Is it safe to implant a penile prosthesis in a solid organ transplant recipient? A systematic review.
Journal
International journal of impotence research
ISSN: 1476-5489
Titre abrégé: Int J Impot Res
Pays: England
ID NLM: 9007383
Informations de publication
Date de publication:
18 Jul 2024
18 Jul 2024
Historique:
received:
11
03
2024
accepted:
14
06
2024
revised:
09
06
2024
medline:
19
7
2024
pubmed:
19
7
2024
entrez:
18
7
2024
Statut:
aheadofprint
Résumé
Solid organ transplant recipients exhibit an elevated incidence of erectile dysfunction, attributed to comorbidities and specific factors associated with organ failure. While treatment mirrors the general population's, response rates are lower, and there is a heightened concern about implanting a penile prosthesis in immunocompromised patients due to the potential occurrence of severe complications. The aim of this study was to assess the safety of penile prostheses in this population. Among fourteen included studies, ten were case reports or series of cases, and four were non randomized case-control studies with non-transplanted patients as controls. Complications affected 34 patients (11.15%), with mechanical device failures in 18 cases (5.9%) and infections in 13 cases (4.26%). Most infections required hospitalization, antibiotic treatment, and prosthesis removal, with two cases of life-threatening Fournier's gangrene. Case-control studies revealed no differences in overall reoperation rates between transplant recipients and controls. However, pelvic organ transplant recipients undergoing three-piece prosthesis implantation showed higher complications rates related to reservoir issues. Despite limited evidence, case-control studies demonstrated a generally low/moderate risk of bias within each specific domain, although overall bias was moderate/severe. As a result, clinicians may mitigate concerns regarding penile prosthesis implantation in solid organ transplant recipients.
Identifiants
pubmed: 39026089
doi: 10.1038/s41443-024-00939-x
pii: 10.1038/s41443-024-00939-x
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Thomas Prudhomme
(T)
Alicia López Abad
(AL)
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature Limited.
Références
Kugler C, Gottlieb J, Warnecke G, Schwarz A, Weissenborn K, Barg-Hock H, et al. Health-related quality of life after solid organ transplantation: a prospective, multiorgan cohort study. Transplantation. 2013;96:316–23.
doi: 10.1097/TP.0b013e31829853eb
pubmed: 23715048
Thirumavalavan N, Wilken N, Ramasamy R. Hypogonadism and renal failure: an update. Indian J Urol. 2015;31:89.
doi: 10.4103/0970-1591.154297
pubmed: 25878406
pmcid: 4397561
Thirumavalavan N, Scovell JM, Link RE, Lamb DJ, Lipshultz LI. Does solid organ transplantation affect male reproduction? Eur Urol Focus. 2018;4:307–10.
doi: 10.1016/j.euf.2018.08.012
pubmed: 30194032
pmcid: 6204091
Payne K, Popat S, Lipshultz LI, Thirumavalavan N. The prevalence and treatment of erectile dysfunction in male solid organ transplant recipients. Sex Med Rev. 2021;9:331–9.
doi: 10.1016/j.sxmr.2019.10.002
pubmed: 31859242
Rosen RC, Fisher WA, Eardley I, Niederberger C, Nadel A, Sand M. The multinational Men’s Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin. 2004;20:607–17.
doi: 10.1185/030079904125003467
pubmed: 15171225
Sharma RK, Prasad N, Gupta A, Kapoor R. Treatment of erectile dysfunction with sildenafil citrate in renal allograft recipients: a randomized, double-blind, placebo-controlled, crossover trial. Am J Kidney Dis. 2006;48:128–33.
doi: 10.1053/j.ajkd.2006.04.061
pubmed: 16797395
Demir E, Balal M, Paydas S, Sertdemir Y, Erken U. Efficacy and safety of vardenafil in renal transplant recipients with erectile dysfunction. Transplant Proc. 2006;38:1379–81.
doi: 10.1016/j.transproceed.2006.02.076
pubmed: 16797309
Lasaponara F, Paradiso M, Milan MGL, Morabito F, Sedigh O, Graziano ME, et al. Erectile dysfunction after kidney transplantation: our 22 years of experience. Transplant Proc. 2004;36:502–4.
doi: 10.1016/j.transproceed.2004.02.014
pubmed: 15110572
Livi U, Faggian G, Sorbara C, Gambino A, Calabrò A, Artibani W, et al. Use of prostaglandin E1 in the treatment of sexual impotence after heart transplantation: initial clinical experience. J Heart Lung Transplant Off Publ Int Soc Heart Transplant. 1993;12:484–6.
Mansi MK, Alkhudair WK, Huraib S. Treatment of erectile dysfunction after kidney transplantation with intracavernosal self-injection of prostaglandin E1. J Urol. 1998;159:1927–30.
doi: 10.1016/S0022-5347(01)63198-7
pubmed: 9598489
Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, et al. EAU working group on male sexual and reproductive health. european association of urology guidelines on Sexual and Reproductive Health-2021 update: male sexual dysfunction. Eur Urol. 2021;8:333–57.
doi: 10.1016/j.eururo.2021.06.007
Erikoglu M, Tavli S, Turk S. Fournier’s gangrene after renal transplantation. Nephrol Dial Transplant. 2005;20:449–50.
doi: 10.1093/ndt/gfh624
pubmed: 15673697
Walther PJ, Andriani RT, Maggio MI, Carson CC. Fournier’s gangrene: a complication of penile prosthetic implantation in a renal transplant patient. J Urol. 1987;137:299–300.
doi: 10.1016/S0022-5347(17)43987-5
pubmed: 3543410
Sun AY, Babbar P, Gill BC, Angermeier KW, Montague DK. Penile prosthesis in solid organ transplant recipients—a matched cohort study. Urology. 2018;117:86–8.
