Differences in the cerebral amyloid angiopathy proteome in Alzheimer's disease and mild cognitive impairment.
Alzheimer’s disease
Cerebral amyloid angiopathy
Proteomics
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
22 Jul 2024
22 Jul 2024
Historique:
received:
04
04
2024
accepted:
12
07
2024
revised:
11
07
2024
medline:
23
7
2024
pubmed:
23
7
2024
entrez:
22
7
2024
Statut:
epublish
Résumé
Cerebral amyloid angiopathy (CAA) is characterized by amyloid beta (Aβ) deposition in cerebrovasculature. It is prevalent with aging and Alzheimer's disease (AD), associated with intracerebral hemorrhage, and contributes to cognitive deficits. To better understand molecular mechanisms, CAA(+) and CAA(-) vessels were microdissected from paraffin-embedded autopsy temporal cortex of age-matched Control (n = 10), mild cognitive impairment (MCI; n = 4), and sporadic AD (n = 6) cases, followed by label-free quantitative mass spectrometry. 257 proteins were differentially abundant in CAA(+) vessels compared to neighboring CAA(-) vessels in MCI, and 289 in AD (p < 0.05, fold-change > 1.5). 84 proteins changed in the same direction in both groups, and many changed in the same direction among proteins significant in at least one group (p < 0.0001, R
Identifiants
pubmed: 39039355
doi: 10.1007/s00401-024-02767-1
pii: 10.1007/s00401-024-02767-1
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9Subventions
Organisme : NIA NIH HHS
ID : P01AG060882
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG066512
Pays : United States
Informations de copyright
© 2024. The Author(s).
Références
Askenazi M, Kavanagh T, Pires G, Ueberheide B, Wisniewski T, Drummond E (2023) Compilation of reported protein changes in the brain in Alzheimer’s disease. Nat Commun 14:4466. https://doi.org/10.1038/s41467-023-40208-x
doi: 10.1038/s41467-023-40208-x
pubmed: 37491476
pmcid: 10368642
Bennett DA, Buchman AS, Boyle PA, Barnes LL, Wilson RS, Schneider JA (2018) Religious orders study and rush memory and aging project. J Alzheimers Dis 64:S161–S189. https://doi.org/10.3233/JAD-179939
doi: 10.3233/JAD-179939
pubmed: 29865057
pmcid: 6380522
Bos I, Verhey FR, Ramakers I, Jacobs HIL, Soininen H, Freund-Levi Y et al (2017) Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimers Res Ther 9:101. https://doi.org/10.1186/s13195-017-0328-9
doi: 10.1186/s13195-017-0328-9
pubmed: 29284531
pmcid: 5747152
Boyle PA, Yu L, Nag S, Leurgans S, Wilson RS, Bennett DA et al (2015) Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons. Neurology 85:1930–1936. https://doi.org/10.1212/WNL.0000000000002175
doi: 10.1212/WNL.0000000000002175
pubmed: 26537052
pmcid: 4664125
Carrano A, Hoozemans JJ, van der Vies SM, Rozemuller AJ, van Horssen J, de Vries HE (2011) Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy. Antioxid Redox Signal 15:1167–1178. https://doi.org/10.1089/ars.2011.3895
doi: 10.1089/ars.2011.3895
pubmed: 21294650
Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP et al (2017) Emerging concepts in sporadic cerebral amyloid angiopathy. Brain 140:1829–1850. https://doi.org/10.1093/brain/awx047
doi: 10.1093/brain/awx047
pubmed: 28334869
pmcid: 6059159
Cheng X, He P, Yao H, Dong Q, Li R, Shen Y (2014) Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy. Neurology 82:1707–1715. https://doi.org/10.1212/WNL.0000000000000403
doi: 10.1212/WNL.0000000000000403
pubmed: 24739782
pmcid: 4032211
Dewing JM, Carare RO, Lotery AJ, Ratnayaka JA (2019) The diverse roles of TIMP-3: insights into degenerative diseases of the senescent retina and brain. Cells. https://doi.org/10.3390/cells9010039
