Basaloid squamous cell carcinoma in the mandibular alveolus: A rare case report with differential diagnosis.
Journal
Journal of cancer research and therapeutics
ISSN: 1998-4138
Titre abrégé: J Cancer Res Ther
Pays: India
ID NLM: 101249598
Informations de publication
Date de publication:
01 Apr 2024
01 Apr 2024
Historique:
received:
08
10
2022
accepted:
11
11
2022
medline:
18
7
2024
pubmed:
18
7
2024
entrez:
18
7
2024
Statut:
ppublish
Résumé
Basaloid squamous cell carcinoma (BSCC) is a distinct, high-grade variant of oral squamous cell carcinoma (OSCC) with a poor prognosis. In the head and neck region, the most common sites are the epiglottis, piriform sinus, and tongue base. Other less common sites include the floor of the mouth, oral mucosa, palate, tonsils, nasopharynx, and trachea. In the present report, the unusual case of a 69-year-old male is presented; the patient exhibited ulceroproliferative growth involving the lower alveolus. Incisional biopsy was done and the hematoxylin and eosin-stained sections revealed tumor islands with dysplastic oral epithelial cells invading the underlying connective tissue as islands, cords, and nests. The presence of palisading basaloid cells with a central area of comedo necrosis and keratin formation on the islands revealed the diagnosis of BSCC. Immunohistochemistry demonstrated positive staining for proliferative cell nuclear antigen (PCNA) and pan-cytokeratin. The patient is still under treatment and follow-up.
Identifiants
pubmed: 39023624
doi: 10.4103/jcrt.jcrt_2091_22
pii: 01363817-202420030-00064
doi:
Types de publication
Case Reports
Letter
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1092-1096Informations de copyright
Copyright © 2023 Copyright: © 2023 Journal of Cancer Research and Therapeutics.
Références
Pathak J, Swain N, Patel S, Poonja L. Histopathological variants of oral squamous cell carcinoma-institutional case reports. J Oral Maxillofac Pathol 2014;18:143–5.
Wain SL, Kier R, Vollmer RT, Bossen EH. Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx:Report of 10 cases. Hum Pathol 1986;17:1158–66.
Protyusha G B, Sivapathasundharam B. Basaloid squamous cell carcinoma in the maxillary gingiva. J Can Res Ther 2021;17:1108–11.
Paulino AF, Singh B, Shah JP, Huvos AG. Basaloid squamous cell carcinoma of the head and neck. Laryngoscope 2000;110:1479–82.
Sánchez M, Benegas M, Vollmer I. Management of incidental lung nodules<8 mm in diameter. J Thorac Dis 2018;10:2611–27.
Thompson LD. Squamous cell carcinoma variants of the head and neck. Curr Diagn Pathol 2003;9:384–96.
Barnes L, MacMillan C, Ferlito A, Rinaldo A, Altavilla G, Doglioni C. Basaloid squamous cell carcinoma of the head and neck:Clinicopathological features and differential diagnosis. Ann Otol Rhinol Laryngol 1996;105:75–82.
Emanuel P, Wang B, Wu M, Burstein DE. p63 immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Mod Pathol 2005;18:645–50.
Yu GY, Gao Y, Peng X, Chen Y, Zhao F-Y, Wu M-J. A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region. Int J Oral Maxillofac Surg 2008;37:1003–8.
Wieneke JA, Thompson LD, Wenig BM. Basaloid squamous cell carcinoma of the sinonasal tract. Cancer 1999;85:841–54.
Chakravarthi S, Karikalan B. Basaloid squamous cell carcinoma of the oropharynx-brief overview. Int J Pharm Res 2020;12:438–42.