Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects.
HPLC
NMR spectroscopy
dihydroquercetin
flavonoid
optical activity
pharmacodynamics
pharmacokinetics
stereoisomerism
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2024
2024
Historique:
received:
27
05
2024
accepted:
11
06
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
epublish
Résumé
Dihydroquercetin (DHQ) is a representative of flavonoids that is available on the market as a food supplement and registered as an active pharmaceutical ingredient. The structure of this compound is characterized by the presence of two chiral centers in positions 2 and 3 of the pyranone ring. Current regulatory documentation on DHQ lacks quantitative analysis of the stereoisomers of this flavanonol. This poses potential risks for consumers of DHQ-based dietary supplements and developers of new drugs. This review was conducted to systematize data on the pharmacology of DHQ stereoisomers and the possible methods of controlling them in promising chiral drugs. We found that relying on literature data of polarimetry for the identification of DHQ stereoisomers is currently impossible due to these heterogeneities. NMR spectroscopy allows to distinguishing between
Identifiants
pubmed: 39050369
doi: 10.3389/fchem.2024.1439167
pii: 1439167
pmc: PMC11267486
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1439167Informations de copyright
Copyright © 2024 Terekhov, Savina, Pankov, Korochkina, Taldaev, Yakubovich, Zavadskiy, Zhevlakova and Selivanova.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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