Correlation between the number of interstitial neurons of the white matter and number of neurons within cortical layers: Histological analyses in postnatal macaque.
NeuN‐labeled cells
QuPath: Open‐source software (RRID:SCR_018257
cortical layer thickness
gyral linear and sulcal regions
neuronal cell densities
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
Jun 2024
Jun 2024
Historique:
revised:
16
04
2024
received:
13
01
2024
accepted:
09
05
2024
medline:
20
7
2024
pubmed:
20
7
2024
entrez:
20
7
2024
Statut:
ppublish
Résumé
We have examined the number and distribution of NeuN-immunoreactive cortical white matter interstitial cells (WMICs) and compared them to the neurons in layers 1-6 across the overlying cortex in coronal sections from postnatal macaques. The data have been gathered from over 300 selected regions at gyral crowns, at sulci, and at linear regions of the cortex where we also determined cortical layer thicknesses: standard thicknesses and tangential thicknesses. Cortical thicknesses and cell numbers showed variability according to gyral, linear, or sulcal regions. In spite of these variations, our standardized cell numbers in layers 1 to 6b and interstitial cells underlying layer 6b-white matter boundary have shown a consistent correlation between the number of WMICs and the number of layer 5 and 6a cortical neurons on all cortical regions studied: for each WMIC, there are on the order of five cortical neurons in layer 5 and approximately three cortical neurons in layer 6a, irrespective of the origins of the selected cortical area or whether they are from gyral, linear, or sulcal regions. We propose that the number of interstitial neurons in the postnatal macaque cortex is correlated to the density of neurons within layers 5 and 6a and, from a clinical perspective, the change in density or distribution of interstitial neurons in schizophrenia or epilepsy may in fact be linked to the number of layers 5 and 6a neurons.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e25626Subventions
Organisme : NIH HHS
ID : MH113257
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : (UK) BB/X008711/1
Pays : United Kingdom
Organisme : Einstein Stiftung Berlin
Organisme : MRC (UK)
ID : MR/W029073/1
Informations de copyright
© 2024 The Author(s). The Journal of Comparative Neurology published by Wiley Periodicals LLC.
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