity against bloodstream form

Identifiants

pubmed: 39015276
doi: 10.1021/acsmedchemlett.4c00111
pmc: PMC11247629
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1041-1048

Informations de copyright

© 2024 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Auteurs

George Fytas (G)

Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, GR-15771 Athens, Greece.

Grigoris Zoidis (G)

Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, GR-15771 Athens, Greece.

Antonios Drakopoulos (A)

Department of Chemistry and Molecular Biology, University of Gothenburg, Göteborg SE-412 96, Sweden.

Martin C Taylor (MC)

Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.

John M Kelly (JM)

Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.

Alexandra Tsatsaroni (A)

Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, GR-15771 Athens, Greece.

Andrew Tsotinis (A)

Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, GR-15771 Athens, Greece.

Classifications MeSH