Sclerotherapy for the intraoral ranula with bleomycin: technical considerations and preliminary experience.
Bleomycin
Ranula
Sclerotherapy
Sublingual Gland
Journal
BMC oral health
ISSN: 1472-6831
Titre abrégé: BMC Oral Health
Pays: England
ID NLM: 101088684
Informations de publication
Date de publication:
24 Jul 2024
24 Jul 2024
Historique:
received:
17
05
2024
accepted:
18
07
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
epublish
Résumé
Ranula is a mucous cyst that occurs in the sublingual gland (SLG) in the floor of the mouth. It can be classified into two types based on origins: One is the the lesser sublingual gland (LSLG) in the anterior segment and the Rivini duct, which is connected to it, and the other is the greater sublingual gland (GSLG) in the posterior segment. Because of the anatomical characteristics, surgical resection of the cysts carries the risk of damaging adjacent tissues and has a high recurrence rate. Intralesional injection of sclerotherapy may be a better alternative treatment. We summarized 65 cases of ranula treated with intralesional injections of bleomycin(BML). According to the origin of the ranula, 60 cases were from the LSLG and the Rivini duct, and 5 cases were from the GSLG. The results showed that 60 cases of ranula from LSLG and Rivini ducts were 100% cured during the follow-up period. The median number of injections for all patients was 1.16. All 5 cases of ranula from the GSLG did not wholly recover. This study confirmed that BLM intralesional injection is a safe and effective treatment modality for cysts from LSLG or the ducts of Rivini rather than GSLG. Therefore, before treatment, it is necessary to determine the type and origin of the cyst by characterizing its morphology to ensure the effectiveness of the treatment.
Identifiants
pubmed: 39048989
doi: 10.1186/s12903-024-04633-8
pii: 10.1186/s12903-024-04633-8
doi:
Substances chimiques
Bleomycin
11056-06-7
Sclerosing Solutions
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
833Subventions
Organisme : the National Natural Science Foundation of China
ID : Grant Nos. 31400836
Informations de copyright
© 2024. The Author(s).
Références
Baurmash HD. Mucoceles and ranulas. J Oral Maxillofac Surg. 2003;61(3):369–78. https://doi.org/10.1053/joms.2003.50074 .
doi: 10.1053/joms.2003.50074
pubmed: 12618979
Kokong D, Iduh A, Chukwu I, Mugu J, Nuhu S, Augustine S. Ranula: Current Concept of Pathophysiologic Basis and Surgical Management Options. World J Surg. 2017;41(6):1476–81. https://doi.org/10.1007/s00268-017-3901-2 .
doi: 10.1007/s00268-017-3901-2
pubmed: 28194490
pmcid: 5422487
Peters E, Kola H, Doyle-Chan W. Bilateral congential oral mucous extravasation cysts. Pediatr Dent. 1999;21:285–8.
pubmed: 10436485
Ghom AG, Ghom SA. Textbook of Oral Medicine. JP Medical Ltd; 2014. Accessed March 29, 2024.
Lee E, Cho SH, Park CJ. Clinical and Immunohistochemical Characteristics of Mucoceles. Ann Dermatol. 2009;21(4):345–51. https://doi.org/10.5021/ad.2009.21.4.345 .
doi: 10.5021/ad.2009.21.4.345
pubmed: 20523822
pmcid: 2861262
Ata-Ali J, Carrillo C, Bonet C, Balaguer J, Penarrocha M. Oral mucocele: Review of the literature. J Clin Exp Dent. 2010;2. https://doi.org/10.4317/jced.2.e18
Hayashida AM, Zerbinatti DC, Balducci I, Cabral LAG, Almeida JD. Mucus extravasation and retention phenomena: a 24-year study. BMC Oral Health. 2010;10(1):15. https://doi.org/10.1186/1472-6831-10-15 .
doi: 10.1186/1472-6831-10-15
pubmed: 20529263
pmcid: 2894742
Rabe E, Breu F, Cavezzi A, et al. European guidelines for sclerotherapy in chronic venous disorders. Phlebol J Venous Dis. 2014;29(6):338–54. https://doi.org/10.1177/0268355513483280 .
doi: 10.1177/0268355513483280
Leppi TJ. Gross Anatomical Relationships Between Primate Submandibular and Sublingual Salivary Glands. J Dent Res. 1967;46(2):359–65. https://doi.org/10.1177/00220345670460020801 .
doi: 10.1177/00220345670460020801
pubmed: 4960427
Thoma KH. A Contribution to the Knowledge of the Development of the Submaxillary and Sublingual Salivary Glands in Human Embryos. J Dent Res. Published online June 1, 1919. https://doi.org/10.1177/00220345190010020501
McGurk M, Combes J, Cascarini L. Controversies in the Management of Salivary Gland Disease. OUP Oxford; 2013.
Re Cecconi D, Achilli A, Tarozzi M, et al. Mucoceles of the oral cavity: A large case series (1994-2008) and a literature review. Med Oral Patol Oral Cirugia Bucal. Published online 2010:e551-e556. https://doi.org/10.4317/medoral.15.e551
Baurmash HD. A Case Against Sublingual Gland Removal as Primary Treatment of Ranulas. J Oral Maxillofac Surg. 2007;65(1):117–21. https://doi.org/10.1016/j.joms.2006.05.006 .
doi: 10.1016/j.joms.2006.05.006
pubmed: 17174775
Harrison JD. Modern management and pathophysiology of ranula: Literature review. Head Neck. 2010;32(10):1310–20. https://doi.org/10.1002/hed.21326 .
doi: 10.1002/hed.21326
pubmed: 20054853
Pandit RT, Park AH. Management of Pediatric Ranula. Otolaryngol Head Neck Surg. 2002;127(1):115–8. https://doi.org/10.1067/mhn.2002.126590 .
doi: 10.1067/mhn.2002.126590
pubmed: 12161740
Botazzo AC, Cunha F. Treatment of mucus retention phenomena in children by the micro-marsuapialization technique: case report. Pediatr Dent. 2000;22(2):155–8.
