Performance and safety of the PRICO closed-loop oxygen saturation targeting system in neonates: pragmatic multicentre cross-over study (TarOx Study).

This study aims to evaluate the performance of the fabian-Predictive-Intelligent-Control-of-Oxygenation (PRICO) system for automated control of the fraction of inspired oxygen (FiO Multicentre randomised cross-over study. Five neonatal intensive care units experienced with automated control of FiO 39 infants: median gestational age of 27 weeks (IQR: 26-30), postnatal age 7 days (IQR: 2-17), weight 1120 g (IQR: 915-1588), FiO Randomised sequential 24-hour periods of automated and manual FiO Proportion (%) of time in normoxaemia (90%-95% with FiO During automated control, subjects spent more time in normoxaemia (74%±22% vs 51%±22%, p<0.001) with less time above and below (<90% (9%±8% vs 12%±11%, p<0.001) and >95% with FiO This study demonstrates the ability of the PRICO automated oxygen control algorithm to improve the maintenance of SpO

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Déclaration de conflit d'intérêts

Competing interests: All the authors or their institutions received funding for this and additional projects from Vyaire Medical.