A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System.

Differentiation Heterogeneity Migration Myelin-independent roles OPC-neuron synapse Oligodendrocyte precursor cell Proliferation

Journal

Neuroscience bulletin
ISSN: 1995-8218
Titre abrégé: Neurosci Bull
Pays: Singapore
ID NLM: 101256850

Informations de publication

Date de publication:
23 Jul 2024
Historique:
received: 06 11 2023
accepted: 21 03 2024
medline: 23 7 2024
pubmed: 23 7 2024
entrez: 23 7 2024
Statut: aheadofprint

Résumé

Oligodendrocyte precursor cells (OPCs) are a heterogeneous multipotent population in the central nervous system (CNS) that appear during embryogenesis and persist as resident cells in the adult brain parenchyma. OPCs could generate oligodendrocytes to participate in myelination. Recent advances have renewed our knowledge of OPC biology by discovering novel markers of oligodendroglial cells, the myelin-independent roles of OPCs, and the regulatory mechanism of OPC development. In this review, we will explore the updated knowledge on OPC identity, their multifaceted roles in the CNS in health and diseases, as well as the regulatory mechanisms that are involved in their developmental stages, which hopefully would contribute to a further understanding of OPCs and attract attention in the field of OPC biology.

Identifiants

pubmed: 39042298
doi: 10.1007/s12264-024-01261-8
pii: 10.1007/s12264-024-01261-8
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences.

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Auteurs

Zexuan Ma (Z)

Department of Histology and Embryology, College of basic medicine, Third Military Medical University, Chongqing, 400038, China.

Wei Zhang (W)

Department of Histology and Embryology, College of basic medicine, Third Military Medical University, Chongqing, 400038, China.

Chenmeng Wang (C)

Department of Histology and Embryology, College of basic medicine, Third Military Medical University, Chongqing, 400038, China.
Research Centre, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, China.

Yixun Su (Y)

Research Centre, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, China.

Chenju Yi (C)

Research Centre, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, China. yichj@mail.sysu.edu.cn.
Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, China. yichj@mail.sysu.edu.cn.
Shenzhen Key Laboratory of Chinese Medicine Active substance screening and Translational Research, Shenzhen, 518107, China. yichj@mail.sysu.edu.cn.

Jianqin Niu (J)

Department of Histology and Embryology, College of basic medicine, Third Military Medical University, Chongqing, 400038, China. jianqinniu@tmmu.edu.cn.
Chongqing Key Laboratory of Neurobiology, Chongqing, 400038, China. jianqinniu@tmmu.edu.cn.

Classifications MeSH