Fas (CD95) expression in adipocytes contributes to diet-induced obesity.

Journal

Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860

Informations de publication

Date de publication:
17 Jul 2024
Historique:
revised: 02 05 2024
received: 09 02 2024
accepted: 05 05 2024
medline: 18 7 2024
pubmed: 18 7 2024
entrez: 18 7 2024
Statut: aheadofprint

Résumé

Induction of browning in white adipose tissue (WAT) increases energy expenditure and may be an attractive target for the treatment of obesity. Since activation of Fas (CD95) induces pathways known to blunt expression of uncoupling protein 1 (UCP1), we hypothesized that Fas expression in adipocytes inhibits WAT browning and thus contributes to the development of obesity. Adipocyte-specific Fas knockout (Fas HFD-fed Fas Fas activation in adipocytes contributes to HFD-associated adiposity in rodents and may be a therapeutic target to reduce obesity and associated diseases.

Identifiants

DOI: 10.1002/oby.24092 PMID: 39020501
pubmed: 39020501
doi: 10.1002/oby.24092
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Swiss National Science Foundation
ID : 310030-179344
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 310030-215451
Pays : Switzerland
Organisme : Maastricht University
Organisme : University of Birmingham
Organisme : Deutsche Forschungsgemeinschaft
ID : 209933838

Informations de copyright

© 2024 The Author(s). Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.

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Auteurs

Stephan Wueest (S)

Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, University of Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0002-0176-8906

Chiara Scaffidi (C)

Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, University of Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Pim P van Krieken (PP)

Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, University of Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Nils K Konrad (NK)

Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, University of Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.
Department of Medical Oncology and Hematology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

Christian Koch (C)

Department of Medical Oncology and Hematology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

Michael S F Wiedemann (MSF)

Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, University of Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Anne Goergen (A)

Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, University of Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Marcela Borsigova (M)

Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, University of Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Ioannis G Lempesis (IG)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.

Jonas Fullin (J)

Department of Medical Oncology and Hematology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

Konstantinos N Manolopoulos (KN)

Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.

Steffen Böttcher (S)

Department of Medical Oncology and Hematology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

Gijs H Goossens (GH)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
ORCID: 0000-0002-2092-3019

Matthias Blüher (M)

Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.

Daniel Konrad (D)

Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, University of Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.
Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0001-9067-4356

Classifications MeSH