Targeting the multifaceted BRAF in cancer: New directions.

Humans Proto-Oncogene Proteins B-raf / genetics Neoplasms / genetics Molecular Targeted Therapy Protein Kinase Inhibitors / pharmacology Mutation Antineoplastic Agents / pharmacology Animals MAP Kinase Signaling System / genetics
BRAF MAPK genomics pan-cancer precision oncology

Journal

Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965

Informations de publication

Date de publication:
16 Jul 2024
Historique:
medline: 17 7 2024
pubmed: 17 7 2024
entrez: 17 7 2024
Statut: epublish

Résumé

Activating mutations in the mitogen-activated protein kinase (MAPK) pathway represent driver alterations governing tumorigenesis, metastasis, and therapy resistance. MAPK activation predominantly occurs through genomic alterations in

Identifiants

DOI: 10.18632/oncotarget.28612 PMID: 39018217
pubmed: 39018217
pii: 28612
doi: 10.18632/oncotarget.28612
doi:

Substances chimiques

Proto-Oncogene Proteins B-raf EC 2.7.11.1
Protein Kinase Inhibitors 0
BRAF protein, human EC 2.7.11.1
Antineoplastic Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

486-492

Auteurs

Eamon Toye (E)

Masonic Cancer Center, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
Department of Medicine, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA.

Alexander Chehrazi-Raffle (A)

City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.

Justin Hwang (J)

Masonic Cancer Center, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
Department of Medicine, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.

Emmanuel S Antonarakis (ES)

Masonic Cancer Center, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
Department of Medicine, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeting the multifaceted BRAF in cancer: New...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinases raf › Protéines proto-oncogènes B-raf › Targeting the multifaceted BRAF in cancer: New...
questionsmedicales.fr › Tumeurs › Targeting the multifaceted BRAF in cancer: New...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Targeting the multifaceted BRAF in cancer: New...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Targeting the multifaceted BRAF in cancer: New...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Targeting the multifaceted BRAF in cancer: New...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Targeting the multifaceted BRAF in cancer: New...
questionsmedicales.fr › Eucaryotes › Animaux › Targeting the multifaceted BRAF in cancer: New...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › Targeting the multifaceted BRAF in cancer: New...