Analysis of major otosclerosis-associated variants in
association study
gene
hearing loss
otosclerosis
polymorphisms
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
2024
2024
Historique:
received:
23
12
2019
accepted:
26
12
2019
medline:
16
9
2020
pubmed:
16
9
2020
entrez:
25
7
2024
Statut:
epublish
Résumé
Otosclerosis (OTSC) is one of the most common causes of progressive adult-onset hearing loss in the Caucasian population, with a female preponderance. The etiology of OTSC is complex and there are a number of genetic variants reported to be associated with OTSC susceptibility, but no data on the genetic background of OTSC in patients originating from the central-eastern part of Europe have been available. The purpose of our study was to investigate in Polish patients the frequency of genetic variants previously reported to be most strongly associated with OTSC. Genomic DNA was isolated from blood samples or buccal swabs. Variants in For all of the tested variants the distributions of alleles and genotypes were not statistically significantly different between OTCS patients and the control group. There were also no statistically significant differences in relation to gender of the tested subjects. Despite multiple confirmatory studies on
Identifiants
pubmed: 39050165
doi: 10.5114/aoms.2020.99011
pii: 115865
pmc: PMC11264066
doi:
Types de publication
Journal Article
Langues
eng
Pagination
962-966Informations de copyright
Copyright: © 2020 Termedia & Banach.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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