Protein Identification for Stroke Progression via Mendelian Randomization in Million Veteran Program and UK Biobank.

Humans Mendelian Randomization Analysis Biological Specimen Banks Genome-Wide Association Study Male Stroke / genetics Female United Kingdom / epidemiology Middle Aged Veterans Aged Disease Progression Polymorphism, Single Nucleotide / genetics Ischemic Stroke / genetics Risk Factors Quantitative Trait Loci UK Biobank
blood proteins genome-wide association study inflammation prognosis stroke

Journal

Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266

Informations de publication

Date de publication:
Aug 2024
Historique:
medline: 22 7 2024
pubmed: 22 7 2024
entrez: 22 7 2024
Statut: ppublish

Résumé

Individuals who have experienced a stroke, or transient ischemic attack, face a heightened risk of future cardiovascular events. Identification of genetic and molecular risk factors for subsequent cardiovascular outcomes may identify effective therapeutic targets to improve prognosis after an incident stroke. We performed genome-wide association studies for subsequent major adverse cardiovascular events (MACE; n Two variants were significantly associated with subsequent cardiovascular events: rs76472767 near gene We found evidence that 2 proteins with little effect on incident stroke appear to influence subsequent MACE after incident AIS. These associations suggest that inflammation is a contributing factor to subsequent MACE outcomes after incident AIS and highlights potential novel targets.

Sections du résumé

BACKGROUND UNASSIGNED
Individuals who have experienced a stroke, or transient ischemic attack, face a heightened risk of future cardiovascular events. Identification of genetic and molecular risk factors for subsequent cardiovascular outcomes may identify effective therapeutic targets to improve prognosis after an incident stroke.
METHODS UNASSIGNED
We performed genome-wide association studies for subsequent major adverse cardiovascular events (MACE; n
RESULTS UNASSIGNED
Two variants were significantly associated with subsequent cardiovascular events: rs76472767 near gene
CONCLUSIONS UNASSIGNED
We found evidence that 2 proteins with little effect on incident stroke appear to influence subsequent MACE after incident AIS. These associations suggest that inflammation is a contributing factor to subsequent MACE outcomes after incident AIS and highlights potential novel targets.

Identifiants

DOI: 10.1161/STROKEAHA.124.047103 PMID: 39038097
pubmed: 39038097
doi: 10.1161/STROKEAHA.124.047103
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2045-2054

Déclaration de conflit d'intérêts

Dr Tilling reports grants from the National Institute for Health and Care Research; grants from Wellcome Trust; and grants from Medical Research Council. Dr Gaunt reports grants from the National Institute for Health and Care Research (UK); grants from Biogen; grants from UK Medical Research Council; and grants from GlaxoSmithKline. Dr Gaziano reports grants from the US Department of Veterans Affairs. Dr Davey Smith reports grants from the Medical Research Council. Dr Peloso reports support from Veterans Health Administration; employment by Boston University; compensation from the American Heart Association for consultant services; and grants from the National Institutes of Health. Dr Hartley started working for Novo Nordisk after contributing to this article. The other authors report no conflicts.

Auteurs

Andrew R Elmore (AR)

NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).
MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).

Nimish Adhikari (N)

Veteran's Affairs Healthcare System, Boston, MA (N.A., D.C.P., J.P.C., J.M.G., K.C., G.M.P.).
Department of Biostatistics, Boston University School of Public Health, MA (N.A., G.M.P.).

April E Hartley (AE)

NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).
MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).

Hugo Javier Aparicio (HJ)

Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, MA (H.J.A.).
Boston Medical Center, MA (H.J.A.).

Daniel C Posner (DC)

Veteran's Affairs Healthcare System, Boston, MA (N.A., D.C.P., J.P.C., J.M.G., K.C., G.M.P.).

Gibran Hemani (G)

NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).
MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).

Kate Tilling (K)

NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).
MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).

Tom R Gaunt (TR)

NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).
MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).

Peter W F Wilson (PWF)

Atlanta VA Medical Center, GA (P.W.F.W.).

Juan P Casas (JP)

Veteran's Affairs Healthcare System, Boston, MA (N.A., D.C.P., J.P.C., J.M.G., K.C., G.M.P.).
Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.P.C., J.M.G., K.C.).

John Michael Gaziano (JM)

Veteran's Affairs Healthcare System, Boston, MA (N.A., D.C.P., J.P.C., J.M.G., K.C., G.M.P.).
Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.P.C., J.M.G., K.C.).

George Davey Smith (G)

NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).
MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).

Lavinia Paternoster (L)

NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).
MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, United Kingdom (A.R.E., A.E.H., G.H., K.T., T.R.G., G.D.S., L.P.).

Kelly Cho (K)

Veteran's Affairs Healthcare System, Boston, MA (N.A., D.C.P., J.P.C., J.M.G., K.C., G.M.P.).
Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.P.C., J.M.G., K.C.).

Gina M Peloso (GM)

Veteran's Affairs Healthcare System, Boston, MA (N.A., D.C.P., J.P.C., J.M.G., K.C., G.M.P.).
Department of Biostatistics, Boston University School of Public Health, MA (N.A., G.M.P.).

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Protein Identification for Stroke Progression...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Protein Identification for Stroke Progression...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Biobanques › Protein Identification for Stroke Progression...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Protein Identification for Stroke Progression...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Protein Identification for Stroke Progression...
questionsmedicales.fr › Régions géographiques › Europe › Royaume-Uni › Protein Identification for Stroke Progression...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Protein Identification for Stroke Progression...
questionsmedicales.fr › Personnes › Anciens combattants › Protein Identification for Stroke Progression...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Protein Identification for Stroke Progression...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Protein Identification for Stroke Progression...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Protein Identification for Stroke Progression...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Accident vasculaire cérébral ischémique › Protein Identification for Stroke Progression...
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questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Protein Identification for Stroke Progression...