Ambient air pollution, covert cerebrovascular disease and cognition: results from the ISSYS study.
air pollution
brain infarction
cerebrovascular disorders
cognitive impairment
particulate matter
Journal
European journal of neurology
ISSN: 1468-1331
Titre abrégé: Eur J Neurol
Pays: England
ID NLM: 9506311
Informations de publication
Date de publication:
19 Jul 2024
19 Jul 2024
Historique:
revised:
19
06
2024
received:
20
01
2024
accepted:
20
06
2024
medline:
20
7
2024
pubmed:
20
7
2024
entrez:
20
7
2024
Statut:
aheadofprint
Résumé
Although air pollution (AP) has been associated with stroke and dementia, data regarding its relationship with covert cerebrovascular disease (cCVD) and cognition over time are sparse. The aim of this study was to explore these relationships. A prospective population-based study of 976 stroke-free and non-demented individuals living in Barcelona, Spain, was conducted during 2010-2016. A land use regression model was used to estimate the exposure of each participant to AP: NO At baseline, 99 participants (10.1%) had covert brain infarcts and 91 (9.3%) had extensive periventricular white matter hyperintensities (WMHs). Marked subcortical WMH progression was seen in 19.7%; the incidence of other covert cerebrovascular lessons ranged between 5% and 6% each. PM Air pollutant predicts the presence and accumulation of cCVD. Its impact on cognitive impairment remains to be determined.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Although air pollution (AP) has been associated with stroke and dementia, data regarding its relationship with covert cerebrovascular disease (cCVD) and cognition over time are sparse. The aim of this study was to explore these relationships.
METHODS
METHODS
A prospective population-based study of 976 stroke-free and non-demented individuals living in Barcelona, Spain, was conducted during 2010-2016. A land use regression model was used to estimate the exposure of each participant to AP: NO
RESULTS
RESULTS
At baseline, 99 participants (10.1%) had covert brain infarcts and 91 (9.3%) had extensive periventricular white matter hyperintensities (WMHs). Marked subcortical WMH progression was seen in 19.7%; the incidence of other covert cerebrovascular lessons ranged between 5% and 6% each. PM
CONCLUSIONS
CONCLUSIONS
Air pollutant predicts the presence and accumulation of cCVD. Its impact on cognitive impairment remains to be determined.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e16404Subventions
Organisme : Instituto de Salud Carlos III
ID : PI14/1535
Organisme : Instituto de Salud Carlos III
ID : PI19/00217
Organisme : Instituto de Salud Carlos III
ID : INT20/00084
Organisme : Instituto de Salud Carlos III
ID : CM20/00218
Organisme : Instituto de Salud Carlos III
ID : CM22/00226
Organisme : European Regional Development Fund
Organisme : Spanish Research Stroke Network
ID : RD/16/0019/0021
Organisme : RICORS-ICTUS-Enfermedades Vasculares Cerebrales
ID : RD21/0006/0007
Organisme : Ramón y Cajal Fellowship
ID : RYC-2017-01892
Organisme : Spanish Ministry of Science, Innovation and Universities
Organisme : European Social Fund
Organisme : Spanish Ministry of Science and Innovation
Organisme : 'Centro de Excelencia Severo Ochoa 2019-2023
ID : CEX2018-000806-S
Organisme : Generalitat de Catalunya
Organisme : CERCA Programme
Informations de copyright
© 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
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