IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer.
Animals
Colorectal Neoplasms
/ pathology
Humans
Tumor Microenvironment
/ immunology
Neuroglia
/ metabolism
Signal Transduction
Mice
Macrophages
/ metabolism
Receptors, Interleukin-1
/ metabolism
Tumor-Associated Macrophages
/ immunology
Interleukin-6
/ metabolism
Monocytes
/ metabolism
Mice, Inbred C57BL
Cell Communication
Cell Differentiation
Cell Line, Tumor
Female
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 Jul 2024
19 Jul 2024
Historique:
received:
16
09
2023
accepted:
11
07
2024
medline:
20
7
2024
pubmed:
20
7
2024
entrez:
19
7
2024
Statut:
epublish
Résumé
Enteric glia have been recently recognized as key components of the colonic tumor microenvironment indicating their potential role in colorectal cancer pathogenesis. Although enteric glia modulate immune responses in other intestinal diseases, their interaction with the colorectal cancer immune cell compartment remains unclear. Through a combination of single-cell and bulk RNA-sequencing, both in murine models and patients, here we find that enteric glia acquire an immunomodulatory phenotype by bi-directional communication with tumor-infiltrating monocytes. The latter direct a reactive enteric glial cell phenotypic and functional switch via glial IL-1R signaling. In turn, tumor glia promote monocyte differentiation towards pro-tumorigenic SPP1
Identifiants
pubmed: 39030280
doi: 10.1038/s41467-024-50438-2
pii: 10.1038/s41467-024-50438-2
doi:
Substances chimiques
Receptors, Interleukin-1
0
Interleukin-6
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6079Subventions
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : G0D8317N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : G0A7919N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : G086721N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : G088816N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : S008419N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : G067821N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : 11L0822N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : G067821N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : 1S44123N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : G0B4620N
Organisme : KU Leuven (Katholieke Universiteit Leuven)
ID : C12/15/016
Organisme : KU Leuven (Katholieke Universiteit Leuven)
ID : C14/17/097
Organisme : KU Leuven (Katholieke Universiteit Leuven)
ID : C3 grant, C3/21/037 or C3/23/067
Organisme : Stichting Tegen Kanker (Belgian Foundation Against Cancer)
ID : F/2020/1512
Organisme : Stichting Tegen Kanker (Belgian Foundation Against Cancer)
ID : F/2020/1512
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions)
ID : 79756-GLIAMAC
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 833816-NEUMACS
Informations de copyright
© 2024. The Author(s).
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