Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells.

Treg cells regulatory T cells scATAC-seq tissue adaptation tissue-residing immune cells transposable element

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
17 Jul 2024
Historique:
received: 02 10 2023
revised: 12 03 2024
accepted: 28 06 2024
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 24 7 2024
Statut: aheadofprint

Résumé

Tissue adaptation is required for regulatory T (Treg) cell function within organs. Whether this program shares aspects with other tissue-localized immune populations is unclear. Here, we analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45

Identifiants

DOI: 10.1016/j.immuni.2024.06.015 PMID: 39047731
pubmed: 39047731
pii: S1074-7613(24)00321-2
doi: 10.1016/j.immuni.2024.06.015
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Malte Simon (M)

Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany; Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany; Chair for Immunology, University Regensburg, 93053 Regensburg, Germany.

Philipp Stüve (P)

Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany; Chair for Immunology, University Regensburg, 93053 Regensburg, Germany.

Lisa Schmidleithner (L)

Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany; Chair for Immunology, University Regensburg, 93053 Regensburg, Germany.

Sebastian Bittner (S)

Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany; Chair for Immunology, University Regensburg, 93053 Regensburg, Germany.

Niklas Beumer (N)

Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany; DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, 68167 Mannheim, Germany; Division of Personalized Medical Oncology, DKFZ, 69120 Heidelberg, Germany; Department of Personalized Oncology, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.

Nicholas Strieder (N)

Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany.

Christian Schmidl (C)

Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany.

Asmita Pant (A)

Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany; Chair for Immunology, University Regensburg, 93053 Regensburg, Germany.

Claudia Gebhard (C)

Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany.

Andreas Eigenberger (A)

Department of Plastic, Hand, and Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.

Michael Rehli (M)

Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany; Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany.

Lukas Prantl (L)

Department of Plastic, Hand, and Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.

Thomas Hehlgans (T)

Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany; Chair for Immunology, University Regensburg, 93053 Regensburg, Germany.

Benedikt Brors (B)

Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), DKFZ, 69120 Heidelberg, Germany; Medical Faculty Heidelberg and Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany.

Charles D Imbusch (CD)

Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Michael Delacher (M)

Institute of Immunology, University Medical Center Mainz, 55131 Mainz, Germany; Research Center for Immunotherapy, University Medical Center Mainz, 55131 Mainz, Germany.

Markus Feuerer (M)

Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany; Chair for Immunology, University Regensburg, 93053 Regensburg, Germany. Electronic address: markus.feuerer@ukr.de.

Classifications MeSH