The Impact of the Fungal Priority Pathogens List on Medical Mycology: A Northern European Perspective.

WHO fungal priority pathogen list fungal diagnostics fungal surveillance mycology

Journal

Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045

Informations de publication

Date de publication:
Jul 2024
Historique:
received: 01 03 2024
accepted: 28 06 2024
medline: 24 7 2024
pubmed: 24 7 2024
entrez: 24 7 2024
Statut: epublish

Résumé

Fungal diseases represent a considerable global health concern, affecting >1 billion people annually. In response to this growing challenge, the World Health Organization introduced the pivotal fungal priority pathogens list (FPPL) in late 2022. The FPPL highlights the challenges in estimating the global burden of fungal diseases and antifungal resistance (AFR), as well as limited surveillance capabilities and lack of routine AFR testing. Furthermore, training programs should incorporate sufficient information on fungal diseases, necessitating global advocacy to educate health care professionals and scientists. Established international guidelines and the FPPL are vital in strengthening local guidance on tackling fungal diseases. Future iterations of the FPPL have the potential to refine the list further, addressing its limitations and advancing our collective ability to combat fungal diseases effectively. Napp Pharmaceuticals Limited (Mundipharma UK) organized a workshop with key experts from Northern Europe to discuss the impact of the FPPL on regional clinical practice.

Identifiants

pubmed: 39045012
doi: 10.1093/ofid/ofae372
pii: ofae372
pmc: PMC11263880
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

ofae372

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Déclaration de conflit d'intérêts

Potential conflicts of interest. M.C.A. has, over the past 5 years, received research grants/contract work (paid to the Statens Serum Institute) from Cidara, F2G, Gilead, and Scynexis and speaker honoraria (personal fees) from Astellas, Chiesi, Gilead, and F2G; she is also the current Chair of EUCAST-AFST. D.A.J. has share options in pulmocide. A.B. has no conflicts of interest. D.D. holds founder shares in F2G Ltd., an antifungal discovery company spun out from the University of Manchester, and share options in TFF Pharma; acts or has recently acted as a consultant to Biosergen, Lifemine Therapeutics, Mucpharm PTY, Pulmatrix, Pulmocide, Rostra Therapeutics, and TFF Pharmaceuticals; has received payments for talks on behalf of Avir, Basilea, BioRad, Gilead, Mundipharma, and Pfizer in the past 3 years; and has been involved in multiple guideline groups, primarily focused on diagnostics and aspergillosis. M.F. has received speaker fees and funding from Gilead Scientific and received funding from the Leverhulme Trust and the Welcome Trust. R.G. has no conflicts of interest. J.M. reports support consulting fees from Amplyx, Basilea, Cidara, F2G, Gilead, Mundipharma, Pfizer, Scynexis, and Takeda; honoraria for lectures from Astellas, Basilea, Gilead, MedScape, Mundipharma, Pfizer, Shionogi, and Takeda; payment for expert testimony from Cidara; and participation on advisory boards with Basilea, Cidara, Pulmocide, Sfunga, and Shionogi. I.M.L. has received lecturer honoraria and has participated on advisory boards with Accelerate, bioMérieux, Biotest, Clinigen, Fresenius Kabi, Gilead, MSD, Mundipharma, Polyphor, and ThermoFisher. V.M. has received speaker honoraria and participated on advisory boards and received research funding from different industry partners including Gilead, Pfizer, Mundipharma, MSD, Novartis, Jazz Pharma, Therakos, Sanofi. T.M. reports consultancy fees from AstraZeneca, Gilead Sciences, Pfizer, and Roche; research grants from Gilead Sciences; and travel support from AstraZeneca, Amgen, and Pfizer. J.P. has given a presentation for Pfizer. R.R. has received lecturer honoraria from Astellas, Mundipharma, Basilea, Gilead, and Pfizer and has participated as a clinical investigator for a Phase 2 clinical trial conducted by Scynexis and as a principal investigator for a Phase 2 clinical trial conducted by F2G. R.W. has no conflicts of interest. N.A. works at Napp Pharmaceuticals Ltd. which is a member of the Mundipharma network of independent associated companies. L.W. performed diagnostic evaluations and received meeting sponsorship from Associates of Cape Cod, Bruker, Dynamiker, and Launch Diagnostics; speaker's fees, expert advice fees, and meeting sponsorship from Gilead; speaker and expert advice fees from Pfizer and Mundipharma; and expert advice fees from F2G.

Auteurs

Maiken Cavling Arendrup (MC)

Unit of Mycology, Statens Serum Institut, Copenhagen, Denmark.
Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Darius Armstrong-James (D)

Department of Infectious Disease, Imperial College London, London, UK.

Andrew M Borman (AM)

Mycology Reference Laboratory, UK Health Security Agency, Bristol, UK.
Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK.

David W Denning (DW)

Manchester Fungal Infection Group, The University of Manchester, Manchester, UK.
Global Action For Fungal Infections, Geneva, Switzerland.

Matthew C Fisher (MC)

MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.

Rebecca Gorton (R)

Department of Infection Sciences, Health Services Laboratories, London, UK.

Johan Maertens (J)

Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium.

Ignacio Martin-Loeches (I)

Department of Intensive Care Medicine, St. James's Hospital, Dublin, Ireland.
Hospital Clinic, IDIBAPS, Universidad de Barcelona, Spain.
CIBERes, Barcelona, Spain.

Varun Mehra (V)

Department of Haematological Medicine, Kings College Hospital NHS Foundation Trust, London, UK.

Toine Mercier (T)

Department of Oncology-Hematology, AZ Sint-Maarten, Mechelen, Belgium.
Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.
Department of Hematology, University Hospitals Leuven, Leuven, Belgium.

Jessica Price (J)

Public Health Wales Mycology Reference Laboratory, UHW, Cardiff, UK.

Riina Rautemaa-Richardson (R)

Department of Infectious Diseases, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.
Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, NIHR Manchester Biomedical Research Centre (BRC) at the Manchester Academic Health Science Centre, The University of Manchester and Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.
Mycology Reference Centre Manchester (MRCM), ECMM Excellence Centre of Medical Mycology, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK.

Rachel Wake (R)

Institute for Infection and Immunity, St George's University of London, London, UK.

Natalie Andrews (N)

Napp Pharmaceuticals Limited, a member of the Mundipharma network of independent associated companies, Cambridge, UK.

P Lewis White (PL)

Public Health Wales Mycology Reference Laboratory, UHW, Cardiff, UK.

Classifications MeSH