Peptide and Peptidomimetic Inhibitors Targeting the Interaction of Collapsin Response Mediator Protein 2 with the N-Type Calcium Channel for Pain Relief.
Journal
ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411
Informations de publication
Date de publication:
12 Jul 2024
12 Jul 2024
Historique:
received:
28
03
2024
revised:
13
05
2024
accepted:
23
05
2024
pmc-release:
06
06
2025
medline:
18
7
2024
pubmed:
18
7
2024
entrez:
18
7
2024
Statut:
epublish
Résumé
Ion channels serve pleiotropic functions. Often found in complexes, their activities and functions are sculpted by auxiliary proteins. We discovered that collapsin response mediator protein 2 (CRMP2) is a binding partner and regulator of the N-type voltage-gated calcium channel (Ca
Identifiants
pubmed: 39022365
doi: 10.1021/acsptsci.4c00181
pmc: PMC11249630
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1916-1936Informations de copyright
© 2024 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): R. Khanna is a co-founder of Regulonix LLC, a company developing non-opioid drugs for chronic pain.