Insulin and the blood-brain barrier.

Blood-Brain Barrier / metabolism Humans Insulin / metabolism Animals Receptor, Insulin / metabolism Biological Transport / physiology Signal Transduction / physiology Endothelial Cells / metabolism Brain / metabolism
Blood–brain barrier Insulin Insulin receptor Signaling Transport

Journal

Vitamins and hormones
ISSN: 0083-6729
Titre abrégé: Vitam Horm
Pays: United States
ID NLM: 0413601

Informations de publication

Date de publication:
2024
Historique:
medline: 20 7 2024
pubmed: 20 7 2024
entrez: 19 7 2024
Statut: ppublish

Résumé

The blood-brain barrier (BBB) predominantly regulates insulin transport into and levels within the brain. The BBB is also an important site of insulin binding and mediator of insulin receptor (INSR) signaling. The insulin transporter is separate from the INSR, highlighting the important, unique role of each protein in this structure. After a brief introduction on the structure of insulin and the INSR, we discuss the importance of insulin interactions at the BBB, the properties of the insulin transporter and the role of the BBB insulin transporter in various physiological conditions. We go on to further describe insulin BBB signaling and the impact not only within brain endothelial cells but also the cascade into other cell types within the brain. We close with future considerations to advance our knowledge about the importance of insulin at the BBB.

Identifiants

DOI: 10.1016/bs.vh.2024.02.002 PMID: 39029972
pubmed: 39029972
pii: S0083-6729(24)00005-0
doi: 10.1016/bs.vh.2024.02.002
pii:
doi:

Substances chimiques

Insulin 0
Receptor, Insulin EC 2.7.10.1

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

169-190

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Elizabeth M Rhea (EM)

Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States. Electronic address: meredime@uw.edu.

William A Banks (WA)

Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Insulin and the blood-brain barrier.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Insulin and the blood-brain barrier.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Insulin and the blood-brain barrier.
questionsmedicales.fr › Eucaryotes › Animaux › Insulin and the blood-brain barrier.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone pancréatique › Récepteur à l'insuline › Insulin and the blood-brain barrier.
questionsmedicales.fr › Métabolisme › Transport biologique › Insulin and the blood-brain barrier.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Insulin and the blood-brain barrier.
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Insulin and the blood-brain barrier.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Insulin and the blood-brain barrier.