Sex differences in choroidal vessels using novel wide-field choroidal en-face images from optical coherence tomography.
Choroidal thickness
Choroidal vessels
En-face imaging
Optical coherence tomography
Vessel density
Wide-field Imaging
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 Jul 2024
23 Jul 2024
Historique:
received:
05
04
2024
accepted:
15
07
2024
medline:
24
7
2024
pubmed:
24
7
2024
entrez:
23
7
2024
Statut:
epublish
Résumé
This study aims to develop a method to quantify choroidal vessels in normal eyes using wide-field optical coherence tomography (OCT) en-face images. The study included participants with normal eyes in whom wide-angle OCT images were acquired to generate planarized choroidal en-face and thickness map images. The images were segmented into central, midperipheral, and peripheral areas, and the midperipheral and peripheral areas were further segmented into supratemporal, infratemporal, supranasal, and infranasal sectors. The mean planarized choroidal-vessel density (p-CVD), planarized choroidal-vessel size (p-CVS), and choroidal thickness (CT) were calculated in each sector. Sex differences were analyzed using the Mann-Whitney U test. The study included 162 participants comprising 84 female (mean age, 43.5 years; axial length, 24.0 mm) and 78 male (mean age, 44.4 years; axial length, 24.2 mm) participants with no significant differences in demographics (P ≥ 0.107). Men had a higher mean p-CVD in all regions (P < 0.001). The mean p-CVS was greater in men in all regions except for the supratemporal sector (P < 0.001). No significant differences in sex in the mean CT were observed in all regions (P ≥ 0.106). The p-CVD and p-CVS in normal eyes differ between sexes. This finding may contribute to the understanding of the pathophysiology of choroidal diseases.
Identifiants
pubmed: 39043834
doi: 10.1038/s41598-024-67671-w
pii: 10.1038/s41598-024-67671-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17013Subventions
Organisme : Japan Society for the Promotion of Science
ID : 21H03095
Informations de copyright
© 2024. The Author(s).
Références
Castro-Correia, J. Understanding the choroid. Inter. Ophthalmol. 19, 135–147 (1995).
doi: 10.1007/BF00133730
Nickla, D. L. & Wallman, J. The multifunctional choroid. Prog. Retin. Eye Res. 29, 144–168 (2010).
doi: 10.1016/j.preteyeres.2009.12.002
pubmed: 20044062
Spaide, R. F. et al. Indocyanine green videoangiography of older patients with central serous chorioretinopathy. Retina 16, 203–213 (1996).
doi: 10.1097/00006982-199616030-00004
pubmed: 8789858
Pang, C. E. & Freund, K. B. Pachychoroid neovasculopathy. Retina 35, 1–9 (2015).
doi: 10.1097/IAE.0000000000000331
pubmed: 25158945
Cheung, C. M. G. et al. Pachychoroid disease. Eye 33, 14–33 (2019).
doi: 10.1038/s41433-018-0158-4
pubmed: 29995841
Spaide, R. F. et al. Venous overload choroidopathy: A hypothetical framework for central serous chorioretinopathy and allied disorders. Prog. Retin. Eye Res. 86, 100973 (2022).
doi: 10.1016/j.preteyeres.2021.100973
pubmed: 34029721
Kitzmann, A. S. et al. The incidence of central serous chorioretinopathy in Olmsted county, Minnesota, 1980–2002. Ophthalmology 115, 169–173 (2008).
doi: 10.1016/j.ophtha.2007.02.032
pubmed: 18166410
Song, Y. et al. Patterns and determinants of choroidal thickness in a multiethnic asian population: The singapore epidemiology of eye diseases study. Ophthalmol. Retina 5, 458–467 (2021).
doi: 10.1016/j.oret.2020.08.012
pubmed: 32858246
Gupta, P. et al. Distribution and determinants of choroidal thickness and volume using automated segmentation software in a population-based study. Am. J. Ophthalmol. 159, 293-301.e3 (2015).
doi: 10.1016/j.ajo.2014.10.034
pubmed: 25447120
Mori, Y. et al. Distribution of choroidal thickness and choroidal vessel dilation in healthy Japanese individuals: The nagahama study. Ophthalmol. Sci. 1, 100033 (2021).
doi: 10.1016/j.xops.2021.100033
pubmed: 36249300
pmcid: 9562294
Li, X. Q., Larsen, M. & Munch, I. C. Subfoveal choroidal thickness in relation to sex and axial length in 93 danish university students. Invest. Ophthalmol. Vis. Sci. 52, 8438–8441 (2011).
doi: 10.1167/iovs.11-8108
pubmed: 21917938
Ding, X. et al. Choroidal thickness in healthy Chinese subjects. Invest. Ophthalmol. Vis. Sci. 52, 9555–9560 (2011).