doi: 10.3390/cells9010039
pubmed: 31877820
pmcid: 7017234
Doellinger J, Schneider A, Hoeller M, Lasch P (2020) Sample preparation by easy extraction and digestion (SPEED)—a universal, rapid, and detergent-free protocol for proteomics based on acid extraction. Mol Cell Proteom 19:209–222. https://doi.org/10.1074/mcp.TIR119.001616
doi: 10.1074/mcp.TIR119.001616
Drummond E, Kavanagh T, Pires G, Marta-Ariza M, Kanshin E, Nayak S et al (2022) The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome. Acta Neuropathol Commun 10:53. https://doi.org/10.1186/s40478-022-01356-1
doi: 10.1186/s40478-022-01356-1
pubmed: 35418158
pmcid: 9008934
Drummond E, Nayak S, Faustin A, Pires G, Hickman RA, Askenazi M et al (2017) Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer’s disease. Acta Neuropathol 133:933–954. https://doi.org/10.1007/s00401-017-1691-0
doi: 10.1007/s00401-017-1691-0
pubmed: 28258398
pmcid: 5503748
Drummond E, Nayak S, Pires G, Ueberheide B, Wisniewski T (2018) Isolation of amyloid plaques and neurofibrillary tangles from archived Alzheimer’s disease tissue using laser-capture microdissection for downstream proteomics. Methods Mol Biol 1723:319–334. https://doi.org/10.1007/978-1-4939-7558-7_18
doi: 10.1007/978-1-4939-7558-7_18
pubmed: 29344869
pmcid: 5811767
Drummond E, Pires G, MacMurray C, Askenazi M, Nayak S, Bourdon M et al (2020) Phosphorylated tau interactome in the human Alzheimer’s disease brain. Brain. https://doi.org/10.1093/brain/awaa223
doi: 10.1093/brain/awaa223
pubmed: 32812023
pmcid: 7526722
Evans HT, Benetatos J, van Roijen M, Bodea LG, Götz J (2019) Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling. EMBO J 38:e101174. https://doi.org/10.15252/embj.2018101174
doi: 10.15252/embj.2018101174
pubmed: 31268600
pmcid: 6600635
Fisher RA, Miners JS, Love S (2022) Pathological changes within the cerebral vasculature in Alzheimer’s disease: new perspectives. Brain Pathol 32:e13061. https://doi.org/10.1111/bpa.13061
doi: 10.1111/bpa.13061
pubmed: 35289012
pmcid: 9616094
Foote M, Zhou Y (2012) 14-3-3 proteins in neurological disorders. Int J Biochem Mol Biol 3:152–164
pubmed: 22773956
pmcid: 3388734
Freeze WM, Jacobs HIL, Schreuder FHBM, van Oostenbrugge RJ, Backes WH, Verhey FR et al (2018) Blood–brain barrier dysfunction in small vessel disease related intracerebral hemorrhage. Front Neurol 9:926. https://doi.org/10.3389/fneur.2018.00926
doi: 10.3389/fneur.2018.00926
pubmed: 30483207
pmcid: 6240684
Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, Pruzin J, Sperling R, van Veluw SJ (2020) Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways. Nat Rev Neurol 16:30–42. https://doi.org/10.1038/s41582-019-0281-2
doi: 10.1038/s41582-019-0281-2
pubmed: 31827267
Hampel H, Elhage A, Cho M, Apostolova LG, Nicoll JAR, Atri A (2023) Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics. Brain. https://doi.org/10.1093/brain/awad188
doi: 10.1093/brain/awad188
pubmed: 37280110
pmcid: 10629981
Handa T, Sasaki H, Takao M, Tano M, Uchida Y (2022) Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method. Fluids Barriers CNS 19:56. https://doi.org/10.1186/s12987-022-00351-x
doi: 10.1186/s12987-022-00351-x
pubmed: 35778717
pmcid: 9250250
Heberle H, Meirelles GV, da Silva FR, Telles GP, Minghim R (2015) InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams. BMC Bioinform 16:169. https://doi.org/10.1186/s12859-015-0611-3
doi: 10.1186/s12859-015-0611-3
Herline K, Drummond E, Wisniewski T (2018) Recent advancements toward therapeutic vaccines against Alzheimer’s disease. Expert Rev Vaccines 17:707–721. https://doi.org/10.1080/14760584.2018.1500905
