Acute toxicity profiling of medicinal herb

1H NMR serum metabolomics 1H NMR urinary metabolomics Acute toxicity study Ardisia elliptica Metabolic pathway

Journal

Journal of traditional and complementary medicine
ISSN: 2225-4110
Titre abrégé: J Tradit Complement Med
Pays: Netherlands
ID NLM: 101605474

Informations de publication

Date de publication:
Jul 2024
Historique:
received: 11 10 2022
revised: 08 02 2024
accepted: 20 02 2024
medline: 22 7 2024
pubmed: 22 7 2024
entrez: 22 7 2024
Statut: epublish

Résumé

Interest in the safety of herbal medicine is growing rapidly regarding knowledge and challenges in natural products. Hence, this study aimed to reveal the toxicological profile of Acute toxicity study was performed on female and male Sprague Dawley rats with a single oral administration of 2000 mg/kg BW of 70% ethanolic Physical, hematological, biochemical, and histopathological assessments demonstrated the usual rat profile, with no mortality and delayed toxicity 14 days after administration. This study suggested that 2000 mg/kg BW of 70% ethanolic

Sections du résumé

Background and aim UNASSIGNED
Interest in the safety of herbal medicine is growing rapidly regarding knowledge and challenges in natural products. Hence, this study aimed to reveal the toxicological profile of
Experimental procedure UNASSIGNED
Acute toxicity study was performed on female and male Sprague Dawley rats with a single oral administration of 2000 mg/kg BW of 70% ethanolic
Results UNASSIGNED
Physical, hematological, biochemical, and histopathological assessments demonstrated the usual rat profile, with no mortality and delayed toxicity 14 days after administration.
Conclusion UNASSIGNED
This study suggested that 2000 mg/kg BW of 70% ethanolic

Identifiants

DOI: 10.1016/j.jtcme.2024.02.001 PMID: 39035686 PMC: PMC11259702
pubmed: 39035686
doi: 10.1016/j.jtcme.2024.02.001
pii: S2225-4110(24)00011-7
pmc: PMC11259702
doi:

Types de publication

Journal Article

Langues

eng

Pagination

456-466

Informations de copyright

© 2024 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Auteurs

Pei Lou Wong (PL)

Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Nur Khaleeda Zulaikha Zolkeflee (NKZ)

Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Nurul Shazini Ramli (NS)

Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Chin Ping Tan (CP)

Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Azrina Azlan (A)

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Faridah Abas (F)

Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Classifications MeSH