doi: 10.1167/iovs.11-8076
pubmed: 22058342
Akhtar, Z. et al. Choroidal thickness in normal Indian subjects using swept source optical coherence tomography. PLoS ONE 13, e0197457 (2018).
doi: 10.1371/journal.pone.0197457
pubmed: 29768485
pmcid: 5955571
Funatsu, R. et al. Normal peripheral choroidal thickness measured by widefield optical coherence tomography. Retina 43, 490–497 (2023).
doi: 10.1097/IAE.0000000000003685
pubmed: 36735890
Wei, W. B. et al. Subfoveal choroidal thickness: The Beijing eye study. Ophthalmology 120, 175–180 (2013).
doi: 10.1016/j.ophtha.2012.07.048
pubmed: 23009895
Rasheed, M. A. et al. Wide-field choroidal thickness profile in healthy eyes. Sci. Rep. 8, 17166 (2018).
doi: 10.1038/s41598-018-35640-9
pubmed: 30464195
pmcid: 6249207
Agrawal, R. et al. Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study. Sci. Rep. 6, 21090 (2016).
doi: 10.1038/srep21090
pubmed: 26868048
pmcid: 4751574
Sonoda, S. et al. Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images. Am. J. Ophthalmol. 159, 1123-1131.e1 (2015).
doi: 10.1016/j.ajo.2015.03.005
pubmed: 25790737
Touhami, S. et al. Topographic variations of choroidal thickness in healthy eyes on swept-source optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 61, 38 (2020).
doi: 10.1167/iovs.61.3.38
pubmed: 32196096
pmcid: 7401446
Hirano, M. et al. Analysis of widefield choroidal thickness maps of healthy eyes using swept source optical coherence tomography. Sci. Rep. 13, 11904 (2023).
doi: 10.1038/s41598-023-38845-9
pubmed: 37488140
pmcid: 10366186
Ramtohul, P., Cabral, D., Oh, D., Galhoz, D. & Freund, K. B. En face ultrawidefield OCT of the vortex vein system in central serous chorioretinopathy. Ophthalmol. Retina 7, 346–353 (2023).
doi: 10.1016/j.oret.2022.10.001
pubmed: 36228952
Shiihara, H. et al. Running pattern of choroidal vessel in en face OCT images determined by machine learning-based quantitative method. Graefes Arch. Clin. Exp. Ophthalmol. 257, 1879–1887 (2019).
doi: 10.1007/s00417-019-04399-8
pubmed: 31236669
Kogo, T. et al. Widefield choroidal vasculature associated with future condition of subretinal fluid in central serous chorioretinopathy. Heliyon 9, e18441 (2023).
doi: 10.1016/j.heliyon.2023.e18441
pubmed: 37576325
pmcid: 10412906
Kawano, H. et al. Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-koyanagi-harada disease after treatment. Graefes Arch. Clin. Exp. Ophthalmol. 254, 421–426 (2016).
doi: 10.1007/s00417-016-3283-4
pubmed: 26847039
Funatsu, R. et al. Quantitative evaluations of vortex vein ampullae by adjusted 3D reverse projection model of ultra-widefield fundus images. Sci. Rep. 11, 8916 (2021).
doi: 10.1038/s41598-021-88265-w
pubmed: 33903616
pmcid: 8076294
Yamashita, T. et al. Factors in color fundus photographs that can be used by humans to determine sex of individuals. Transl. Vis. Sci. Tech. 9, 4 (2020).
doi: 10.1167/tvst.9.2.4
Lee, A., Ra, H. & Baek, J. Choroidal vascular densities of macular disease on ultra-widefield indocyanine green angiography. Graefes Arch. Clin. Exp. Ophthalmol. 258, 1921–1929 (2020).
doi: 10.1007/s00417-020-04772-y
pubmed: 32494872
Ulaş, F., Çelik, F., Doğan, Ü. & Çelebi, S. Effect of smoking on choroidal thickness in healthy smokers. Curr. Eye Res. 39, 504–511 (2014).
doi: 10.3109/02713683.2013.850099
pubmed: 24215308
Vural, A. D., Kara, N., Sayin, N., Pirhan, D. & Ersan, H. B. Choroidal thickness changes after a single administration of coffee in healthy subjects. Retina 34, 1223–1228 (2014).
doi: 10.1097/IAE.0000000000000043
pubmed: 24263469
Tan, C. S., Ouyang, Y., Ruiz, H. & Sadda, S. R. Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 53, 261–266 (2012).
doi: 10.1167/iovs.11-8782
pubmed: 22167095
Sonoda, S. et al. Semi-automated software to measure luminal and stromal areas of choroid in optical coherence tomographic images. Jpn. J. Ophthalmol. 62, 179–185 (2018).
doi: 10.1007/s10384-017-0558-1
pubmed: 29270813