Ellagic acid-modified gold nanoparticles to combat multi-drug resistant bacterial infections

Journal

Materials horizons
ISSN: 2051-6355
Titre abrégé: Mater Horiz
Pays: England
ID NLM: 101623537

Informations de publication

Date de publication:
19 Jul 2024
Historique:
medline: 19 7 2024
pubmed: 19 7 2024
entrez: 19 7 2024
Statut: aheadofprint

Résumé

The overuse of antibiotics has led to the rapid development of multi-drug resistant bacteria, making antibiotics increasingly ineffective against bacterial infections. Consequently, there is an urgent need to develop alternative strategies to combat multi-drug-resistant bacterial infections. In this study, gold nanoparticles modified with ellagic acid (EA-AuNPs) were prepared using a simple and mild one-pot hydrothermal process. EA-AuNPs demonstrated high bactericidal efficacy and broad-spectrum antimicrobial activities against clinical isolates of the antibiotic-resistant ESKAPE pathogens. Furthermore, EA-AuNPs effectively disperse biofilms of multi-drug-resistant bacteria. Additionally, EA-AuNPs mitigated inflammatory responses at the bacterial infection sites. The combined bactericidal and anti-inflammatory treatment with EA-AuNPs resulted in faster curing of peritonitis caused by

Identifiants

DOI: 10.1039/d4mh00642a PMID: 39026466
pubmed: 39026466
doi: 10.1039/d4mh00642a
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Yaran Wang (Y)

Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. yuanfengli@wmu.edu.cn.
University of Groningen and University Medical Center Groningen, Department of Biomaterials & Biomedical Technology, Groningen, The Netherlands. h.c.van.der.mei@umcg.nl.
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China. shilinqi@nankai.edu.cn.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China. y.liu@ucas.ac.cn.

Fan Wu (F)

Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. yuanfengli@wmu.edu.cn.
University of Groningen and University Medical Center Groningen, Department of Biomaterials & Biomedical Technology, Groningen, The Netherlands. h.c.van.der.mei@umcg.nl.
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China. shilinqi@nankai.edu.cn.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China. y.liu@ucas.ac.cn.

Yuanfeng Li (Y)

Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. yuanfengli@wmu.edu.cn.

Siran Wang (S)

Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. yuanfengli@wmu.edu.cn.
University of Groningen and University Medical Center Groningen, Department of Biomaterials & Biomedical Technology, Groningen, The Netherlands. h.c.van.der.mei@umcg.nl.
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China. shilinqi@nankai.edu.cn.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China. y.liu@ucas.ac.cn.

Yijin Ren (Y)

University of Groningen and University Medical Center Groningen, Department of Orthodontics, Groningen, The Netherlands.

Linqi Shi (L)

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China. shilinqi@nankai.edu.cn.
ORCID: 0000-0002-9534-795X

Henny C van der Mei (HC)

University of Groningen and University Medical Center Groningen, Department of Biomaterials & Biomedical Technology, Groningen, The Netherlands. h.c.van.der.mei@umcg.nl.

Yong Liu (Y)

Translational Medicine Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. yuanfengli@wmu.edu.cn.
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China. shilinqi@nankai.edu.cn.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China. y.liu@ucas.ac.cn.
ORCID: 0000-0003-1738-7857

Classifications MeSH