18F-Flortaucipir (AV1451) imaging identifies grey matter atrophy in retired athletes.

Athletes Chronic traumatic encephalopathy Concussion Neurodegeneration Pet Tau

Journal

Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161

Informations de publication

Date de publication:
22 Jul 2024
Historique:
received: 10 03 2024
accepted: 07 07 2024
revised: 06 06 2024
medline: 22 7 2024
pubmed: 22 7 2024
entrez: 22 7 2024
Statut: aheadofprint

Résumé

The long-term consequences of concussions may include pathological neurodegeneration as seen in Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE). Tau-PET showed promise as a method to detect tau pathology of CTE, but more studies are needed OBJECTIVE: This study aimed (1) to assess the association of imaging evidence of tau pathology with brain volumes in retired athletes and (2) to examine the relationship between tau-PET and neuropsychological functioning. Former contact sport athletes were recruited through the Canadian Football League Alumni Association or the Canadian Concussion Centre clinic. Athletes completed MRI, [ 47 retired contact sport athletes negative for AD (age:51 ± 14; concussions/athlete:15 ± 2) and 54 normal controls (age:50 ± 13) were included. Tau-PET positive voxels had significantly lower GM volumes, compared to tau-PET negative voxels (- 0.37 ± 0.41 vs. - 0.31 ± 0.37, paired p = .006). There was a significant relationship between GM tau-PET % positivity and memory composite score (r =  - .366, p = .02), controlled for age, PET scanner, and PET scan duration. There was no relationship between tau-PET measures and concussion number, or years of sport played. A higher tau-PET signal was associated with reduced GM volumes and lower memory scores. Tau-PET may be useful for identifying those at risk for neurodegeneration.

Sections du résumé

BACKGROUND BACKGROUND
The long-term consequences of concussions may include pathological neurodegeneration as seen in Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE). Tau-PET showed promise as a method to detect tau pathology of CTE, but more studies are needed OBJECTIVE: This study aimed (1) to assess the association of imaging evidence of tau pathology with brain volumes in retired athletes and (2) to examine the relationship between tau-PET and neuropsychological functioning.
METHODS METHODS
Former contact sport athletes were recruited through the Canadian Football League Alumni Association or the Canadian Concussion Centre clinic. Athletes completed MRI, [
RESULTS RESULTS
47 retired contact sport athletes negative for AD (age:51 ± 14; concussions/athlete:15 ± 2) and 54 normal controls (age:50 ± 13) were included. Tau-PET positive voxels had significantly lower GM volumes, compared to tau-PET negative voxels (- 0.37 ± 0.41 vs. - 0.31 ± 0.37, paired p = .006). There was a significant relationship between GM tau-PET % positivity and memory composite score (r =  - .366, p = .02), controlled for age, PET scanner, and PET scan duration. There was no relationship between tau-PET measures and concussion number, or years of sport played.
CONCLUSION CONCLUSIONS
A higher tau-PET signal was associated with reduced GM volumes and lower memory scores. Tau-PET may be useful for identifying those at risk for neurodegeneration.

