Precision imaging of cardiac function and scar size in acute and chronic porcine myocardial infarction using ultrahigh-field MRI.
Journal
Communications medicine
ISSN: 2730-664X
Titre abrégé: Commun Med (Lond)
Pays: England
ID NLM: 9918250414506676
Informations de publication
Date de publication:
18 Jul 2024
18 Jul 2024
Historique:
received:
25
11
2022
accepted:
24
06
2024
medline:
19
7
2024
pubmed:
19
7
2024
entrez:
18
7
2024
Statut:
epublish
Résumé
7 T cardiac magnetic resonance imaging (MRI) studies may enable higher precision in clinical metrics like cardiac function, ventricular mass, and more. Higher precision may allow early detection of functional impairment and early evaluation of treatment responses in clinical practice and pre-clinical studies. Seven female German Landrace pigs were scanned prior to and at three time points (3-4 days, 7-10 days, and ~60 days) post myocardial infarction using a whole body 7 T system and three radiofrequency (RF) coils developed and built in-house to accompany animal growth. The combination of dedicated RF hardware and 7 T MRI enables a longitudinal study in a pig model of acute and chronic infarction, providing consistent blood tissue contrast and high signal-to-noise ratio (SNR) in measurements of cardiac function, as well as low coefficients of variation (CoV) for ejection fraction (CoV Best results are achieved via manual segmentation. We define state-of-the-art procedures for large animal studies at 7 T. In magnetic resonance imaging (MRI), scanners use magnets to generate detailed images of structures in the body, such as the heart. Stronger magnets can produce stronger magnetic fields, which can be leveraged for better image quality and developing new methods for disease diagnosis. In clinical practice, such systems using strong magnets are not yet used for imaging of the heart and some safety aspects remain challenging. We apply such an imaging approach in pigs, in which heart structure and function are similar to humans. We focus on the most important clinical imaging aspects following a heart attack, namely heart function and scar detection. We demonstrate that the high magnetic strength system enabled consistent image quality and accuracy. These findings may help to guide future developments in MRI of the heart, for example in patients who have had a heart attack.
Sections du résumé
BACKGROUND
BACKGROUND
7 T cardiac magnetic resonance imaging (MRI) studies may enable higher precision in clinical metrics like cardiac function, ventricular mass, and more. Higher precision may allow early detection of functional impairment and early evaluation of treatment responses in clinical practice and pre-clinical studies.
METHODS
METHODS
Seven female German Landrace pigs were scanned prior to and at three time points (3-4 days, 7-10 days, and ~60 days) post myocardial infarction using a whole body 7 T system and three radiofrequency (RF) coils developed and built in-house to accompany animal growth.
RESULTS
RESULTS
The combination of dedicated RF hardware and 7 T MRI enables a longitudinal study in a pig model of acute and chronic infarction, providing consistent blood tissue contrast and high signal-to-noise ratio (SNR) in measurements of cardiac function, as well as low coefficients of variation (CoV) for ejection fraction (CoV
CONCLUSIONS
CONCLUSIONS
Best results are achieved via manual segmentation. We define state-of-the-art procedures for large animal studies at 7 T.
In magnetic resonance imaging (MRI), scanners use magnets to generate detailed images of structures in the body, such as the heart. Stronger magnets can produce stronger magnetic fields, which can be leveraged for better image quality and developing new methods for disease diagnosis. In clinical practice, such systems using strong magnets are not yet used for imaging of the heart and some safety aspects remain challenging. We apply such an imaging approach in pigs, in which heart structure and function are similar to humans. We focus on the most important clinical imaging aspects following a heart attack, namely heart function and scar detection. We demonstrate that the high magnetic strength system enabled consistent image quality and accuracy. These findings may help to guide future developments in MRI of the heart, for example in patients who have had a heart attack.
Autres résumés
Type: plain-language-summary
(eng)
In magnetic resonance imaging (MRI), scanners use magnets to generate detailed images of structures in the body, such as the heart. Stronger magnets can produce stronger magnetic fields, which can be leveraged for better image quality and developing new methods for disease diagnosis. In clinical practice, such systems using strong magnets are not yet used for imaging of the heart and some safety aspects remain challenging. We apply such an imaging approach in pigs, in which heart structure and function are similar to humans. We focus on the most important clinical imaging aspects following a heart attack, namely heart function and scar detection. We demonstrate that the high magnetic strength system enabled consistent image quality and accuracy. These findings may help to guide future developments in MRI of the heart, for example in patients who have had a heart attack.
Identifiants
pubmed: 39026075
doi: 10.1038/s43856-024-00559-y
pii: 10.1038/s43856-024-00559-y
doi:
Types de publication
Journal Article
Langues
eng
Pagination
146Informations de copyright
© 2024. The Author(s).
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