Insulin receptor at the blood-brain barrier: Transport and signaling.
Blood–brain barrier
Brain microvascular endothelial cells
Drug delivery
Insulin receptor
Receptor-mediated transcytosis
Regulation
Signaling
Journal
Vitamins and hormones
ISSN: 0083-6729
Titre abrégé: Vitam Horm
Pays: United States
ID NLM: 0413601
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
20
7
2024
pubmed:
20
7
2024
entrez:
19
7
2024
Statut:
ppublish
Résumé
The blood-brain barrier (BBB) is a unique system of the brain microvasculature that limits the exchange between the blood and the brain. Brain microvascular endothelial cells form the BBB as part of the neurovascular unit and express insulin receptors. The insulin receptor at the BBB has been studied in two different functional aspects. These functions include (1) the supplying of blood insulin to the brain and (2) the modulation of BBB function via insulin signaling. The first function involves drug delivery to the brain, while the second function is related to the association between central nervous system diseases and type 2 diabetes through insulin resistance. This chapter summarizes recent progress in research on the function of insulin receptors at the BBB.
Identifiants
pubmed: 39029970
pii: S0083-6729(24)00031-1
doi: 10.1016/bs.vh.2024.05.001
pii:
doi:
Substances chimiques
Receptor, Insulin
EC 2.7.10.1
Insulin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113-124Informations de copyright
Copyright © 2024. Published by Elsevier Inc.