The validity of cardiopulmonary exercise testing for assessing aerobic capacity in neuromuscular diseases.

To determine the content validity of cardiopulmonary exercise testing (CPET) for assessing peak oxygen uptake (VO Baseline assessment of a randomized controlled trial. Academic hospital. Eighty-six adults (age: 58.0 ± 13.9 years) with Charcot-Marie-Tooth disease (n=35), post-polio syndrome (n=26), or other NMD (n=25). Not applicable. Workload, gas exchange variables, heart rate, and ratings of perceived exertion were measured during CPET on a cycle ergometer, supervised by an experienced trained assessor. Muscle strength of the knee extensors was assessed isometrically with a fixed dynamometer. Criteria for confirming maximal cardiorespiratory effort during CPET were established during 3 consensus meetings with an expert group. The percentage of participants meeting these criteria was assessed to quantify content validity. The following criteria were established for maximal cardiorespiratory effort; a plateau in oxygen uptake (VO Most people with NMD achieved maximal cardiorespiratory effort during CPET. Therewith, this study provides high quality evidence of sufficient content validity of VO

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Declaration of competing interest The authors declare that they have no competing interests.