Comparative membrane proteomic analysis of Tritrichomonas foetus isolates.
Tritrichomonas foetus
/ isolation & purification
Proteomics
/ methods
Protozoan Proteins
/ metabolism
Animals
Proteome
/ analysis
Cell Membrane
/ metabolism
Cattle
Membrane Proteins
/ metabolism
Cattle Diseases
/ parasitology
Protozoan Infections, Animal
/ parasitology
Computational Biology
/ methods
Tritrichomonas foetus isolates
Diagnosis
Membrane proteins
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 Jul 2024
24 Jul 2024
Historique:
received:
17
03
2024
accepted:
16
07
2024
medline:
24
7
2024
pubmed:
24
7
2024
entrez:
23
7
2024
Statut:
epublish
Résumé
Tritrichomonas foetus is a flagellated and anaerobic parasite able to infect cattle and felines. Despite its prevalence, there is no effective standardized or legal treatment for T. foetus-infected cattle; the vaccination still has limited success in mitigating infections and reducing abortion risk; and nowadays, the diagnosis of T. foetus presents important limitations in terms of sensitivity and specificity in bovines. Here, we characterize the plasma membrane proteome of T. foetus and identify proteins that are represented in different isolates of this protozoan. Additionally, we performed a bioinformatic analysis that revealed the antigenicity potential of some of those proteins. This analysis is the first study to identify common proteins at the plasma membrane of different T. foetus isolates that could be targets for alternative diagnostic or vaccine techniques in the future.
Identifiants
pubmed: 39043862
doi: 10.1038/s41598-024-67827-8
pii: 10.1038/s41598-024-67827-8
doi:
Substances chimiques
Protozoan Proteins
0
Proteome
0
Membrane Proteins
0
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
17033Informations de copyright
© 2024. The Author(s).
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