A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System.
Differentiation
Heterogeneity
Migration
Myelin-independent roles
OPC-neuron synapse
Oligodendrocyte precursor cell
Proliferation
Journal
Neuroscience bulletin
ISSN: 1995-8218
Titre abrégé: Neurosci Bull
Pays: Singapore
ID NLM: 101256850
Informations de publication
Date de publication:
23 Jul 2024
23 Jul 2024
Historique:
received:
06
11
2023
accepted:
21
03
2024
medline:
23
7
2024
pubmed:
23
7
2024
entrez:
23
7
2024
Statut:
aheadofprint
Résumé
Oligodendrocyte precursor cells (OPCs) are a heterogeneous multipotent population in the central nervous system (CNS) that appear during embryogenesis and persist as resident cells in the adult brain parenchyma. OPCs could generate oligodendrocytes to participate in myelination. Recent advances have renewed our knowledge of OPC biology by discovering novel markers of oligodendroglial cells, the myelin-independent roles of OPCs, and the regulatory mechanism of OPC development. In this review, we will explore the updated knowledge on OPC identity, their multifaceted roles in the CNS in health and diseases, as well as the regulatory mechanisms that are involved in their developmental stages, which hopefully would contribute to a further understanding of OPCs and attract attention in the field of OPC biology.
Identifiants
pubmed: 39042298
doi: 10.1007/s12264-024-01261-8
pii: 10.1007/s12264-024-01261-8
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences.
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