Decreased free D-aspartate levels in the blood serum of patients with schizophrenia.
D-aspartate
D-serine
antipsychotics
autism spectrum disorder
schizophrenia
treatment-resistant
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2024
2024
Historique:
received:
27
03
2024
accepted:
17
06
2024
medline:
26
7
2024
pubmed:
26
7
2024
entrez:
25
7
2024
Statut:
epublish
Résumé
Schizophrenia (SCZ) and autism spectrum disorder (ASD) are neurodevelopmental diseases characterized by different psychopathological manifestations and divergent clinical trajectories. Various alterations at glutamatergic synapses have been reported in both disorders, including abnormal NMDA and metabotropic receptor signaling. We conducted a bicentric study to assess the blood serum levels of NMDA receptors-related glutamatergic amino acids and their precursors, including L-glutamate, L-glutamine, D-aspartate, L-aspartate, L-asparagine, D-serine, L-serine and glycine, in ASD, SCZ patients and their respective control subjects. Specifically, the SCZ patients were subdivided into treatment-resistant and non-treatment-resistant SCZ patients, based on their responsivity to conventional antipsychotics. D-serine and D-aspartate serum reductions were found in SCZ patients compared to controls. Conversely, no significant differences between cases and controls were found in amino acid concentrations in the two ASD cohorts analyzed. This result further encourages future research to evaluate the predictive role of selected D-amino acids as peripheral markers for SCZ pathophysiology and diagnosis.
Identifiants
pubmed: 39050919
doi: 10.3389/fpsyt.2024.1408175
pmc: PMC11266155
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1408175Informations de copyright
Copyright © 2024 Garofalo, De Simone, Motta, Nuzzo, De Grandis, Bruno, Boeri, Riccio, Pastore, Bravaccio, Iasevoli, Salvatore, Pollegioni, Errico, de Bartolomeis and Usiello.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Références
Invest Clin. 1996 Jun;37(2):113-28
pubmed: 8718922
Schizophr Res. 2012 Dec;142(1-3):83-7
pubmed: 23063707
Amino Acids. 2022 Mar;54(3):421-432
pubmed: 35226151
J Pharm Biomed Anal. 2015 Dec 10;116:7-17
pubmed: 25868730
Neurosci Lett. 2014 Oct 17;582:93-8
pubmed: 25218715
Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2300817120
pubmed: 37014864
Eur J Pharmacol. 2004 Jul 14;495(2-3):153-8
pubmed: 15249164
Schizophr Res. 2018 Feb;192:226-231
pubmed: 28599751
Med Hypotheses. 2011 Dec;77(6):1015-21
pubmed: 21925797
Neuroimaging Clin N Am. 2020 Feb;30(1):97-114
pubmed: 31759576
Clin Neurosci. 1995;3(2):89-97
pubmed: 7583624
PLoS One. 2011;6(10):e25340
pubmed: 21998651
Transl Psychiatry. 2015 Feb 17;5:e512
pubmed: 25689573
J Clin Biochem Nutr. 2012 Nov;51(3):248-9
pubmed: 23170055
Front Psychiatry. 2021 Oct 11;12:754032
pubmed: 34707525
Gene. 2015 Aug 15;568(1):25-30
pubmed: 25958346
Invest Clin. 1992;33(1):13-31
pubmed: 1391074
