Clinical Management and Outcomes of Nontuberculous Mycobacterial Infections in Solid Organ Transplant Recipients: A Multinational Case-control Study.


Journal

Transplantation
ISSN: 1534-6080
Titre abrégé: Transplantation
Pays: United States
ID NLM: 0132144

Informations de publication

Date de publication:
25 Jul 2024
Historique:
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 25 7 2024
Statut: aheadofprint

Résumé

The management and outcomes of nontuberculous mycobacterial (NTM) infections in solid organ transplant (SOT) recipients are poorly characterized. We aimed to describe the management and 1-y mortality of these patients. Retrospective, multinational, 1:2 matched case-control study included SOT recipients aged 12 y old or older diagnosed with NTM infection between January 1, 2008, and December 31, 2018. Controls were matched on transplanted organs, NTM treatment center, and posttransplant survival at least equal to the time to NTM diagnosis. The primary aim was 1-y mortality after NTM diagnosis. Differences between cases and controls were compared using the log-rank test, and Cox regression models were used to identify factors associated with mortality at 12 mo among cases. In 85 patients and 169 controls, the median age at the time of SOT was 54 y (interquartile range, 40-62 y), 59% were men, and the lungs were the most common site of infection after SOT (57.6%). One-year mortality was significantly higher in cases than in controls (20% versus 3%; P < 0.001), and higher mortality was associated with lung transplantation (hazard ratio 3.27; 95% confidence interval [1.1-9.77]; P = 0.034). Median time (interquartile range) from diagnosis to treatment initiation (20 [4-42] versus 11 [3-21] d) or the reduction of net immunosuppression (36% versus 45%, hazard ratio 1.35 [95% CI, 0.41-4.43], P = 0.618) did not differ between survivors and those who died. NTM disease in SOT recipients is associated with a higher mortality risk, especially among lung transplant recipients. Time to NTM treatment and reduction in net immunosuppression were not associated with mortality.

Sections du résumé

BACKGROUND BACKGROUND
The management and outcomes of nontuberculous mycobacterial (NTM) infections in solid organ transplant (SOT) recipients are poorly characterized. We aimed to describe the management and 1-y mortality of these patients.
METHODS METHODS
Retrospective, multinational, 1:2 matched case-control study included SOT recipients aged 12 y old or older diagnosed with NTM infection between January 1, 2008, and December 31, 2018. Controls were matched on transplanted organs, NTM treatment center, and posttransplant survival at least equal to the time to NTM diagnosis. The primary aim was 1-y mortality after NTM diagnosis. Differences between cases and controls were compared using the log-rank test, and Cox regression models were used to identify factors associated with mortality at 12 mo among cases.
RESULTS RESULTS
In 85 patients and 169 controls, the median age at the time of SOT was 54 y (interquartile range, 40-62 y), 59% were men, and the lungs were the most common site of infection after SOT (57.6%). One-year mortality was significantly higher in cases than in controls (20% versus 3%; P < 0.001), and higher mortality was associated with lung transplantation (hazard ratio 3.27; 95% confidence interval [1.1-9.77]; P = 0.034). Median time (interquartile range) from diagnosis to treatment initiation (20 [4-42] versus 11 [3-21] d) or the reduction of net immunosuppression (36% versus 45%, hazard ratio 1.35 [95% CI, 0.41-4.43], P = 0.618) did not differ between survivors and those who died.
CONCLUSIONS CONCLUSIONS
NTM disease in SOT recipients is associated with a higher mortality risk, especially among lung transplant recipients. Time to NTM treatment and reduction in net immunosuppression were not associated with mortality.

Identifiants

pubmed: 39049076
doi: 10.1097/TP.0000000000005156
pii: 00007890-990000000-00830
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : none

Informations de copyright

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

The authors declare no funding or conflicts of interest.

Références

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Auteurs

Francisco López-Medrano (F)

Unit of Infectious Diseases, University Hospital 12 de Octubre, Instituto de Investigación del Hospital 12 de Octubre (imas12), School of Medicine, Universidad Complutense, Madrid, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC; CB21/13/00009), Instituto de Salud Carlos III, Madrid, Spain.

Peggy L Carver (PL)

Department of Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI.

Sasinuch Rutjanawech (S)

Department of Infectious Diseases, Washington University School of Medicine, St. Louis, MO.

Luis F Aranha-Camargo (LF)

Department of Infectious Diseases, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Ruan Fernandes (R)

Department of Infectious Diseases, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Sara Belga (S)

Department of Infectious Diseases, University of British Columbia Faculty of Medicine, Vancouver, BC, Canada.

Shay-Anne Daniels (SA)

Department of Infectious Diseases, University of British Columbia Faculty of Medicine, Vancouver, BC, Canada.