Identifiants

DOI: 10.1007/s00415-024-12573-0 PMID: 39037476
pubmed: 39037476
doi: 10.1007/s00415-024-12573-0
pii: 10.1007/s00415-024-12573-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Swedish Research Council
ID : #2022-01018
Organisme : Swedish Research Council
ID : #2019-02397
Organisme : Swedish Research Council
ID : 2017-00915
Organisme : Swedish State Support for Clinical Research
ID : ALFGBG-71320
Organisme : Alzheimer's Drug Discovery Foundation
ID : 201809-2016862
Organisme : Alzheimer's Drug Discovery Foundation
ID : RDAPB-201809-2016615
Organisme : AD Strategic Fund and the Alzheimer's Association
ID : #ADSF-21-831376-C
Organisme : AD Strategic Fund and the Alzheimer's Association
ID : #ADSF-21-831381-C
Organisme : AD Strategic Fund and the Alzheimer's Association
ID : #ADSF-21-831377-C
Organisme : Hjärnfonden
ID : FO2022-0270
Organisme : Hjärnfonden
ID : FO2017-0243
Organisme : European Union Joint Programme - Neurodegenerative Disease Research
ID : JPND2021-00694
Organisme : UK Dementia Research Institute at UCL
ID : UKDRI-1003
Organisme : Swedish Alzheimer Foundation
ID : AF-742881
Organisme : Swedish Alzheimer Foundation
ID : AF-930627
Organisme : ALF-agreement
ID : ALFGBG-715986
Organisme : European Union Joint Program for Neurodegenerative Disorders
ID : JPND2019-466-236
Organisme : National Institute of Health (NIH)
ID : 1R01AG068398-01
Organisme : BrightFocus Foundation
ID : A2020812F
Organisme : Swedish Brain Foundation
ID : FO2020-0240
Organisme : Agneta Prytz-Folkes & Gösta Folkes Foundation
ID : 2020-00124

Informations de copyright

© 2024. The Author(s).

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Auteurs

Anna Vasilevskaya (A)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 6th Floor 6KD-407, Toronto, ON, M5T 2S8, Canada.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Division of Neurology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
ORCID: 0000-0001-7398-9620

Chloe Anastassiadis (C)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 6th Floor 6KD-407, Toronto, ON, M5T 2S8, Canada.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Division of Neurology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Simrika Thapa (S)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 6th Floor 6KD-407, Toronto, ON, M5T 2S8, Canada.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Division of Neurology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Foad Taghdiri (F)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 6th Floor 6KD-407, Toronto, ON, M5T 2S8, Canada.
Division of Neurology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.

Mozhgan Khodadadi (M)

Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.

Namita Multani (N)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 6th Floor 6KD-407, Toronto, ON, M5T 2S8, Canada.
Division of Neurology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Pablo Rusjan (P)

Douglas Mental Health University Institute, Montreal, QC, Canada.
Department of Psychiatry, McGill University, Montreal, QC, Canada.

Miracle Ozzoude (M)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 6th Floor 6KD-407, Toronto, ON, M5T 2S8, Canada.

Apameh Tarazi (A)

Division of Neurology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.

Asma Mushtaque (A)

Division of Neurology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Richard Wennberg (R)

Division of Neurology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.

Sylvain Houle (S)

Brain Health Imaging Centre, Campbell Research Institute, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Robin Green (R)

Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
KITE Research Institute, University Health Network, Toronto, ON, Canada.

Brenda Colella (B)

Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
KITE Research Institute, University Health Network, Toronto, ON, Canada.

Neil Vasdev (N)

Brain Health Imaging Centre, Campbell Research Institute, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Kaj Blennow (K)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

Henrik Zetterberg (H)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
UK Dementia Research Institute at UCL, London, UK.
Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.

Thomas Karikari (T)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

Christine Sato (C)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 6th Floor 6KD-407, Toronto, ON, M5T 2S8, Canada.

Danielle Moreno (D)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 6th Floor 6KD-407, Toronto, ON, M5T 2S8, Canada.

Ekaterina Rogaeva (E)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 6th Floor 6KD-407, Toronto, ON, M5T 2S8, Canada.

David Mikulis (D)

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Division of Neuroradiology, Joint Department of Medical Imaging, University Health Network, Toronto, ON, Canada.

Karen Deborah Davis (KD)

Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Department of Surgery, University of Toronto, Toronto, ON, Canada.

Charles Tator (C)

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Division of Neurosurgery, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.

Maria Carmela Tartaglia (MC)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Avenue, 6th Floor 6KD-407, Toronto, ON, M5T 2S8, Canada. carmela.tartaglia@uhn.ca.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada. carmela.tartaglia@uhn.ca.
Division of Neurology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. carmela.tartaglia@uhn.ca.
Canadian Concussion Centre, Toronto Western Hospital, Krembil Brain Institute, University Health Network, Toronto, ON, Canada. carmela.tartaglia@uhn.ca.

Classifications MeSH