Association Between Traumatic Brain Injury and Cognitive Decline Among Middle-to-Older Aged Men in the Vietnam Era Twin Study of Aging.

aging cognition epidemiology prospective cohort traumatic brain injury

Journal

Neurotrauma reports
ISSN: 2689-288X
Titre abrégé: Neurotrauma Rep
Pays: United States
ID NLM: 101773091

Informations de publication

Date de publication:
2024
Historique:
pmc-release: 17 06 2025
medline: 22 7 2024
pubmed: 22 7 2024
entrez: 22 7 2024
Statut: epublish

Résumé

Traumatic brain injury (TBI) is associated with increased risk of dementia. However, whether TBI is associated with greater cognitive decline over time in specific cognitive domains among older adults is not well understood. This prospective cohort study used data from 1476 male Vietnam Era Twin Study of Aging participants (average age at study entry = 57.9 years, range = 51-71 years; 97.6% non-Hispanic; 92.5% White) collected from 2003 to 2019, who had complete information on prior TBI. Participants completed a comprehensive neuropsychological assessment at up to three visits over up to a 12-year follow-up period during which they also self-reported their history of TBI. Multivariable, linear mixed-effects models were used to assess associations between TBI and cognitive performance trajectories. Effect measure modification by apolipoprotein E (

Identifiants

DOI: 10.1089/neur.2024.0034 PMID: 39036434 PMC: PMC11257108
pubmed: 39036434
doi: 10.1089/neur.2024.0034
pii: 10.1089/neur.2024.0034
pmc: PMC11257108
doi:

Types de publication

Journal Article

Langues

eng

Pagination

563-573

Informations de copyright

© Alexander Ivan B. Posis et al., 2024; Published by Mary Ann Liebert, Inc.

Auteurs

Alexander Ivan B Posis (AIB)

Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
School of Public Health, San Diego State University, San Diego, California, USA.

John E Alcaraz (JE)

School of Public Health, San Diego State University, San Diego, California, USA.

Humberto Parada (H)

School of Public Health, San Diego State University, San Diego, California, USA.
Moores Cancer Center, UC San Diego Health, La Jolla, California, USA.
Department of Radiation Medicine & Applied Science, University of California, San Diego, La Jolla, California, USA.

Aladdin H Shadyab (AH)

Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.

Jeremy A Elman (JA)

Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.

Matthew S Panizzon (MS)

Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.

Chandra A Reynolds (CA)

Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA.

Carol E Franz (CE)

Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.

William S Kremen (WS)

Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.

Linda K McEvoy (LK)

Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.

Classifications MeSH