High altitudes and partial pressure of arterial oxygen in patients with chronic obstructive pulmonary disease - A systematic review and meta-analysis.

Prior study in healthy subjects has shown a reduction of partial pressure of arterial oxygen (PaO To provide an effect size estimate for the decline in PaO A systematic search of PubMed and Embase was performed from inception to May 30, 2023. Peer-reviewed and prospective studies in patients with COPD staying at altitudes >1500 m providing arterial blood gases within the first 3 days at the target altitude. Aggregate data (AD) on study characteristics were extracted, and individual patient data (IPD) were requested. Estimates were pooled using random-effects meta-analysis. Relative risk estimates and 95 % confidence intervals for the association between PaO Thirteen studies were included in the AD analysis, of which 6 studies (222 patients, 45.2 % female) provided IPD, thus were included in the quantitative analysis. The estimated effect size of PaO This meta-analysis, providing altitude-related decrease in PaO

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Conflicts of interest The authors declare no conflict of interest concerning this work.