Identification by Synthesis: Imidacins, Urocanate-Derived Alkaloids from the Myxobacterium

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
22 Jul 2024
Historique:
medline: 22 7 2024
pubmed: 22 7 2024
entrez: 22 7 2024
Statut: aheadofprint

Résumé

Innovative discovery approaches such as genome-mining and metabolomics-inspired methods have reshaped the natural product research field, complementing traditional bioactivity-based screens and allowing hitherto unseen compounds to be uncovered from previously investigated producers. In line with these trends, we report here imidacins, a novel class of secondary metabolites specific to the myxobacterial genus

Identifiants

DOI: 10.1021/acs.orglett.4c02036 PMID: 39037587
pubmed: 39037587
doi: 10.1021/acs.orglett.4c02036
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Michael Kostka (M)

Institute of Organic Chemistry, Technische Universität Braunschweig, Hagenring 30, 38106 Braunschweig, Germany.

Daniel Krug (D)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Microbial Natural Products, Helmholtz Centre for Infection Research (HZI) and Department of Pharmaceutical Biotechnology, Universität des Saarlandes, Campus E8.1, 66123 Saarbrücken, Germany.
German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany.

Jennifer Herrmann (J)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Microbial Natural Products, Helmholtz Centre for Infection Research (HZI) and Department of Pharmaceutical Biotechnology, Universität des Saarlandes, Campus E8.1, 66123 Saarbrücken, Germany.
ORCID: 0000-0003-3398-9938

Jeroen S Dickschat (JS)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Microbial Natural Products, Helmholtz Centre for Infection Research (HZI) and Department of Pharmaceutical Biotechnology, Universität des Saarlandes, Campus E8.1, 66123 Saarbrücken, Germany.
Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany.
ORCID: 0000-0002-0102-0631

Julia Meyer (J)

Institute of Organic Chemistry, Technische Universität Braunschweig, Hagenring 30, 38106 Braunschweig, Germany.

Rolf Müller (R)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Microbial Natural Products, Helmholtz Centre for Infection Research (HZI) and Department of Pharmaceutical Biotechnology, Universität des Saarlandes, Campus E8.1, 66123 Saarbrücken, Germany.
German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany.

Stefan Schulz (S)

Institute of Organic Chemistry, Technische Universität Braunschweig, Hagenring 30, 38106 Braunschweig, Germany.
ORCID: 0000-0002-4810-324X

Classifications MeSH