Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention.
Journal
npj aging
ISSN: 2731-6068
Titre abrégé: NPJ Aging
Pays: England
ID NLM: 9918402285106676
Informations de publication
Date de publication:
18 Jul 2024
18 Jul 2024
Historique:
received:
16
01
2024
accepted:
24
06
2024
medline:
19
7
2024
pubmed:
19
7
2024
entrez:
18
7
2024
Statut:
epublish
Résumé
Inflammageing leads to uncontrolled leukocyte trafficking in response to inflammatory insults. Here, we used a zymosan-induced peritonitis mouse model on inflammation to investigate the role of the PEPITEM pathway on leukocyte migration in ageing. We then analysed whether PEPITEM could modulate leukocyte migration in older adults. We observed a loss of functionality in the PEPITEM pathway, which normally controls leukocyte trafficking in response to inflammation, in older adults and aged mice and show that this can be rescued by supplementation with PEPITEM. Thus, leading to the exciting possibility that PEPITEM supplementation may represent a potential pre-habilitation geroprotective agent to rejuvenate immune functions.
Identifiants
pubmed: 39025913
doi: 10.1038/s41514-024-00160-6
pii: 10.1038/s41514-024-00160-6
doi:
Types de publication
Journal Article
Langues
eng
Pagination
33Subventions
Organisme : University of Birmingham
ID : BHAM FELLOWSHIP
Organisme : British Heart Foundation (BHF)
ID : FS/20/2/34799
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/T028025/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/P016154/1
Organisme : Royal Society
ID : RGF\R1\180008
Organisme : Royal Society
ID : DH16044
Organisme : Rosetrees Trust
ID : A2092
Informations de copyright
© 2024. The Author(s).
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