doi: 10.1080/14760584.2018.1500905
pubmed: 30005578
Hondius DC, Eigenhuis KN, Morrema THJ, van der Schors RC, van Nierop P, Bugiani M et al (2018) Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease. Acta Neuropathol Commun 6:46. https://doi.org/10.1186/s40478-018-0540-2
doi: 10.1186/s40478-018-0540-2
pubmed: 29860944
pmcid: 5985582
Howe MD, McCullough LD, Urayama A (2020) The role of basement membranes in cerebral amyloid angiopathy. Front Physiol 11:601320. https://doi.org/10.3389/fphys.2020.601320
doi: 10.3389/fphys.2020.601320
pubmed: 33329053
pmcid: 7732667
Hsieh YC, Guo C, Yalamanchili HK, Abreha M, Al-Ouran R, Li Y et al (2019) Tau-mediated disruption of the spliceosome triggers cryptic RNA splicing and neurodegeneration in Alzheimer’s disease. Cell Rep 29:301-316.e310. https://doi.org/10.1016/j.celrep.2019.08.104
doi: 10.1016/j.celrep.2019.08.104
pubmed: 31597093
pmcid: 6919331
Inoue Y, Ueda M, Tasaki M, Takeshima A, Nagatoshi A, Masuda T et al (2017) Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy. Acta Neuropathol 134:605–617. https://doi.org/10.1007/s00401-017-1720-z
doi: 10.1007/s00401-017-1720-z
pubmed: 28478503
Johnson ECB, Carter EK, Dammer EB, Duong DM, Gerasimov ES, Liu Y et al (2022) Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level. Nat Neurosci 25:213–225. https://doi.org/10.1038/s41593-021-00999-y
doi: 10.1038/s41593-021-00999-y
pubmed: 35115731
pmcid: 8825285
Jäkel L, Kuiperij HB, Gerding LP, Custers EEM, van den Berg E, Jolink WMT et al (2020) Disturbed balance in the expression of MMP9 and TIMP3 in cerebral amyloid angiopathy-related intracerebral haemorrhage. Acta Neuropathol Commun 8:99. https://doi.org/10.1186/s40478-020-00972-z
doi: 10.1186/s40478-020-00972-z
pubmed: 32631441
pmcid: 7336459
Kavanagh T, Halder A, Drummond E (2022) Tau interactome and RNA binding proteins in neurodegenerative diseases. Mol Neurodegener 17:66. https://doi.org/10.1186/s13024-022-00572-6
doi: 10.1186/s13024-022-00572-6
pubmed: 36253823
pmcid: 9575286
Koemans EA, Chhatwal JP, van Veluw SJ, van Etten ES, van Osch MJP, van Walderveen MAA et al (2023) Progression of cerebral amyloid angiopathy: a pathophysiological framework. Lancet Neurol 22:632–642. https://doi.org/10.1016/S1474-4422(23)00114-X
doi: 10.1016/S1474-4422(23)00114-X
pubmed: 37236210
Leitner D, Pires G, Kavanagh T, Kanshin E, Askenazi M, Ueberheide B et al (2024) Similar brain proteomic signatures in Alzheimer’s disease and epilepsy. Acta Neuropathol 147:27. https://doi.org/10.1007/s00401-024-02683-4
doi: 10.1007/s00401-024-02683-4
pubmed: 38289539
pmcid: 10827928
Leitner DF, Kanshin E, Askenazi M, Siu Y, Friedman D, Devore S et al (2022) Pilot study evaluating everolimus molecular mechanisms in tuberous sclerosis complex and focal cortical dysplasia. PLoS ONE 17:e0268597. https://doi.org/10.1371/journal.pone.0268597
doi: 10.1371/journal.pone.0268597
pubmed: 35587487
pmcid: 9119437
Leitner DF, Kanshin E, Faustin A, Thierry M, Friedman D, Devore S et al (2023) Localized proteomic differences in the choroid plexus of Alzheimer’s disease and epilepsy patients. Front Neurol 14:1221775. https://doi.org/10.3389/fneur.2023.1221775
doi: 10.3389/fneur.2023.1221775
pubmed: 37521285
pmcid: 10379643
Leitner DF, Mills JD, Pires G, Faustin A, Drummond E, Kanshin E et al (2021) Proteomics and transcriptomics of the hippocampus and cortex in SUDEP and high-risk SUDEP patients. Neurology 96:e2639–e2652. https://doi.org/10.1212/wnl.0000000000011999
doi: 10.1212/wnl.0000000000011999
pubmed: 33910938
pmcid: 8205452
