Application of untargeted liquid chromatography-mass spectrometry to routine analysis of food using three-dimensional bucketing and machine learning.
Food profiling
Honey
Machine learning
Mass spectrometry
Routine analysis
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 Jul 2024
18 Jul 2024
Historique:
received:
27
11
2023
accepted:
11
07
2024
medline:
19
7
2024
pubmed:
19
7
2024
entrez:
18
7
2024
Statut:
epublish
Résumé
For the detection of food adulteration, sensitive and reproducible analytical methods are required. Liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) is a highly sensitive method that can be used to obtain analytical fingerprints consisting of a variety of different components. Since the comparability of measurements carried out with different devices and at different times is not given, specific adulterants are usually detected in targeted analyses instead of analyzing the entire fingerprint. However, this comprehensive analysis is desirable in order to stay ahead in the race against food fraudsters, who are constantly adapting their adulterations to the latest state of the art in analytics. We have developed and optimized an approach that enables the separate processing of untargeted LC‑HRMS data obtained from different devices and at different times. We demonstrate this by the successful determination of the geographical origin of honey samples using a random forest model. We then show that this approach can be applied to develop a continuously learning classification model and our final model, based on data from 835 samples, achieves a classification accuracy of 94% for 126 test samples from 6 different countries.
Identifiants
pubmed: 39026016
doi: 10.1038/s41598-024-67459-y
pii: 10.1038/s41598-024-67459-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
16594Informations de copyright
© 2024. The Author(s).
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