Sandrini FAL, Sant’Ana-Filho M, Rados PV. Ranula Management: Suggested Modifications in the Micro-Marsupialization Technique. J Oral Maxillofac Surg. 2007;65(7):1436-1438. https://doi.org/10.1016/j.joms.2006.06.291
YagüeGarcía J, EspañaTost AJ, BeriniAytés L, Gay-Escoda C. Treatment of oral mucocele - scalpel versus C02 laser. Med Oral Patol Oral Cir Bucal Ed Inglesa. 2009;14(9):12.
Niccoli-Filho W, Morosolli ARC. Surgical treatment of ranula with carbon dioxide laser radiation. Lasers Med Sci. 2004;19(1):12–4. https://doi.org/10.1007/s10103-004-0293-y .
doi: 10.1007/s10103-004-0293-y
pubmed: 15316853
Bodner L, Tal H. Salivary gland cysts of the oral cavity: clinical observation and surgical management. Compend Newtown Pa. 1991;12(3):150, 152, 154-156.
Baurmash HD. Treating oral ranula: another case against blanket removal of the sublingual gland. Br J Oral Maxillofac Surg. 2001;39(3):217–20. https://doi.org/10.1054/bjom.2000.0606 .
doi: 10.1054/bjom.2000.0606
pubmed: 11384120
McGurk M, Eyeson J, Thomas B, Harrison JD. Conservative Treatment of Oral Ranula by Excision With Minimal Excision of the Sublingual Gland: Histological Support for a Traumatic Etiology. J Oral Maxillofac Surg. 2008;66(10):2050–7. https://doi.org/10.1016/j.joms.2008.01.019 .
doi: 10.1016/j.joms.2008.01.019
pubmed: 18848101
Morton RP. Surgical Management of Ranula Revisited. World J Surg. 2018;42(9):3062–3. https://doi.org/10.1007/s00268-018-4666-y .
doi: 10.1007/s00268-018-4666-y
pubmed: 29750326
Fukase S, Inamura K, Ohta N, Aoyagi M. Treatment of Ranula with Intracystic Injection of the Streptococcal Preparation Ok-432. Ann Otol Rhinol Laryngol. 2003;112(3):214–20. https://doi.org/10.1177/000348940311200304 .
doi: 10.1177/000348940311200304
pubmed: 12656411
Sinha R, Sarkar S, Khaitan T, Kabiraj A, Maji A. Nonsurgical Management of Oral Mucocele by Intralesional Corticosteroid Therapy. Int J Dent. 2016;2016: e2896748. https://doi.org/10.1155/2016/2896748 .
doi: 10.1155/2016/2896748
Cai Y, Wang R, Yang S, Zhao Y, Zhao J. Sclerotherapy for the mucoceles of the anterior lingual salivary glands with pingyangmycin. Oral Dis. 2014;20(5):473–6. https://doi.org/10.1111/odi.12155 .
doi: 10.1111/odi.12155
pubmed: 23848975
Liu J, Zhang A, Jiang L, et al. The efficacy of polidocanol sclerotherapy in mucocele of the minor salivary gland. J Oral Pathol Med. 2018;47(9):895–9. https://doi.org/10.1111/jop.12764 .
doi: 10.1111/jop.12764
pubmed: 29998466
Huang Y, Yang C, Wang T, Liu S, Chen A. Preliminary experience with promethazine hydrochloride injection in the sclerotherapy of oral mucocele. Int J Oral Maxillofac Surg. 2021;50(4):516–21. https://doi.org/10.1016/j.ijom.2020.06.021 .
doi: 10.1016/j.ijom.2020.06.021
pubmed: 32682647
Umezawa, Maeda K, Takeuchi T, et al. New antibiotics, bleomycin A and B. J Antibiot(Tokyo), 1966, 19: 200-209.
Jin L, Chen J, Li X. Surgical Excision With Bleomycin Irrigation: A Better Primary Treatment Choice for Pediatric Submandibular Lymphatic Malformations. J Oral Maxillofac Surg. 2017;75(2):437.e1-437.e7. https://doi.org/10.1016/j.joms.2016.09.041 .
doi: 10.1016/j.joms.2016.09.041
pubmed: 27789267
Li L, Chen CC, Zeng XQ. One-year Results of Single-session Sclerotherapy with Bleomycin in Simple Renal Cysts. J Vasc Interv Radiol. 2012;23(12):1651–6. https://doi.org/10.1016/j.jvir.2012.08.030 .
doi: 10.1016/j.jvir.2012.08.030
pubmed: 23177112
Manna S, Bageac DV, Berenstein A, Sinclair CF, Kirke D, De Leacy R. Bleomycin sclerotherapy following doxycycline lavage in the treatment of ranulas: A retrospective analysis and review of the literature. Neuroradiol J. 2021;34(5):449–55. https://doi.org/10.1177/19714009211008790 .
doi: 10.1177/19714009211008790
pubmed: 33832375
pmcid: 8559021
MacIntosh PW, Yoon MK, Fay A. Complications of Intralesional Bleomycin in the Treatment of Orbital Lymphatic Malformations. Semin Ophthalmol. 2014;29(5–6):450–5. https://doi.org/10.3109/08820538.2014.959617 .
doi: 10.3109/08820538.2014.959617
pubmed: 25325873