Leitner DF, William C, Faustin A, Askenazi M, Kanshin E, Snuderl M et al (2022) Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood. Acta Neuropathol 143:585–599. https://doi.org/10.1007/s00401-022-02414-7
doi: 10.1007/s00401-022-02414-7
pubmed: 35333953
pmcid: 8953962
Lertkiatmongkol P, Liao D, Mei H, Hu Y, Newman PJ (2016) Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31). Curr Opin Hematol 23:253–259. https://doi.org/10.1097/MOH.0000000000000239
doi: 10.1097/MOH.0000000000000239
pubmed: 27055047
pmcid: 4986701
Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M et al (2023) Aβ Amyloid scaffolds the accumulation of matrisome and additional proteins in Alzheimer’s disease. bioRxiv. https://doi.org/10.1101/2023.11.29.568318
doi: 10.1101/2023.11.29.568318
pubmed: 38076912
pmcid: 10705437
Love S, Chalmers K, Ince P, Esiri M, Attems J, Jellinger K et al (2014) Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue. Am J Neurodegener Dis 3:19–32
pubmed: 24754000
pmcid: 3986608
Low YH, Asi Y, Foti SC, Lashley T (2021) Heterogeneous nuclear ribonucleoproteins: implications in neurological diseases. Mol Neurobiol 58:631–646. https://doi.org/10.1007/s12035-020-02137-4
doi: 10.1007/s12035-020-02137-4
pubmed: 33000450
Magaki S, Tang Z, Tung S, Williams CK, Lo D, Yong WH et al (2018) The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier. Neurobiol Aging 70:70–77. https://doi.org/10.1016/j.neurobiolaging.2018.06.004
doi: 10.1016/j.neurobiolaging.2018.06.004
pubmed: 30007166
pmcid: 6146962
Malek-Ahmadi M, Perez SE, Chen K, Mufson EJ (2020) Braak stage, cerebral amyloid angiopathy, and cognitive decline in early Alzheimer’s disease. J Alzheimers Dis 74:189–197. https://doi.org/10.3233/JAD-191151
doi: 10.3233/JAD-191151
pubmed: 31985469
pmcid: 10026689
Manousopoulou A, Gatherer M, Smith C, Nicoll JAR, Woelk CH, Johnson M et al (2017) Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy. Neuropathol Appl Neurobiol 43:492–504. https://doi.org/10.1111/nan.12342
doi: 10.1111/nan.12342
pubmed: 27543695
Masurkar A, Marsh K, Morgan B, Leitner D, Wisniewski T (2024) Factors affecting resilience and prevention of Alzheimer’s disease. Ann Neurol (in press)
Miller DL, Potempska A, Wegiel J, Mehta PD (2011) High-affinity rabbit monoclonal antibodies specific for amyloid peptides amyloid-β40 and amyloid-β42. J Alzheimers Dis 23:293–305. https://doi.org/10.3233/JAD-2010-101341
doi: 10.3233/JAD-2010-101341
pubmed: 21116049
Ojo JO, Reed JM, Crynen G, Vallabhaneni P, Evans J, Shackleton B et al (2021) Molecular pathobiology of the cerebrovasculature in aging and in alzheimers disease cases with cerebral amyloid angiopathy. Front Aging Neurosci 13:658605. https://doi.org/10.3389/fnagi.2021.658605
doi: 10.3389/fnagi.2021.658605
pubmed: 34079449
pmcid: 8166206
Pennington KL, Chan TY, Torres MP, Andersen JL (2018) The dynamic and stress-adaptive signaling hub of 14–3-3: emerging mechanisms of regulation and context-dependent protein-protein interactions. Oncogene 37:5587–5604. https://doi.org/10.1038/s41388-018-0348-3
doi: 10.1038/s41388-018-0348-3
pubmed: 29915393
pmcid: 6193947
Pfeifer LA, White LR, Ross GW, Petrovitch H, Launer LJ (2002) Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study. Neurology 58:1629–1634
doi: 10.1212/WNL.58.11.1629
pubmed: 12058090
Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M et al (2002) Cerebral hemorrhage after passive anti-Aβ immunotherapy. Science 298:1379
doi: 10.1126/science.1078259
pubmed: 12434053
Pfister AS (2019) Emerging role of the nucleolar stress response in autophagy. Front Cell Neurosci 13:156. https://doi.org/10.3389/fncel.2019.00156
