Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease.

Cerebral cortex GABAergic signaling Hippocampus Purinergic signaling

Journal

Purinergic signalling
ISSN: 1573-9546
Titre abrégé: Purinergic Signal
Pays: Netherlands
ID NLM: 101250499

Informations de publication

Date de publication:
24 Jul 2024
Historique:
received: 28 02 2024
accepted: 19 06 2024
medline: 24 7 2024
pubmed: 24 7 2024
entrez: 24 7 2024
Statut: aheadofprint

Résumé

Purinergic receptors regulate the processing of neural information in the hippocampus and cerebral cortex, structures related to cognitive functions. These receptors are activated when astrocytic and neuronal populations release adenosine triphosphate (ATP) in an autocrine and paracrine manner, following sustained patterns of neuronal activity. The modulation by these receptors of GABAergic transmission has only recently been studied. Through their ramifications, astrocytes and GABAergic interneurons reach large groups of excitatory pyramidal neurons. Their inhibitory effect establishes different synchronization patterns that determine gamma frequency rhythms, which characterize neural activities related to cognitive processes. During early life, GABAergic-mediated synchronization of excitatory signals directs the experience-driven maturation of cognitive development, and dysfunctions concerning this process have been associated with neurological and neuropsychiatric diseases. Purinergic receptors timely modulate GABAergic control over ongoing neural activity and deeply affect neural processing in the hippocampal and neocortical circuitry. Stimulation of A

Identifiants

pubmed: 39046648
doi: 10.1007/s11302-024-10034-x
pii: 10.1007/s11302-024-10034-x
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2018/07366-4
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2018/07366-4
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2022/00850-3
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2018/07366-4
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2022/00850-3
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 141580/2023-2
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88887.608196/2021-00
Organisme : NSFC-RSF
ID : 82261138557
Organisme : NSFC-RSF
ID : 82261138557
Organisme : NSFC-RSF
ID : 82261138557

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature B.V.

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Auteurs

Guilherme Juvenal (G)

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.

Guilherme Shigueto Vilar Higa (GSV)

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.
Department of Biophysics and Physiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

Lucas Bonfim Marques (L)

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.

Thais Tessari Zampieri (T)

Department of Biophysics and Physiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

Felipe José Costa Viana (FJ)

Department of Biophysics and Physiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

Luiz R Britto (LR)

Department of Biophysics and Physiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

Yong Tang (Y)

International Joint Research Centre On Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.

Peter Illes (P)

International Joint Research Centre On Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Rudolf Boehm Institute for Pharmacology and Toxicology, University of Leipzig, 04107, Leipzig, Germany.

Francesco di Virgilio (F)

Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Henning Ulrich (H)

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil. henning@iq.usp.br.
International Joint Research Centre On Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China. henning@iq.usp.br.

Roberto de Pasquale (R)

Department of Biophysics and Physiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil. robertode@usp.br.

Classifications MeSH