Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 Jul 2024
24 Jul 2024
Historique:
received:
20
12
2023
accepted:
19
06
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
24
7
2024
Statut:
epublish
Résumé
Aedes aegypti (yellow fever mosquito) and Ae. albopictus (Asian tiger mosquito) are globally invasive pests that confer the world's dengue burden. Insecticide-based management has led to the evolution of insecticide resistance in both species, though the genetic architecture and geographical spread of resistance remains incompletely understood. This study investigates partial selective sweeps at resistance genes on two chromosomes and characterises their spread across populations. Sweeps at the voltage-sensitive sodium channel (VSSC) gene on chromosome 3 correspond to one resistance-associated nucleotide substitution in Ae. albopictus and three in Ae. aegypti, including two substitutions at the same nucleotide position (F1534C) that have evolved and spread independently. In Ae. aegypti, we also identify partial sweeps at a second locus on chromosome 2. This locus contains 15 glutathione S-transferase (GST) epsilon class genes with significant copy number variation among populations and where three distinct genetic backgrounds have spread across the Indo-Pacific region, the Americas, and Australia. Local geographical patterns and linkage networks indicate VSSC and GST backgrounds probably spread at different times and interact locally with different genes to produce resistance phenotypes. These findings highlight the rapid global spread of resistance and are evidence for the critical importance of GST genes in resistance evolution.
Identifiants
pubmed: 39048545
doi: 10.1038/s41467-024-49792-y
pii: 10.1038/s41467-024-49792-y
doi:
Substances chimiques
Glutathione Transferase
EC 2.5.1.18
Insecticides
0
Voltage-Gated Sodium Channels
0
Insect Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6251Subventions
Organisme : Department of Education and Training | Australian Research Council (ARC)
ID : DE230100257
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : GNT1161627
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 2004390
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : GNT1141441
Organisme : Department of Foreign Affairs and Trade, Australian Government (Department of Foreign Affairs and Trade)
ID : 74430
Informations de copyright
© 2024. The Author(s).
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