doi: 10.3389/fncel.2019.00156
pubmed: 31114481
pmcid: 6503120
Piazza F, Winblad B (2016) Amyloid-related imaging abnormalities (ARIA) in immunotherapy trials for Alzheimer’s disease: need for prognostic biomarkers? J Alzheimers Dis 52:417–420. https://doi.org/10.3233/JAD-160122
doi: 10.3233/JAD-160122
pubmed: 27031492
Pires G, Leitner D, Drummond E, Kanshin E, Nayak S, Askenazi M et al (2021) Proteomic differences in the hippocampus and cortex of epilepsy brain tissue. Brain Commun 3:fcab021. https://doi.org/10.1093/braincomms/fcab021
doi: 10.1093/braincomms/fcab021
pubmed: 34159317
pmcid: 8214864
Rabin JS, Nichols E, La Joie R, Casaletto KB, Palta P, Dams-O’Connor K et al (2022) Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline. Brain 145:2823–2833. https://doi.org/10.1093/brain/awac178
doi: 10.1093/brain/awac178
pubmed: 35759327
pmcid: 9420012
Salloway S, Chalkias S, Barkhof F, Burkett P, Barakos J, Purcell D et al (2022) Amyloid-related imaging abnormalities in 2 phase 3 studies evaluating aducanumab in patients with early Alzheimer disease. JAMA Neurol 79:13–21. https://doi.org/10.1001/jamaneurol.2021.4161
doi: 10.1001/jamaneurol.2021.4161
pubmed: 34807243
Schneider JA, Arvanitakis Z, Bang W, Bennett DA (2007) Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69:2197–2204. https://doi.org/10.1212/01.wnl.0000271090.28148.24
doi: 10.1212/01.wnl.0000271090.28148.24
pubmed: 17568013
Seyfried NT, Dammer EB, Swarup V, Nandakumar D, Duong DM, Yin L et al (2017) A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer’s disease. Cell Syst 4:60-72.e64. https://doi.org/10.1016/j.cels.2016.11.006
doi: 10.1016/j.cels.2016.11.006
pubmed: 27989508
Simpson IA, Carruthers A, Vannucci SJ (2007) Supply and demand in cerebral energy metabolism: the role of nutrient transporters. J Cereb Blood Flow Metab 27:1766–1791. https://doi.org/10.1038/sj.jcbfm.9600521
doi: 10.1038/sj.jcbfm.9600521
pubmed: 17579656
Sims JR, Zimmer JA, Evans CD, Lu M, Ardayfio P, Sparks J et al (2023) Donanemab in early symptomatic alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial. JAMA 330:512–527. https://doi.org/10.1001/jama.2023.13239
doi: 10.1001/jama.2023.13239
pubmed: 37459141
pmcid: 10352931
Situ M, Citalan-Madrid AF, Stamatovic SM, Keep RF, Andjelkovic AV (2022) Transcriptomic profile of blood-brain barrier remodeling in cerebral amyloid angiopathy. Front Cell Neurosci 16:931247. https://doi.org/10.3389/fncel.2022.931247
doi: 10.3389/fncel.2022.931247
pubmed: 35813502
pmcid: 9257207
Skariah G, Todd PK (2021) Translational control in aging and neurodegeneration. Wiley Interdiscip Rev RNA 12:e1628. https://doi.org/10.1002/wrna.1628
doi: 10.1002/wrna.1628
pubmed: 32954679
Stern WM, Sander JW, Rothwell JC, Sisodiya SM (2017) Impaired intracortical inhibition demonstrated in vivo in people with Dravet syndrome. Neurology 88:1659–1665. https://doi.org/10.1212/WNL.0000000000003868
doi: 10.1212/WNL.0000000000003868
pubmed: 28356460
pmcid: 5405762
Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV (2018) The role of brain vasculature in neurodegenerative disorders. Nat Neurosci 21:1318–1331. https://doi.org/10.1038/s41593-018-0234-x
doi: 10.1038/s41593-018-0234-x
pubmed: 30250261
pmcid: 6198802
Tan C, Lu NN, Wang CK, Chen DY, Sun NH, Lyu H et al (2019) Endothelium-derived semaphorin 3G regulates hippocampal synaptic structure and plasticity via neuropilin-2/plexinA4. Neuron 101:920-937.e913. https://doi.org/10.1016/j.neuron.2018.12.036
doi: 10.1016/j.neuron.2018.12.036
pubmed: 30685224
