Acute myeloid leukemia with
Acute myeloid leukemia
ETV6::CHIC2; basophilia
ETV6::PDGFRA
FISH
Next Generation Sequencing
flow cytometry
immunophenotype
Journal
Hematology (Amsterdam, Netherlands)
ISSN: 1607-8454
Titre abrégé: Hematology
Pays: England
ID NLM: 9708388
Informations de publication
Date de publication:
Dec 2024
Dec 2024
Historique:
medline:
22
7
2024
pubmed:
22
7
2024
entrez:
22
7
2024
Statut:
ppublish
Résumé
Acute myeloid leukemia (AML) with We report a case of AML with We confirmed a rare case of AML with Immunophenotype analysis is necessary to detect the expression of CD7 when encountering pseudo-lymphocytes with multilineage dysplasia and basophilia. FISH and RT-PCR are still indispensable means of diagnosis of fusion genes in hematologic malignancies but can only detect a limited number of known partner genes and fusion genes with known break points. NGS can achieve sequence analysis indiscriminately and detect all fusion transcripts theoretically, greatly improving the detection range. NGS sequencing is required for t(4;12)(q11;p13) in AML that are not accompanied by eosinophilia.
Identifiants
pubmed: 39037342
doi: 10.1080/16078454.2024.2381170
doi:
Substances chimiques
Oncogene Proteins, Fusion
0
ETS Translocation Variant 6 Protein
0
Repressor Proteins
0
Proto-Oncogene Proteins c-ets
0
Types de publication
Journal Article
Case Reports
Langues
eng
Sous-ensembles de citation
IM