Impact of microscopic deposits of yolk sac tumor on recurrence of mature sacrococcygeal teratoma.
oncologic recurrence
sacrococcygeal teratoma
yolk sac tumor
Journal
Journal of surgical oncology
ISSN: 1096-9098
Titre abrégé: J Surg Oncol
Pays: United States
ID NLM: 0222643
Informations de publication
Date de publication:
17 Jul 2024
17 Jul 2024
Historique:
received:
20
05
2024
accepted:
25
06
2024
medline:
17
7
2024
pubmed:
17
7
2024
entrez:
17
7
2024
Statut:
aheadofprint
Résumé
Sacrococcygeal teratomas (SCT) with malignant histology frequently recur and are treated aggressively, but risk factors and surveillance protocols are less established for mature tumors. In particular, prior studies have not investigated whether microscopic deposits of yolk sac tumor (YST) in otherwise mature teratomas lead to higher recurrence rates. We reviewed patients with mature SCTs resected at our institution from 2011 to 2021 and analyzed tumor characteristics, treatment, and outcomes. We identified 56 patients with mature SCT, of which 9 (16%) demonstrated microscopic YST. Following surgery, 7/56 (13%) patients developed local recurrence at a mean of 1.2 ± 0.7 years, while no patients developed metastases. Recurrence was more likely in patients with microscopic YST [5/9 (56%) vs. 2/47 (4%), p = 0.021] and positive margins [6/24 (35%) vs. 1/32 (3.1%), p = 0.030]. A solid tumor component tended to increase recurrence risk as well [6/29 (21%) vs. 1/27 (4%), p = 0.053]. Five patients demonstrated malignant recurrence and were all detected by a rising alpha-fetoprotein (AFP), while two patients demonstrated recurrence of mature teratoma and were detected on surveillance magnetic resonance imaging (MRI). Microscopic foci of YST may increase recurrence risk for patients with mature SCT. Such patients might benefit from closer postoperative surveillance with serial AFP measurements and MRI.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 Wiley Periodicals LLC.
Références
Peter Altman R, Randolph JG, Lilly JR. Sacrococcygeal teratoma: American Academy of Pediatrics Surgical Section Survey – 1973. J Pediatr Surg. 1974;9(3):389‐398. doi:10.1016/s0022-3468(74)80297-6
Mahour GH, Woolley MM, Trivedi SN, Landing BH. Sacrococcygeal teratoma: a 33‐year experience. J Pediatr Surg. 1975;10(2):183‐188. doi:10.1016/0022-3468(75)90276-6
Forrester MB, Merz RD. Descriptive epidemiology of teratoma in infants, Hawaii, 1986‐2001. Paediatr Perinat Epidemiol. 2006;20(1):54‐58. doi:10.1111/j.1365-3016.2006.00678.x
Hambraeus M, Arnbjörnsson E, Börjesson A, Salvesen K, Hagander L. Sacrococcygeal teratoma: a population‐based study of incidence and prenatal prognostic factors. J Pediatr Surg. 2016;51(3):481‐485. doi:10.1016/j.jpedsurg.2015.09.007
Niramis R, Anuntkosol M, Buranakitjaroen V, et al. Long‐term outcomes of sacrococcygeal germ cell tumors in infancy and childhood. Surg Res Pract. 2015;2015:398549. doi:10.1155/2015/398549
Swamy R, Embleton N, Hale J. Sacrococcygeal teratoma over two decades: birth prevalence. Prenat Diagn. 2008;28(11):1048‐1051. doi:10.1002/pd.2122
Kops AL, Hulsker CC, Fiocco M, et al. Malignant recurrence after mature sacrococcygeal teratoma: a meta‐analysis and review of the literature. Crit Rev Oncol Hematol. 2020;156:103140. doi:10.1016/j.critrevonc.2020.103140
Noseworthy J, Lack EE, Kozakewich HPW, Vawter GF, Welch KJ. Sacrococcygeal germ cell tumors in childhood: an updated experience with 118 patients. J Pediatr Surg. 1981;16(3):358‐364. doi:10.1016/s0022-3468(81)80695-1
Havránek P, Rubenson A, Güth D, et al. Sacrococcygeal teratoma in Sweden: a 10‐year national retrospective study. J Pediatr Surg. 1992;27(11):1447‐1450. doi:10.1016/0022-3468(92)90197-f
Rescorla FJ, Sawin RS, Coran AG, Dillon PW, Azizkhan RG. Long‐term outcome for infants and children with sacrococcygeal teratoma: a report from the children's cancer group. J Pediatr Surg. 1998;33(2):171‐176. doi:10.1016/s0022-3468(98)90426-2
Daubenton JD, Hartley PS, Rode H, Sinclair‐Smith CC. Sacrococcygeal germ‐cell tumours—the Red Cross War Memorial Children's Hospital experience, 1980‐1996. S Afr Med J. 1998;88(12):1592‐1594.