doi: 10.1016/j.urology.2018.03.048
pubmed: 29656065
Knoll T, Omar MI, Maclennan S, Hernández V, Canfield S, Yuan Y, et al. Key steps in conducting systematic reviews for underpinning clinical practice guidelines: methodology of the European Association of Urology. Eur Urol. 2018;73:290–300.
doi: 10.1016/j.eururo.2017.08.016
pubmed: 28917594
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
Greenberg JW, Dick BP, Hellstrom WJG, Paramesh A, Raheem O. Safety of penile prosthesis surgery in solid organ transplant patients. Int J Impot Res. 2022;34:507–8.
doi: 10.1038/s41443-021-00499-4
pubmed: 34799714
Gaffney CD, Fainberg J, Punjani N, Aboukhshaba A, Pierce H, Patel N, et al. Immune deficiency does not increase inflatable penile prosthesis reoperation rates. J Sex Med. 2021;18:1427–33.
doi: 10.1016/j.jsxm.2021.06.005
pubmed: 34303632
Cuellar DC, Sklar GN. Penile prosthesis in the organ transplant recipient. Urology. 2001;57:138–41.
doi: 10.1016/S0090-4295(00)00876-1
pubmed: 11164159
Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919.
Sausville J, Gupta G, Forrest G, Chai T. Salmonella infection of a penile prosthesis. J Sex Med. 2009;6:1487–90.
doi: 10.1111/j.1743-6109.2008.01013.x
pubmed: 18823319
Pavone C, Abbadessa D, Leto G, Giaimo RM, Ascoli R, Usala M, et al. Penile flexiflate
doi: 10.5301/RU.2011.6446
Kabalin JN, Kessler R. Successful implantation of penile prostheses in organ transplant patients. Urology. 1989;33:282–4.
doi: 10.1016/0090-4295(89)90265-3
pubmed: 2648658
Sidi AA, Peng W, Sanseau C, Lange PH. Penile prosthesis surgery in the treatment of impotence in the immunosuppressed man. J Urol. 1987;137:681–2.
doi: 10.1016/S0022-5347(17)44173-5
pubmed: 3560322
Pearson TC, Futral AA, Routenberg KL, Oʼbrien DP, Whelchel JD, Neylan JF, et al. Delayed urinary bladder leak after combined kidney-pancreas transplantation association with penile prosthesis implantation. Transplantation. 1995;60:624.
doi: 10.1097/00007890-199509270-00021
pubmed: 7570965
Rowe SJ, Montague DK, Steinmuller DR, Lakin MM, Novick AC. Treatment of organic impotence with penile prosthesis in renal transplant patients. Urology. 1993;41:16–20.
doi: 10.1016/0090-4295(93)90235-3
pubmed: 8420073
Govier FE, Gibbons RP, Correa RJ, Pritchett TR, Kramer-Levien D. Mechanical reliability, surgical complications, and patient and partner satisfaction of the modern three-piece inflatable penile prosthesis. Urology. 1998;52:282–6.
doi: 10.1016/S0090-4295(98)00177-0
pubmed: 9697795
Timsit JF, Sonneville R, Kalil AC, Bassetti M, Ferrer R, Jaber S, et al. Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients. Intensive Care Med. 2019;45:573–91.
doi: 10.1007/s00134-019-05597-y
pubmed: 30911807
pmcid: 7079836
Natali A, Olianas R, Fisch M. Penile implantation in Europe: successes and complications with 253 implants in Italy and Germany. J Sex Med. 2008;5:1503–12.
doi: 10.1111/j.1743-6109.2008.00819.x
pubmed: 18410306
Gon LM, De Campos CCC, Voris BRI, Passeri LA, Fregonesi A, Riccetto CLZ. A systematic review of penile prosthesis infection and meta-analysis of diabetes mellitus role. BMC Urol. 2021;21:35.
doi: 10.1186/s12894-020-00730-2
pubmed: 33691670
pmcid: 7945372
Mandava SH, Serefoglu EC, Freier MT, Wilson SK, Hellstrom WJG. Infection retardant coated inflatable penile prostheses decrease the incidence of infection: a systematic review and meta-analysis. J Urol. 2012;188:1855–60.
doi: 10.1016/j.juro.2012.07.022
pubmed: 22999690
Wilson SK, Gross MS. Biofilm and penile prosthesis infections in the era of coated implants: 2021 update. Int J Impot Res. 2022;34:411–5.
doi: 10.1038/s41443-021-00423-w
pubmed: 33714988
Hebert KJ, Kohler TS. Penile prosthesis infection: myths and realities. World J Mens Health. 2019;37:276.
doi: 10.5534/wjmh.180123
pubmed: 30929326
pmcid: 6704299
Onyeji IC, Sui W, Pagano MJ, Weinberg AC, James MB, Theofanides MC, et al. Impact of surgeon case volume on reoperation rates after inflatable penile prosthesis surgery. J Urol. 2017;197:223–9.
doi: 10.1016/j.juro.2016.08.083
pubmed: 27545573
Topuz B, Ebiloğlu T, Zor M, Kaya E, Sarıkaya S, Emrah Coğuplugil A, et al. Penile prosthesis implantation: a single center 25 years of experience. Prog En Urol. 2021;31:663–70.
doi: 10.1016/j.purol.2021.06.002
Palmisano F, Boeri L, Cristini C, Antonini G, Spinelli MG, Franco G, et al. Comparison of infra pubic vs. penoscrotal approaches for 3-piece inflatable penile prosthesis placement: do we have a winner? Sex Med Rev. 2018;6:631–9.
doi: 10.1016/j.sxmr.2018.03.007
pubmed: 29730314