Hum Mol Genet. 2009 Sep 1;18(17):3227-43
pubmed: 19483194
Nat Genet. 2019 Mar;51(3):431-444
pubmed: 30804558
Sci Rep. 2020 Dec 8;10(1):21423
pubmed: 33293633
Neurosci Lett. 2016 Nov 10;634:42-51
pubmed: 27717827
J Biochem. 2016 Dec;160(6):345-353
pubmed: 27387750
J Autism Dev Disord. 2000 Jun;30(3):205-23
pubmed: 11055457
Schizophr Res. 2004 Jun 1;68(2-3):283-97
pubmed: 15099610
Neuro Endocrinol Lett. 2015;36(5):465-80
pubmed: 26707048
J Biol Chem. 2008 Aug 8;283(32):22244-56
pubmed: 18544534
Br J Pharmacol. 2012 Mar;165(5):1543-55
pubmed: 21880034
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Dec 12;32(8):1905-12
pubmed: 18835577
Curr Psychiatry Rep. 2019 Jul 5;21(8):75
pubmed: 31278495
Mol Psychiatry. 2022 May;27(5):2380-2392
pubmed: 35296811
Schizophr Res. 2019 May;207:63-69
pubmed: 29699895
Biomolecules. 2022 Jun 29;12(7):
pubmed: 35883465
Transl Psychiatry. 2021 Oct 14;11(1):528
pubmed: 34650030
J Neurochem. 2015 Dec;135(5):849-58
pubmed: 26338675
Trends Mol Med. 2023 Dec;29(12):1014-1028
pubmed: 37770379
Biol Psychiatry. 2007 May 15;61(10):1200-3
pubmed: 17067558
PLoS One. 2014 Jul 08;9(7):e101652
pubmed: 25004141
PLoS One. 2016 Mar 17;11(3):e0150435
pubmed: 26986737
Neuropsychopharmacology. 2012 Jan;37(1):4-15
pubmed: 21956446
Lancet. 1995 Aug 26;346(8974):552-7
pubmed: 7544856
Front Mol Biosci. 2018 Nov 28;5:107
pubmed: 30547037
Int J Mol Sci. 2022 Mar 31;23(7):
pubmed: 35409220
Int J Mol Sci. 2020 Dec 23;22(1):
pubmed: 33374598
Arch Gen Psychiatry. 2005 Nov;62(11):1196-204
pubmed: 16275807
J Psychiatr Res. 2020 Apr;123:151-158
pubmed: 32065951
Sci Rep. 2017 Apr 10;7:46288
pubmed: 28393897
Biol Psychiatry. 2005 Mar 15;57(6):577-85
pubmed: 15780844
Psychiatry Clin Neurosci. 2019 May;73(5):204-215
pubmed: 30666759
Transl Psychiatry. 2022 Aug 1;12(1):305
pubmed: 35915065
Nat Microbiol. 2016 Jul 25;1(10):16125
pubmed: 27670111
Pharmacol Ther. 2020 Jan;205:107426
pubmed: 31629007
Nature. 2012 Jun 13;486(7402):261-5
pubmed: 22699620
Biomolecules. 2022 Jun 20;12(6):
pubmed: 35740983
NPJ Schizophr. 2017 Apr 6;3:16
pubmed: 28560262
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Jun;160(2):201-10
pubmed: 26740047
Schizophr Bull. 1987;13(2):261-76
pubmed: 3616518
Mol Cell Neurosci. 2011 Sep;48(1):20-8
pubmed: 21679769
Behav Brain Res. 2021 Jan 1;396:112886
pubmed: 32890599
Indian J Biochem Biophys. 2013 Oct;50(5):474-8
pubmed: 24772971
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2400-9
pubmed: 23729812
Biol Psychiatry. 2018 Sep 15;84(6):422-432
pubmed: 29397899
Biol Psychiatry. 2005 Jun 15;57(12):1493-503
pubmed: 15953485
Biol Psychiatry. 2002 Mar 15;51(6):493-7
pubmed: 11922885
Nucl Med Biol. 2005 Nov;32(8):793-7
pubmed: 16253803
Neurosci Bull. 2017 Apr;33(2):183-193
pubmed: 28213805
Prog Neurobiol. 1997 Jul;52(4):325-53
pubmed: 9247969
Brain Behav. 2019 Oct;9(10):e01383
pubmed: 31515952
Am J Psychiatry. 2017 Mar 1;174(3):216-229
pubmed: 27919182
Amino Acids. 2017 Jan;49(1):57-65