Taniguchi M, Masuda T, Fukaya M, Kataoka H, Mishina M, Yaginuma H et al (2005) Identification and characterization of a novel member of murine semaphorin family. Genes Cells 10:785–792. https://doi.org/10.1111/j.1365-2443.2005.00877.x
doi: 10.1111/j.1365-2443.2005.00877.x
pubmed: 16098142
Thierry M, Ponce J, Martà-Ariza M, Askenazi M, Faustin A, Leitner D et al (2024) The influence of APOE. Acta Neuropathol 147:91. https://doi.org/10.1007/s00401-024-02744-8
doi: 10.1007/s00401-024-02744-8
pubmed: 38772917
pmcid: 11108952
Thomsen MS, Routhe LJ, Moos T (2017) The vascular basement membrane in the healthy and pathological brain. J Cereb Blood Flow Metab 37:3300–3317. https://doi.org/10.1177/0271678X17722436
doi: 10.1177/0271678X17722436
pubmed: 28753105
pmcid: 5624399
Trimm E, Red-Horse K (2023) Vascular endothelial cell development and diversity. Nat Rev Cardiol 20:197–210. https://doi.org/10.1038/s41569-022-00770-1
doi: 10.1038/s41569-022-00770-1
pubmed: 36198871
Tyanova S, Temu T, Sinitcyn P, Carlson A, Hein MY, Geiger T et al (2016) The Perseus computational platform for comprehensive analysis of (prote)omics data. Nat Methods 13:731–740. https://doi.org/10.1038/nmeth.3901
doi: 10.1038/nmeth.3901
pubmed: 27348712
van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M et al (2023) Lecanemab in early Alzheimer’s disease. N Engl J Med 388:9–21. https://doi.org/10.1056/NEJMoa2212948
doi: 10.1056/NEJMoa2212948
pubmed: 36449413
Vervuurt M, Schrader JM, de Kort AM, Kersten I, Wessels HJCT, Klijn CJM et al (2024) Cerebrospinal fluid shotgun proteomics identifies distinct proteomic patterns in cerebral amyloid angiopathy rodent models and human patients. Acta Neuropathol Commun 12:6. https://doi.org/10.1186/s40478-023-01698-4
doi: 10.1186/s40478-023-01698-4
pubmed: 38191511
pmcid: 10775534
Weber SA, Patel RK, Lutsep HL (2018) Cerebral amyloid angiopathy: diagnosis and potential therapies. Expert Rev Neurother 18:503–513. https://doi.org/10.1080/14737175.2018.1480938
doi: 10.1080/14737175.2018.1480938
pubmed: 29792540
Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I et al (2022) A single-cell atlas of the normal and malformed human brain vasculature. Science 375:eabi7377. https://doi.org/10.1126/science.abi7377
doi: 10.1126/science.abi7377
pubmed: 35084939
pmcid: 8995178
Wojtas AM, Dammer EB, Guo Q, Ping L, Shantaraman A, Duong DM et al (2024) Proteomic changes in the human cerebrovasculature in Alzheimer’s disease and related tauopathies linked to peripheral biomarkers in plasma and cerebrospinal fluid. medRxiv. https://doi.org/10.1101/2024.01.10.24301099
doi: 10.1101/2024.01.10.24301099
pubmed: 38260316
pmcid: 10802758
Xiong F, Ge W, Ma C (2019) Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer’s disease. Alzheimers Dement 15:429–440. https://doi.org/10.1016/j.jalz.2018.10.006
doi: 10.1016/j.jalz.2018.10.006
pubmed: 30502339
Yamazaki Y, Shinohara M, Yamazaki A, Murray ME, Liesinger AM, Heckman MG et al (2019) Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression. Brain 142:1077–1092. https://doi.org/10.1093/brain/awz011
doi: 10.1093/brain/awz011
pubmed: 30770921
pmcid: 6439325
Zellner A, Müller SA, Lindner B, Beaufort N, Rozemuller AJM, Arzberger T et al (2022) Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates. Acta Neuropathol Commun 10:6. https://doi.org/10.1186/s40478-021-01303-6
doi: 10.1186/s40478-021-01303-6
pubmed: 35074002
pmcid: 8785498
Zenaro E, Piacentino G, Constantin G (2017) The blood-brain barrier in Alzheimer’s disease. Neurobiol Dis 107:41–56. https://doi.org/10.1016/j.nbd.2016.07.007
doi: 10.1016/j.nbd.2016.07.007
pubmed: 27425887
pmcid: 5600438