NONO2P, a novel nitric oxide donor, causes vasorelaxation through NO/sGC/PKG pathway, K

NO donor NO-pathway NONO2P cardiovascular effects mesenteric artery vasorelaxant effect

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
22 Jul 2024
Historique:
received: 04 02 2024
revised: 01 07 2024
accepted: 17 07 2024
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 24 7 2024
Statut: aheadofprint

Résumé

The treatment of cardiovascular diseases (CVD) could greatly benefit from using nitric oxide (NO) donors. This study aimed to investigate the mechanisms of action of NONO2P that contribute to the observed responses in the mesenteric artery. The hypothesis was that NONO2P would have similar pharmacological actions to sodium nitroprusside (SNP) and NO. Male Wistar rats were euthanized to isolate the superior mesenteric artery for isometric tension recordings. NO levels were measured using the DAF-FM/DA dye, and cyclic guanosine monophosphate (cGMP) levels were determined using a cGMP-ELISA Kit. NONO2P presented a similar maximum efficacy to SNP. The free radical of NO (NO NONO2P induces vasorelaxation with the same magnitude as SNP, releasing NO

Sections du résumé

BACKGROUND & AIMS OBJECTIVE
The treatment of cardiovascular diseases (CVD) could greatly benefit from using nitric oxide (NO) donors. This study aimed to investigate the mechanisms of action of NONO2P that contribute to the observed responses in the mesenteric artery. The hypothesis was that NONO2P would have similar pharmacological actions to sodium nitroprusside (SNP) and NO.
METHODS METHODS
Male Wistar rats were euthanized to isolate the superior mesenteric artery for isometric tension recordings. NO levels were measured using the DAF-FM/DA dye, and cyclic guanosine monophosphate (cGMP) levels were determined using a cGMP-ELISA Kit.
RESULTS RESULTS
NONO2P presented a similar maximum efficacy to SNP. The free radical of NO (NO
CONCLUSIONS CONCLUSIONS
NONO2P induces vasorelaxation with the same magnitude as SNP, releasing NO

Identifiants

DOI: 10.1016/j.ejphar.2024.176822 PMID: 39047965
pubmed: 39047965
pii: S0014-2999(24)00511-9
doi: 10.1016/j.ejphar.2024.176822
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

176822

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that there are no conflicts of interest.

Auteurs

Raiana A Moraes (RA)

Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.

Daniele S Brito (DS)

Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.

Fênix A Araujo (FA)

Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.

Rafael L C Jesus (RLC)

Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil.

Liliane B Silva (LB)

Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil.

Denise S Sá (DS)

Federal Institute of Bahia, IFBA, Salvador, BA, Brazil.

Carlos D Silva da Silva (CD)

Federal Institute of Bahia, IFBA, Salvador, BA, Brazil.

Laena Pernomian (L)

Department of Cell Biology and Anatomy, University of South Carolina, Columbia, SC, USA; Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC, USA.

Camilla F Wenceslau (CF)

Department of Cell Biology and Anatomy, University of South Carolina, Columbia, SC, USA; Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC, USA.

Fernanda Priviero (F)

Department of Cell Biology and Anatomy, University of South Carolina, Columbia, SC, USA; Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC, USA.

R Clinton Webb (RC)

Department of Cell Biology and Anatomy, University of South Carolina, Columbia, SC, USA; Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC, USA.

Darizy F Silva (DF)

Laboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil. Electronic address: darizy@gmail.com.

Classifications MeSH