Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease.
Cerebral cortex
GABAergic signaling
Hippocampus
Purinergic signaling
Journal
Purinergic signalling
ISSN: 1573-9546
Titre abrégé: Purinergic Signal
Pays: Netherlands
ID NLM: 101250499
Informations de publication
Date de publication:
24 Jul 2024
24 Jul 2024
Historique:
received:
28
02
2024
accepted:
19
06
2024
medline:
24
7
2024
pubmed:
24
7
2024
entrez:
24
7
2024
Statut:
aheadofprint
Résumé
Purinergic receptors regulate the processing of neural information in the hippocampus and cerebral cortex, structures related to cognitive functions. These receptors are activated when astrocytic and neuronal populations release adenosine triphosphate (ATP) in an autocrine and paracrine manner, following sustained patterns of neuronal activity. The modulation by these receptors of GABAergic transmission has only recently been studied. Through their ramifications, astrocytes and GABAergic interneurons reach large groups of excitatory pyramidal neurons. Their inhibitory effect establishes different synchronization patterns that determine gamma frequency rhythms, which characterize neural activities related to cognitive processes. During early life, GABAergic-mediated synchronization of excitatory signals directs the experience-driven maturation of cognitive development, and dysfunctions concerning this process have been associated with neurological and neuropsychiatric diseases. Purinergic receptors timely modulate GABAergic control over ongoing neural activity and deeply affect neural processing in the hippocampal and neocortical circuitry. Stimulation of A
Identifiants
pubmed: 39046648
doi: 10.1007/s11302-024-10034-x
pii: 10.1007/s11302-024-10034-x
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2018/07366-4
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2018/07366-4
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2022/00850-3
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2018/07366-4
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2022/00850-3
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 141580/2023-2
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88887.608196/2021-00
Organisme : NSFC-RSF
ID : 82261138557
Organisme : NSFC-RSF
ID : 82261138557
Organisme : NSFC-RSF
ID : 82261138557
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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