Perrelli L, D'urzo C, Manzoni C, et al. Sacrococcygeal teratoma. Outcome and management. J Perinat Med. 2002;30(2):179‐184. doi:10.1515/JPM.2002.024
De Backer A, Madern GC, Hakvoort‐Cammel FG, Haentjens P, Oosterhuis JW, Hazebroek FW. Study of the factors associated with recurrence in children with sacrococcygeal teratoma. J Pediatr Surg. 2006;41:173‐181. doi:10.1016/j.jpedsurg.2005.10.022
Derikx JPM, De Backer A, Van de Schoot L, et al. Factors associated with recurrence and metastasis in sacrococcygeal teratoma. Br J Surg. 2006;93(12):1543‐1548. doi:10.1002/bjs.5379
Yao W, Li K, Zheng S, Dong K, Xiao X. Analysis of recurrence risks for sacrococcygeal teratoma in children. J Pediatr Surg. 2014;49:1839‐1842. doi:10.1016/j.jpedsurg.2014.09.036
Padilla BE, Vu L, Lee H, et al. Sacrococcygeal teratoma: late recurrence warrants long‐term surveillance. Pediatr Surg Int. 2017;33:1189‐1194. doi:10.1007/s00383-017-4132-1
Yoneda A, Usui N, Taguchi T, et al. Impact of the histological type on the prognosis of patients with prenatally diagnosed sacrococcygeal teratomas: the results of a nationwide Japanese survey. Pediatr Surg Int. 2013;29:1119‐1125. doi:10.1007/s00383-013-3384-7
Hager T, Sergi C, Hager J. Sacrococcygeal teratoma – a single center study of 43 years (1968–2011) including follow‐up data and histopathological reevaluation of specimens. Eur Surg. 2012;44:255‐266. doi:10.1007/s10353-012-0098-3
Yoshida M, Matsuoka K, Nakazawa A, et al. Sacrococcygeal yolk sac tumor developing after teratoma: a clinicopathological study of pediatric sacrococcygeal germ cell tumors and a proposal of the pathogenesis of sacrococcygeal yolk sac tumors. J Pediatr Surg. 2013;48:776‐781. doi:10.1016/j.jpedsurg.2012.08.028
Lo Curto M, D'Angelo P, Cecchetto G, et al. Mature and immature teratomas: results of the first paediatric Italian study. Pediatr Surg Int. 2007;23:315‐322. doi:10.1007/s00383-007-1890-1
Bilik R, Shandling B, Pope M, Thorner P, Weitzman S, Ein SH. Malignant benign neonatal sacrococcygeal teratoma. J Pediatr Surg. 1993;28(9):1158‐1160. doi:10.1016/0022-3468(93)90154-d
Hawkins E, Issacs H, Cushing B, Rogers P. Occult malignancy in neonatal sacrococcygeal teratomas: a report from a combined Pediatric Oncology Group and Children's Cancer Group study. Am J Pediatr Hematol Oncol. 1993;15(4):406‐409.
Göbel U, Calaminus G, Engert J, et al. Teratomas in infancy and childhood. Med Pediatr Oncol. 1998;31(1):8‐15. doi:10.1002/(SICI)1096-911X(199807)31:13.0.CO;2-H
Heifetz SA, Cushing B, Giller R, et al. Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children's Cancer Group. Am J Surg Pathol. 1998;22:1115‐1124. doi:10.1097/00000478-199809000-00011