Nicolas J Mueller (NJ)

Department of Infectious Diseases, University Hospital Zurich, Zurich, Switzerland.

Sara Burkhard (S)

Department of Infectious Diseases, University Hospital Zurich, Zurich, Switzerland.

Nicole M Theodoropoulos (NM)

Department of Infectious Diseases, University of Massachusetts Chan Medical School, Worcester, MA.

Douwe F Postma (DF)

Department of Internal Medicine and Infectious Diseases, Groningen, the Netherlands.

Pleun J van Duijn (PJ)

Certe Laboratory for Infectious Diseases, Department of Clinical Microbiology, Groningen, the Netherlands.

Francisco Arnaiz de Las Revillas (F)

Infectious Diseases and Microbiology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Cantabria, Spain.
CIBERINFEC (CB21/13/00068), ISCIII, Madrid, Spain.

Concepción Pérez Del Molino-Bernal (C)

Infectious Diseases and Microbiology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Cantabria, Spain.
CIBERINFEC (CB21/13/00068), ISCIII, Madrid, Spain.

Jonathan Hand (J)

Department of Infectious Diseases, Ochsner Medical Center, New Orleans, LA.

Adam Lowe (A)

Department of Infectious Diseases, Ochsner Medical Center, New Orleans, LA.

Marta Bodro (M)

Department of Infectious Diseases, Hospital Clinic Barcelona, Barcelona, Spain.

Elisa Vanino (E)

Infectious Diseases Unit, IRCCS Policlinico Sant'Orsola, University of Bologna, Bologna, Italy.
Infectious Diseases Unit, Ravenna Hospital, AUSL Romagna, Ravenna, Italy.

Ana Fernández-Cruz (A)

Department of Infectious Diseases, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.

Antonio Ramos-Martínez (A)

Department of Infectious Diseases, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.

Mateja Jankovic Makek (MJ)

Department of Infectious Diseases, School of Medicine, University of Zagreb, University Hospital Center Zagreb, Zagreb, Croatia.

Ribal Bou Mjahed (R)

Department of Infectious Diseases, School of Medicine, University of Zagreb, University Hospital Center Zagreb, Zagreb, Croatia.

Oriol Manuel (O)

Department of Infectious Diseases, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Nassim Kamar (N)

Department of Nephrology and Organs Transplantation, Toulouse Rangueil University, INSERM UMR 1291, Toulouse Institute for Infectious and Inflammatory Disease (Infinity), Paul Sabatier University, Toulouse, France.

Antonia Calvo-Cano (A)

Infectious Disease Department, University Hospital Badajoz, Badajoz, Spain.

Laura Rueda-Carrasco (L)

Infectious Disease Department, University Hospital Badajoz, Badajoz, Spain.

Patricia Muñoz (P)

Departamento de Medicina, Hospital Gregorio Marañón, Biomedical Research Institute Gregorio Marañon (IiSGM), CIBERES, Universidad Complutense, Madrid, Spain.

Ana Álvarez-Uría (A)

Departamento de Medicina, Hospital Gregorio Marañón, Biomedical Research Institute Gregorio Marañon (IiSGM), CIBERES, Universidad Complutense, Madrid, Spain.

Sandra Pérez-Recio (S)

Tuberculosis Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge, Biomedical Research Institute (IDIBELL), University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.

Núria Sabé (N)

Tuberculosis Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge, Biomedical Research Institute (IDIBELL), University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.

Regino Rodríguez-Álvarez (R)

Department of Infectious Diseases, Hospital Universitario Cruces, Barakaldo, Spain.

José Tiago Silva (JT)

Unit of Infectious Diseases, University Hospital 12 de Octubre, Instituto de Investigación del Hospital 12 de Octubre (imas12), School of Medicine, Universidad Complutense, Madrid, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC; CB21/13/00009), Instituto de Salud Carlos III, Madrid, Spain.

Alessandra Mularoni (A)

Department of Infectious Diseases, IRCC-ISMETT, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy.

Elisa Vidal (E)

Department of Infectious Diseases, Reina Sofía University Hospital, Córdoba, Spain.

Juana Alonso-Titos (J)

Department of Nephrology, Hospital Regional Universitario de Málaga, Málaga, Spain.

Teresa Del Rosal (T)

Department of Pediatrics, Hospital Universitario La Paz, Madrid, Spain.

Annika Y Classen (AY)

Department I for Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany.

Charles W Goss (CW)

Department of Infectious Diseases, Washington University School of Medicine, St. Louis, MO.

Mansi Agarwal (M)

Department of Infectious Diseases, Washington University School of Medicine, St. Louis, MO.

Carlos Mejía-Chew (C)

Department of Infectious Diseases, Washington University School of Medicine, St. Louis, MO.

Classifications MeSH