pubmed: 27686223
Schizophr Bull. 2012 Sep;38(5):920-6
pubmed: 22987850
Biochim Biophys Acta Proteins Proteom. 2020 Oct;1868(10):140471
pubmed: 32561430
Biol Psychiatry. 2000 Mar 1;47(5):450-62
pubmed: 10704956
Cells. 2023 Feb 10;12(4):
pubmed: 36831241
Am J Psychiatry. 2020 Dec 1;177(12):1119-1128
pubmed: 33256439
World Psychiatry. 2017 Oct;16(3):225-226
pubmed: 28941096
Schizophr Res. 2007 Sep;95(1-3):174-8
pubmed: 17630258
PLoS One. 2013 Apr 22;8(4):e62438
pubmed: 23630632
Schizophr Bull. 2012 Sep;38(5):958-66
pubmed: 22987851
J Neuroinflammation. 2014 Nov 19;11:189
pubmed: 25407263
Neurosci Lett. 2010 Jul 12;478(3):128-30
pubmed: 20452401
Schizophr Res. 2007 Feb;90(1-3):41-51
pubmed: 17156977
Schizophr Res. 2018 Jan;191:70-79
pubmed: 28318835
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Mar 2;82:187-194
pubmed: 29169997
Amino Acids. 2020 Apr;52(4):597-617
pubmed: 32185508
Curr Pharm Des. 2013;19(14):2499-511
pubmed: 23116391
Arch Gen Psychiatry. 2003 Jun;60(6):572-6
pubmed: 12796220
Neurochem Int. 2013 May;62(6):843-7
pubmed: 23439386
J Psychiatr Res. 1999 Nov-Dec;33(6):543-8
pubmed: 10628531
JAMA Psychiatry. 2013 Dec;70(12):1267-75
pubmed: 24089054
J Autism Dev Disord. 2012 May;42(5):827-36
pubmed: 21713591
Sci Adv. 2021 Mar 3;7(10):
pubmed: 33658193
J Biol Chem. 2002 Jul 26;277(30):27510-6
pubmed: 12021281
Front Psychiatry. 2021 Mar 29;12:514579
pubmed: 33854443
Neuroreport. 2016 Mar 2;27(4):272-6
pubmed: 26825346
J Psychiatr Res. 2013 Oct;47(10):1432-7
pubmed: 23835041
J Nephrol. 2023 Jul;36(6):1519-1547
pubmed: 37029882
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Dec 30;30(8):1472-7
pubmed: 16863675
Neurosci Biobehav Rev. 2022 May;136:104596
pubmed: 35248676
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):767-9
pubmed: 15939521
Neuropsychiatr Dis Treat. 2017 Apr 10;13:1057-1063
pubmed: 28435276
Psychiatr Genet. 2010 Apr;20(2):82-3
pubmed: 20145586
Front Psychiatry. 2018 Nov 06;9:559
pubmed: 30459655
PLoS One. 2017 May 3;12(5):e0175870
pubmed: 28467487
Front Mol Biosci. 2021 Jun 23;8:689719
pubmed: 34250021
JAMA Psychiatry. 2024 Mar 1;81(3):292-302
pubmed: 38294805
Neuropharmacology. 2012 Mar;62(3):1484-503
pubmed: 21295046
J Psychiatr Res. 2024 May 3;175:123-130
pubmed: 38728915
Nat Commun. 2019 Oct 15;10(1):4679
pubmed: 31616000
Neurochem Res. 2020 Jun;45(6):1344-1353
pubmed: 32189130
Schizophrenia (Heidelb). 2022 Feb 25;8(1):8
pubmed: 35217646
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Sep;30(9):2142-4
pubmed: 20855273
Neuropsychopharmacology. 2023 Jun;48(7):1052-1059
pubmed: 36928351
Clin Exp Nephrol. 2020 May;24(5):404-410
pubmed: 32112266
Data Brief. 2016 Feb 15;7:111-6
pubmed: 26933667
Sci Rep. 2019 Mar 25;9(1):5104
pubmed: 30911057
J Autism Dev Disord. 2003 Feb;33(1):93-7
pubmed: 12708584
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13409-14
pubmed: 10557334
Nature. 2022 Apr;604(7906):509-516
pubmed: 35396579