The causal relationship between inflammatory bowel diseases and erythema nodosum: a bidirectional two-sample mendelian randomization study.

Erythema Nodosum / genetics Humans Mendelian Randomization Analysis Colitis, Ulcerative / genetics Crohn Disease / genetics Inflammatory Bowel Diseases / genetics Causality Polymorphism, Single Nucleotide Genetic Predisposition to Disease Risk Factors
Crohn’s disease Erythema nodosum Inflammatory bowel diseases Mendelian randomization Ulcerative colitis

Journal

BMC gastroenterology
ISSN: 1471-230X
Titre abrégé: BMC Gastroenterol
Pays: England
ID NLM: 100968547

Informations de publication

Date de publication:
23 Jul 2024
Historique:
received: 22 02 2024
accepted: 17 07 2024
medline: 24 7 2024
pubmed: 24 7 2024
entrez: 23 7 2024
Statut: epublish

Résumé

Individuals with inflammatory bowel disease (IBD) exhibit a heightened likelihood of developing erythema nodosum (EN), but the presence of causal link is unknown. The purpose of the present research was to investigate this connection using a bidirectional two-sample Mendelian randomization (MR) analysis. Summarized statistics for EN were sourced from the FinnGen consortium of European ancestry. The International Inflammatory Bowel Disease Genetic Consortium (IBDGC) was used to extract summary data for IBD. The inverse variance weighted (IVW) technique was the major method used to determine the causative link between them. The study evaluated the reciprocal causal link between IBD and EN. The IVW technique confirmed a positive causal link between IBD and EN (OR = 1.237, 95% CI: 1.109-1.37, p = 1.43 × 10 This investigation confirmed that IBD and CD had a causal connection with EN, whereas UC did not. In addition, EN may decrease the likelihood of UC. Further study must be performed to uncover the underlying pathophysiological mechanisms producing that connection.

Sections du résumé

BACKGROUND BACKGROUND
Individuals with inflammatory bowel disease (IBD) exhibit a heightened likelihood of developing erythema nodosum (EN), but the presence of causal link is unknown. The purpose of the present research was to investigate this connection using a bidirectional two-sample Mendelian randomization (MR) analysis.
METHODS METHODS
Summarized statistics for EN were sourced from the FinnGen consortium of European ancestry. The International Inflammatory Bowel Disease Genetic Consortium (IBDGC) was used to extract summary data for IBD. The inverse variance weighted (IVW) technique was the major method used to determine the causative link between them.
RESULTS RESULTS
The study evaluated the reciprocal causal link between IBD and EN. The IVW technique confirmed a positive causal link between IBD and EN (OR = 1.237, 95% CI: 1.109-1.37, p = 1.43 × 10
CONCLUSION CONCLUSIONS
This investigation confirmed that IBD and CD had a causal connection with EN, whereas UC did not. In addition, EN may decrease the likelihood of UC. Further study must be performed to uncover the underlying pathophysiological mechanisms producing that connection.

Identifiants

DOI: 10.1186/s12876-024-03330-8 PMID: 39044191
pubmed: 39044191
doi: 10.1186/s12876-024-03330-8
pii: 10.1186/s12876-024-03330-8
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

231

Subventions

Organisme : National Natural Science Foundation of China
ID : 82070560
Organisme : 1.3.5 Project for Disiplines of Excellence, West China Hospital, Sichuan University
ID : ZYGD23013

Informations de copyright

© 2024. The Author(s).

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Auteurs

Min Zhong (M)

Department of Gastroenterology and the Center of Inflammatory Bowel Disease, West China Hospital, Sichuan University, 37 Guoxue Road, Wuhou District, Chengdu, 332001, Sichuan, China.

Hongjin An (H)

Department of Gastroenterology and the Center of Inflammatory Bowel Disease, West China Hospital, Sichuan University, 37 Guoxue Road, Wuhou District, Chengdu, 332001, Sichuan, China.

Huatian Gan (H)

Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. ganhuatian123@163.com.
Department of Gastroenterology and Laboratory of Inflammatory Bowel Disease, the Center for Inflammatory Bowel Disease, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital , Sichuan University, Chengdu, China. ganhuatian123@163.com.

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questionsmedicales.fr › Troubles dus à des produits chimiques › Effets secondaires indésirables des médicaments › Hypersensibilité médicamenteuse › Toxidermies › Érythème noueux › The causal relationship between inflammatory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The causal relationship between inflammatory...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › The causal relationship between inflammatory...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Rectocolite hémorragique › The causal relationship between inflammatory...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Maladie de Crohn › The causal relationship between inflammatory...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › The causal relationship between inflammatory...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Causalité › The causal relationship between inflammatory...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › The causal relationship between inflammatory...
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questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › The causal relationship between inflammatory...