Koala retrovirus and neoplasia: correlation and underlying mechanisms.

Journal

Current opinion in virology

ISSN: 1879-6265

Titre abrégé: Curr Opin Virol

Pays: Netherlands

ID NLM: 101560941

Informations de publication

Date de publication:
23 Jul 2024

Historique:

received: 01 02 2024

revised: 03 07 2024

accepted: 05 07 2024

medline: 26 7 2024

pubmed: 26 7 2024

entrez: 24 7 2024

Statut: aheadofprint

Résumé

The koala retrovirus, KoRV, is one of the few models for understanding the health consequences of retroviral colonization of the germline. Such colonization events transition exogenous infectious retroviruses to Mendelian traits or endogenous retroviruses (ERVs). KoRV is currently in a transitional state from exogenous retrovirus to ERV, which in koalas (Phascolarctos cinereus) has been associated with strongly elevated levels of neoplasia. In this review, we describe what is currently known about the associations and underlying mechanisms of KoRV-induced neoplasia.

Identifiants

DOI: 10.1016/j.coviro.2024.101427 PMID: 39047314

pubmed: 39047314

pii: S1879-6257(24)00041-5

doi: 10.1016/j.coviro.2024.101427

pii:

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Pagination

101427

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.